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Pharmaceutical Marketing And Entrepreneurship Pharmaceutical Companies in the Philippines  UNILAB History First name: United Drug Co. Inc Founders: Jose Y. Campos and Mariano K. Tan Year Established: Jan 15, 1945 1st location in the Philippines: Sto. Cristo Street,...

Pharmaceutical Marketing And Entrepreneurship Pharmaceutical Companies in the Philippines  UNILAB History First name: United Drug Co. Inc Founders: Jose Y. Campos and Mariano K. Tan Year Established: Jan 15, 1945 1st location in the Philippines: Sto. Cristo Street, Binondo, Manila.  UNILAB History 1954 The company expands into manufacturing as United Laboratories, Inc. (Unilab) and opens its first facility in V. Mapa Street, Manila. 1958 Unilab puts up another product division, Westmont. At the same time, Unilab begins export operations. Unilab transfers to Mayflower, Mandaluyong City. 1966 Unilab expands into animal healthcare with Univet Agricultural Products, known today as Univet Nutrition and Animal Health Company (UNAHCO).  UNILAB History 1983 Unilab puts up Pediatrica 2002 Unilab puts up Asian Antibiotics, Inc., a manufacturing plant in Sta. Rosa, Laguna. Unilab enters into unibranded generics with its RiteMED division. UNILAB Products  PASCUAL LABORATORIES History Founders: Isosceles and Leonora Pascual Year Established: 1946 1st location in the Philippines: Balut Island, Tondo Manila. PASCUAL LABORATORIES Products  TAISHO PHARMACEUTICALS Co. ltd History First Name: Taisho Seiyaku Founder: Seiji Ota Year Established: 1912 1st location in the Philippines: Makati City  TAISHO PHARMACEUTICALS Co. ltd History 1927 PABRON, best-known and longest-selling items. 1948 Changing the name to Taisho Pharmaceutical Co., Ltd. 1955 Registration of eagle mark as a trademark and beginning of its use in product advertising 1972 Taisho started its operations in the Philippines by importing LIPOVITAN TAISHO PHARMACEUTICALS Co. ltd Products  GETZ PHARMA History First Name: Getz Pharma Founder: Joseph Getz Year Established: 1995 1st location in the Philippines: Pasig, Metro Manila GETZ PHARMA Products  DIAMOND LABORATORIES History First Name: Diamond Laboratories, Inc Founder: Roberto V. Cabrera Jr. Year Established: 1984 Location in the Philippines: Quezon City Products  AMBICA INTERNATIONAL CORPORATION History First Name: Ambica International Corporation President: Kamal Abichandani Year Established: 2003 Location in the Philippines: Parañaque, Metro Manila Products Pharmaceutical Companies in the Philippines (Retailer)  Mercury Drug Store History Founders: Mariano Que Year Established: March 1, 1945 1st location in the Philippines: Bambang st. Manila Branches: over1200 Revenue : 132 billion (2017)  Southstar Drug History Founders: Tomas Dy-Makao Year Established: 1937 1st location in the Philippines: Naga city, Philippines Branches: 650 Revenue : 200-500 million  Watsons Drug History Founders: Tomas boswell Watson Year Established: 1841 1st location in the Philippines: Manila, Philippines Branches: 1000 Revenue : 30million dollars (2022)  The Generics Pharmacy History Founders: Benjamin I. Liuson Year Established: 2001 1st location in the Philippines: Banaue in Quezon City Branches: more than 2000  Top Pharmaceutical Companies In The World (Laboratory)  FOUNDERS ❖ Pfizer, Inc., named after Charles Pfizer, evolved from manufacturing chemicals to becoming a pharmaceutical giant, making groundbreaking contributions like the mass production of penicillin during World War II. Charles Pfizer Charles F. Erhart (1824–1906) (1821–1891)  HISTORY ❖ 1849: Charles Pfizer and Charles Erhart, two German ❖ 1941: Pfizer alone uses fermentation technology immigrants, founded Pfizer & Company in Brooklyn, among all companies pursuing mass production of New York. The company initially produced fine penicillin. chemicals, including an antiparasitic drug, santonin. ❖ 1950: Pfizer discovered and commercialized ❖ 1905: Emile Pfizer was the last member of the Terramycin (oxytetracycline), its first proprietary Pfizer/Erhart family to be actively involved with the antibiotic. company. ❖ 1967: Vibramycin (doxycycline hyclate), company’s ❖ 1906: Charles Pfizer died at the age of 82 while first once-a-day broad spectrum antibiotic. vacationing at his Newport, Rhode Island estate. ❖ 1980: Pfizer introduced Feldene (piroxicam), a ❖ 1919: Pfizer chemist James Currie and his assistant, breakthrough anti-inflammatory drug for arthritis. Jasper Kane, successfully pioneer the mass production of citric acid from sugar through mold fermentation. Year Established: 1849 Latest revenue: $45.9 Billion (as of 2024) Current main office: New York, United States Popular Pharmaceutical Products in the Philippines:  FOUNDERS A Swiss entrepreneur who founded F. Hoffmann-la Roche & co. In 1896 in Basel, Switzerland. At just 28 years old, he recognized the potential of industrial medicine production to combat diseases. Hoffmann was a pioneer in pharmaceutical manufacturing, focusing on standardized dosages and international marketing. Fritz Hoffmann-La Roche (1868-1920)  HISTORY ❖ 1896: Fritz Hoffmann-La Roche founded F. Hoffmann-La Roche & Co. in Basel, Switzerland. The company initially produced and sold vitamin preparations. ❖ 1934: Roche became the first company to mass-produce synthetic vitamin C, sold under the brand name Redoxon. ❖ 1940: Hilde Pfaltz becomes Roche’s first official company doctor, introducing standardized drug testing. ❖ 1997: Acquired Boehringer Mannheim, becoming a leader in in vitro diagnostics. ❖ 2009: Roche introduced Avastin (bevacizumab) and Herceptin (trastuzumab), two revolutionary cancer drugs that significantly advanced the treatment of breast and colorectal cancers. Year Established: 1896 Latest revenue: 58.7 billion Swiss (as of 2023) Current main office: Basel, Switzerland Popular Pharmaceutical Products:  FOUNDERS Robert W. Johnson James W. Johnson Edward M. Johnson February 20, 1845 – February 7, 1910 1856–1932 April 23, 1852 – March 20, 1934 Served as the first president of J&J The logo of J&J's early products Led the company’s sales and marketing resembled his signature division in the 19th century.  HISTORY ❖ 1886: Johnson & Johnson (J&J) is founded in New ❖ 1959: Acquisition of McNeil Laboratories, bringing Brunswick, New Jersey, by three brothers. The company initially focuses on surgical dressings and Tylenol (acetaminophen) into the J&J portfolio. sterile products. ❖ 1961: J&J acquires Janssen Pharmaceutica, entering ❖ 1888: J&J publishes the Modern Methods of Antiseptic the prescription pharmaceutical market. Wound Treatment manual, which revolutionizes medical care by promoting sterile techniques. ❖ 1963: Development of HALDOL® (haloperidol), a significant breakthrough in antipsychotic ❖ 1894: Introduction of Johnson’s Baby Powder, leading medications. to the development of a baby care product line. ❖ 1921: Introduction of BAND-AID® Brand Adhesive ❖ 1997: Introduction of REMICADE® (infliximab) for Bandages, invented by Earle Dickson, a J&J employee. autoimmune disorders, developed through Janssen. ❖ 1956: Johnson & Johnson opened its first operating ❖ 2016: Approval of DARZALEX® (daratumumab), a company in the Philippines. breakthrough in multiple myeloma treatment. Year Established: 1886 Latest revenue: $85.16 billion (as of 2023) Current main office: New Brunswick, New Jersey, USA. Popular Pharmaceutical Products:  FOUNDERS Is the chairman of the board and CEO of pharmaceutical company AbbVie. Originally an executive vice president at Abbott Laboratories, he was asked to lead AbbVie, its spinoff company, when it was launched in 2013. Richard A. Gonzalez  HISTORY ❖ 2013: AbbVie was officially launched as an independent biopharmaceutical company on January 2, 2013, following its ❖ 2018: U.S. regulatory approval of ORILISSA® (elagolix) spin-off from Abbott Laboratories. Began for endometriosis pain. trading on the New York Stock Exchange under the symbol “ABBV.” ❖ 2019: AbbVie announces the acquisition of Allergan, known for products like Botox®, to diversify its portfolio. ❖ 2015: The U.S. FDA approved AbbVie's treatment for Parkinson's disease and a ❖ 2020: Launch of RINVOQ® (upadacitinib) and SKYRIZI® therapy for moderate to severe (risankizumab) to address conditions like rheumatoid hidradenitis suppurativa. HUMIRA® arthritis and psoriasis, reducing dependence on received FDA approval for moderate-to- HUMIRA® severe hidradenitis suppurativa, a chronic inflammatory skin condition Year Established: 2013 Latest revenue: 55.53 billion (as of 2023) Current main office: North Chicago, Illinois Popular Pharmaceutical Products: FOUNDERS Friedrich Jacob Merck February 18 1621- 1678  HISTORY ❖ 1668: Friedrich Jacob Merck purchased a pharmacy ❖ 1944: Researchers at Merck isolated streptomycin, the in Darmstadt, Germany, called "Engel-Apotheke" first antibiotic effective against tuberculosis. (Angel Pharmacy). ❖ 1967: The company developed the first measles ❖ 1891: George Merck, a descendant of Friedrich vaccine, which later became part of the MMR vaccine Jacob Merck, emigrated to the United States and (measles, mumps, rubella). established Merck & Co. in New York City as the American branch of the German Merck company. ❖ 1980s: Merck launched ivermectin, a groundbreaking antiparasitic drug for both humans and animals. ❖ 1933: Merck developed the first Vitamin B1 ❖ 2006: The company launched Gardasil, the first vaccine (thiamine) synthesis, a breakthrough in treating for HPV (human papillomavirus) beriberi and other nutritional deficiencies. Year Established: 1668 Latest revenue: €22.2 billion (as of 2023) Current main office: Darmstadt, Germany. Popular Pharmaceutical Products in the Philippines:  FOUNDERS He is the CEO when Sanofi originally established in 1973 and under his leadership, the company rapidly expanded both organically and through strategic acquisitions. Chairman at Groupe Maori Chairman at Pierre Balmain Chairman-Orientation Committee at Bpifrance Participations Board of Directors at Provepharm He also served on the board at International Federation of Pharmaceutical Manufacturers Jean-François Dehecq Born: January 1, 1940  HISTORY ❖ 1973: Sanofi was founded as a subsidiary of Elf ❖ 2004: Sanofi-Synthélabo acquired Aventis, a Aquitaine, a French oil company. major pharmaceutical company created by the merger of Rhone-Poulenc Rorer and Hoechst ❖ 1980:Sanofi acquired Laboratoires Dausse, AG. gaining access to new pharmaceutical products and markets. ❖ 2014: Sanofi launched Toujeo, a long-acting insulin, as part of its commitment to diabetes ❖ 1982:The company acquired Synthélabo, a care. French pharmaceutical company specializing in over-the-counter (OTC) medications and ❖ 2018: Sanofi acquired Bioverativ, a company dermatology products. specializing in hemophilia and other blood disorders. Year Established: 1973 Latest revenue: $46.5 Billion (as of 2023) Current main office: 46 Avenue de la Grande-Armée Paris, France Popular Pharmaceutical Products in the Philippines:  HISTORY ❖ 1999: AstraZeneca was officially created ❖ 2008: The company introduced Crestor through the merger of Astra AB (Sweden) (rosuvastatin), a cholesterol-lowering statin that and Zeneca Group (UK). became one of its top-selling drugs. ❖ 2000: AstraZeneca launched Nexium ❖ 2014:The company launched Tagrisso (osimertinib), (esomeprazole), a blockbuster treatment for a breakthrough treatment for non-small-cell lung acid reflux and heartburn. cancer with specific genetic mutations. ❖ 2002: AstraZeneca’s cancer drug Iressa (gefitinib), used for non-small-cell lung cancer, was approved in Japan and later in other countries. ❖ 2007: AstraZeneca acquired MedImmune, a U.S.-based biotechnology company, Year Established: 1999 Latest revenue: $51.206 Billion as of 2024 Current main office: Cambridge Biomedical Campus, Cambridge, United Kingdom Popular Pharmaceutical Products in the Philippines: FOUNDERS Alexander Clavel (1805–1873)  HISTORY ❖ 1996: Novartis was formed through the merger of two major Swiss companies: Ciba- Geigy and Sandoz. ❖ 2015: Novartis acquired Actelion Pharmaceuticals, a leader in pulmonary arterial hypertension (PAH) ❖ 2000: Novartis acquired Chiron Corporation, treatments, significantly boosting its position in the an American biotechnology company, which specialty medicine market. helped enhance its portfolio in areas such as vaccines and biotechnology. ❖ 2020: Vasant Narasimhan became the CEO of Novartis, leading the company’s efforts to transform into a more ❖ 2010: Gleevec (Imatinib), developed by digitally-driven and innovative entity focused on Novartis, became one of the leading breakthrough therapies. treatments for chronic myeloid leukemia (CML) and was recognized for its groundbreaking approach to cancer treatment. Year Established: 1996 Latest revenue: $45.4 Billion as of 2024 Current main office: Basel, Switzerland Popular Pharmaceutical Products in the Philippines:  FOUNDERS Edward Robinson Squibb William McLaren Bristol John Ripley Myers ❖ Graduates from Philadelphia’s ❖ Graduated from Hamilton ❖ Graduated from Hamilton Jefferson Medical College. College College ❖ He spends a decade as a surgeon ❖ Businessman, Co-founder ❖ Physician, Co-founder of in the U.S. Navy. Medicine Chest. of Bristol-Myers, Bristol-Myers ❖ Established a quality-control lab Company's President until and partnered with his sons in the late 1920s 1892.  HISTORY ❖ 1847: Dr. Squibb established a laboratory in ❖ 1989: Bristol-Myers merged with Squibb Naval Hospital in Brooklyn, New York. Corporation, forming Bristol-Myers Squibb, becoming one of the world’s largest ❖ 1887: William McLaren Bristol and John Ripley pharmaceutical companies. Myers purchased the Clinton Pharmaceutical Company in New York, later renaming it ❖ 2001: BMS acquired DuPont Pharmaceuticals Bristol-Myers Company. Company, strengthening Bristol Myers Squibb’s HIV and cardiovascular businesses while also ❖ 1899: Clinton Pharmaceutical Industry was adding medical imaging. renamed “Bristol, Myers Company” then to “Bristol-Myers Corporation”; relocated first to ❖ 2019: BMS acquired Celgene Corporation, Syracuse, then Brooklyn, New York enhancing its oncology and immunology drug portfolio. ❖ 1943: Bristol-Myers acquired Cheplin Biological Laboratories and converted it to produce penicillin for World War II Allied forces. Year Established: 1 9 8 9 Latest revenue: $45 Billion as of Feb 2, 2024 Current main office: Lawrenceville, New Jersey. Popular pharmaceutical products: FOUNDERS Smith, Kline & French (Founded in the 1830s) An American pharmacist and businessman. He founded the pharmaceutical company john K. Smith & co., Which became a part of smith, Kline and French and GlaxoSmithKline.  FOUNDERS Beecham (founded in 1843) A british businessman who founded beechams, a large pharmaceutical business. He created the slogan for beecham's pills: "worth a guinea a box" , which is considered to be the world's first advertising slogan, helping the company become a global brand. Thomas Beecham 3 December 1820 – 6 April 1907  FOUNDERS Glaxo (Founded in 1873) Was a London-born new Zealand merchant, dairy manufacturer and exporter. A successful businessman, he returned to London in 1887 after 30 years in new Zealand. Joseph Nathan 1835 – 2 May 1912  FOUNDERS Burroughs Wellcome & Co. (Founded in 1880) ▪ An American ▪ Was an American pharmaceutical pharmaceutical entrepreneur. He entrepreneur who founded the founded pharmaceutical Burroughs company Burroughs wellcome & co. welcome & company with his colleague silas Burroughs in 1880, which is one of the four large companies to eventually merge to Silas Burroughs Henry Wellcome form GlaxoSmithKline. December 24, 1846 – February 6, 1895 21 August 1853 – 25 July 1936  HISTORY ❖ 1830s: John K. Smith founded a drug wholesaler in ❖ 1958: Beecham discovered ampicillin, a Philadelphia, USA, which later became Smith, Kline & breakthrough antibiotic French. ❖ 1972: Glaxo acquired Allen & Hanburys, entering ❖ 1843: Thomas Beecham founded Beecham in England, respiratory medicine. producing laxative pills. ❖ 1989: SmithKline Beckman merged with Beecham ❖ 1873: Joseph Nathan established a general trading company to form SmithKline Beecham. in New Zealand, which later became Glaxo. ❖ 1995: Glaxo merged with Burroughs Wellcome to ❖ 1880: Burroughs Wellcome & Co. was founded in London by form Glaxo Wellcome. Henry Wellcome and Silas Burroughs. ❖ 2000: Glaxo Wellcome merged with SmithKline ❖ 1935: Beecham Research Laboratories was established, Beecham to form GlaxoSmithKline (GSK), focusing on antibiotics. becoming one of the largest pharmaceutical companies globally. ❖ 1944: Smith, Kline & French launched the first effective tranquilizer, Thorazine.. Year Established: 2 0 0 0 Latest revenue: £30.3 billion (as of 2023) Current main office: London, United Kingdom Popular Pharmaceutical Products in the Philippines:  FOUNDERS Hans Christian Hagedorn August Krogh Danish physician and scientist Danish physiologist born on born on March 6, 1888, in November 15, 1874, in Grena, Copenhagen Denmark  HISTORY Novo nordisk history began a century ago with two Danish companies, Nordisk Insulin laboratorium and Novo Terapeutisk Laboratorium. Year Established: 1 9 8 9 Latest revenue: $33.724 Billion as of 2023 Current main office: Bagsbaerg, Denmark Popular pharmaceutical products: NovoRapid Ozempic Victoza Eli Lilly & Co  FOUNDERS Studied pharmacy as an apprentice in Lafayette, Indiana. A pharmaceutical chemist Graduated from the Philadelphia College of Pharmacy in 1854. Colonel Eli Lilly Served as a colonel in the Union Army July 8, 1838 - June 6, 1898 during the American Civil War. Baltimore, Maryland, USA  HISTORY ❖ 1876 - Founded by Colonel Eli Lilly in ❖ 1982 - Partnered with Genentech to produce Indianapolis, Indiana, to produce high-quality Humulin, the first insulin developed using and effective medicines. recombinant DNA technology. ❖ 1923 - Introduced Iletin, the first commercially ❖ 1987 - Released Prozac, a groundbreaking available insulin, revolutionizing diabetes antidepressant for treating depression and treatment. anxiety. ❖ 1955 - Lilly was the first company to ❖ 2004 - Launched Cialis, a treatment for erectile manufacture and distribute the Salk Polio dysfunction. Vaccine globally. ❖ 1958 - Lilly introduced Vancocin® (vancomycin hydrochloride, Lilly), an antibiotic forinfections associated with certain types of drug-resistant bacteria. Year Established: 1 8 7 6 Latest revenue: $28.5 billion (2023 estimate) Current main office: Indianapolis, Indiana, USA. Popular pharmaceutical products:  FOUNDERS William K. Bowes jr George B. Rathmann 1926 - December 28, 2016 December 25, 1927 - April 22, 2012 A venture capitalist, philanthropist, and co- An American chemist, biologist, pioneer in founder of U.S. Venture partners. biotechnology and corporate executive.  HISTORY ❖ April 8, 1980 - Applied as Applied Molecular Genetics,Inc. ❖ 1983- The Company officially changes its name to Amgen. ❖ Ju n e 1, 1989- the FDA approves EPOGEN® (epoetin alfa). EPOGEN® is named Product of the Year, by Fortune magazine. ❖ 1991: Approval of Neupogen (Filgrastim) Approved to help cancer patients undergoing chemotherapy fight infections. ❖ 1994 - Awarded the National Medal of Technology and Innovation for leadership in developing innovative therapeutics. ❖ 2002: Acquisition of Immunex Acquired Immunex Corporation for $16 billion, gaining the blockbuster drug Enbrel (Etanercept), used to treat autoimmune diseases Year Established: 1980 Latest revenue: $ 8.4 billion (2023 estimate) Current main office: Thousand Oaks, California, United States. Popular pharmaceutical products: FOUNDERS Chobei Takeda I Born: 1830, in Osaka, Japan  HISTORY ❖ 1781: Chobei Takeda I established a herbal medicine ❖ 1980: Takeda developed Leuprorin (leuprolide business in Doshomachi, Osaka, Japan, a hub for acetate), a treatment for prostate cancer, which pharmaceutical merchants. became one of its flagship drugs. ❖ 1871: Under the leadership of Chobei Takeda IV, the ❖ 1985: Takeda launched its blockbuster anti-ulcer drug, company began importing Western medicines, signaling Lansoprazole (Prevacid), which became a major its first steps toward modern pharmaceuticals. revenue driver in the 1990s. ❖ 1925: The company was formally incorporated as Takeda ❖ 1998: The company launched Actos (pioglitazone), a Pharmaceutical Industries, Ltd. diabetes treatment that became one of its most successful products globally. ❖ 1953: Takeda entered a licensing agreement with Eli Lilly and Company, giving it access to new antibiotics and ❖ 2019: Takeda completed its largest acquisition to date expanding its portfolio. by purchasing Shire, a biotech company specializing in rare diseases, for $62 billion. ❖ 1962: Takeda started operations in the United States by opening a subsidiary in New York, marking its first international expansion. Year Established: 1781 Latest revenue: ¥4,263.8 billion (2023 estimate) Current main office: Nihonbashi, Chuo, Tokyo , Japan. Popular pharmaceutical products: Entyvio (Vedolizumab) Ninlaro (Ixazomib) Vyvanse (Lisdexamfetamine) Qdenga Used for ulcerative colitis An oral treatment for A medication for ADHD and Crohn's disease A dengue vaccine. multiple myeloma. and binge eating disorder.  FOUNDERS Earned a Bachelor's degree in Humanities from Yale University. Received an M.D. (Doctor of Medicine) from the Johns Hopkins School of Medicine. Obtained an M.B.A. (Master of Business Administration) from Harvard Business School. Michael L. Riordan  HISTORY ❖ 1987: Gilead Sciences, Inc. was founded by ❖ 2004: The company launched Truvada, a Michael L. Riordan, a physician and entrepreneur, combination of emtricitabine and tenofovir, in Foster City, California. The company was revolutionizing HIV treatment by simplifying initially named Oligogen. therapy regimens. ❖ 1996: The company received its first FDA approval ❖ 2006: Gilead acquired Corus Pharma, for Vistide (cidofovir), an antiviral treatment for expanding its respiratory drug pipeline. cytomegalovirus (CMV) retinitis in AIDS patients. Atripla, the first once-daily single-tablet regimen for HIV treatment, was launched in ❖ 2001: Viread (tenofovir disoproxil fumarate) was collaboration with Bristol-Myers Squibb. approved for the treatment of HIV. This drug became the cornerstone of Gilead's HIV portfolio. ❖ 2018: Gilead launched Biktarvy, a once-daily, single-tablet regimen for HIV Year Established: 1987 Latest revenue: $27.1 billion (2023 estimate) Current main office: Foster City, California, United States Popular pharmaceutical products: Biktarvy Veklury (Remdesivir) Truvada HIV Treatment COVID-19 treatment  FOUNDERS Albert Boehringer (1861-1939) A German entrepreneur and chemist.  HISTORY ❖ 1885: Albert Boehringer purchases a small tartar factory in Ingelheim am Rhein. ❖ 1886:Albert Boehringer launches the production of tartaric acid for use in the food industry (e.g. in baking powder and fizzy lemonade). ❖ 1893: Following the death of his older brother Ernst (1860 – 1892), Albert Boehringer renames the company, with effect from 1 January, C. H. Boehringer Sohn in honour of his father, Christoph Heinrich Boehringer. ❖ 1912: C. H. Boehringer Sohn launches its first drug, Laudanon®, an analgesic based on six opium alkaloids. ❖ 1920: The company launches the cardiovascular drug Cadechol®, a camphor product rendered water soluble with bile acid. ❖ 1941: The respiratory product Aludrin® is launched, breaking new ground in the treatment of asthma. Year Established: 1885 Latest revenue: 27.7 billion (2023 estimate) Current main office: Ingelheim am Rhein, Germany Popular Pharmaceutical Products in the Philippines:  FOUNDERS Friedrich Bayer Johann Friedrich Weskott. June 6, 1825 - May 6, 1880 October 10, 1821 - October 4, 1876 Born in the barmen-heckinghausen district of the present-day city of wuppertal in 1825.  HISTORY ❖ 1863: Bayer was founded in Barmen (now part of ❖ 1978: Bayer introduced Cipro (ciprofloxacin), a Wuppertal), Germany, by Friedrich Bayer and groundbreaking antibiotic that became widely Johann Friedrich Weskott. Initially, the company used for bacterial infections. focused on manufacturing synthetic dyes. ❖ 2001: Bayer faced challenges related to Baycol ❖ 1897: Felix Hoffmann, a Bayer chemist, synthesized (cerivastatin), a cholesterol-lowering drug acetylsalicylic acid, later marketed as Aspirin (1899), withdrawn from the market due to safety concerns. one of the world's most widely used medications. ❖ 2016: Bayer announced the acquisition of ❖ 1904: Bayer introduced its iconic "Bayer Cross" logo, Monsanto, a leading agricultural company, for $66 which remains one of the most recognizable billion. pharmaceutical trademarks. ❖ 1912: The company moved its headquarters to Leverkusen, Germany, which remains its base of operations. Year Established: August 1, 1863 Latest revenue: $51.55 billion (2022) Current main office: Leverkusen, North Rhine-Westphalia, Germany. Popular Pharmaceutical Products in the Philippines:  FOUNDERS Haim Salomon Moshe Levin Yitschak Elstein  HISTORY ❖ 1901: Teva was founded in Jerusalem by Chaim ❖ 1976: Teva acquired Assia and Zori, two Salomon, Moshe Levin, and Yitschak Elstein as other Israeli pharmaceutical companies, a small wholesale distributor of imported strengthening its manufacturing and R&D drugs. capabilities. ❖ 1944: The company was renamed Teva (Hebrew ❖ 1980: Teva entered the U.S. market, which for "Nature") and focused on producing would become its largest and most penicillin and other essential medications for significant market for growth. the local market. ❖ 1996: Teva introduced a significant ❖ 1964: Teva began exporting drugs breakthrough with the launch of Copaxone® internationally, marking its expansion beyond (glatiramer acetate), a treatment for multiple Israel. sclerosis. Copaxone would go on to become one of Teva's top-selling drugs. Year Established: 1901 Latest revenue $16.772B (as of 2024) Current main office: Petah Tikva, Israel Popular Pharmaceutical Products VIATRIS Mylan N.V Upjohn Viatris  HISTORY ❖ 1961: Mylan Pharmaceuticals was founded in White Sulphur Springs, West Virginia, by Milan Puskar and Don Panoz as a small drug distribution company. ❖ 1886: Upjohn was established as an independent pharmaceutical company in Kalamazoo, Michigan. ❖ 1995: Pfizer acquired Upjohn, integrating it into its global operations. Upjohn focused on legacy branded medicines, including Lipitor, Lyrica, Viagra, and Celebrex. ❖ 2020: Viatris was officially formed through the merger of Mylan N.V., a leading generic and specialty pharmaceuticals company, and Upjohn, a legacy division of Pfizer that specialized in off-patent branded and generic medicines. Year Established: 2020 Latest revenue: $16.5 billion (as of 2023) Current main office: Canonsburg, Pennsylvania, USA. Popular Pharmaceutical Products:  HISTORY ❖ 1916: CSL (Commonwealth Serum ❖ 1994:CSL began expanding globally, acquiring Laboratories) was established in Bioplasma, a plasma fractionation facility, and Melbourne, Australia, by the Australian further strengthening its expertise in plasma- government. derived products. ❖ 1919: The first director, William Penfold, officially opened CSL's laboratory, ❖ 2000: Acquired ZLB Bioplasma, a Swiss marking the start of its operations. company, marking its entry into the global plasma products market. ❖ 1991: CSL was privatized by the Australian government, transforming ❖ 2009: Launched Privigen, an intravenous from a public entity into a company immunoglobulin (IVIG) therapy for patients listed on the Australian Stock Exchange with immune deficiencies and autoimmune (ASX). disorders. Year Established: 1961 Latest revenue: $10.6 billion (as of 2023) Current main office: Melbourne, Australia Popular Pharmaceutical Products: Beriglobin Berinert Albapure Respreeza