Clinical Therapeutics Pharmacology Spreadsheet - Week 5-10 Answers PDF

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+--------+--------+--------+--------+--------+--------+--------+--------+ | | | **Clas | **Drug | **Rece | **How | **Indi | **Othe | | | | s** | ** | ptor** | it | cation | r | | | | | | | works* | s** | inform | | | | | | | * | | ation* | | | | | | | | | * | +========+========+========+========+========+========+========+========+ | **WEEK | **Neur | Diuret | Mannit | | - ↓ | Cerebr | Risk: | | 5** | ology* | ic | ol | | wa | al | Mannit | | | * | | | | ter | oedema | ol | | | | | | | vo | | can | | | | | | | l, | ↑ | cross | | | | | | | ↓ | Ocular | blood | | | | | | | IC | pressu | vessel | | | | | | | P | re | s | | | | | | | by | | and | | | | | | | al | | into | | | | | | | tering | | inters | | | | | | | os | | titial | | | | | | | mosis. | | space | | | | | | | | | | | | | | | | - Fl | | Fluid | | | | | | | uid | | can | | | | | | | mo | | leak | | | | | | | ves | | back | | | | | | | ou | | into | | | | | | | t | | inters | | | | | | | of | | titial | | | | | | | sp | | space | | | | | | | aces | | | | | | | | | of | | ↑ | | | | | | | ce | | plasma | | | | | | | rebral | | osmola | | | | | | | ti | | rity | | | | | | | ssues | | à dec | | | | | | | in | | water, | | | | | | | to | | revers | | | | | | | in | | e | | | | | | | travas | | osmosi | | | | | | | cular | | s, | | | | | | | sp | | fluid | | | | | | | ace | | can go | | | | | | | | | back | | | | | | | | | into | | | | | | | | | brain | | | | | | | | | tissue | | | | | | | | | causin | | | | | | | | | g | | | | | | | | | cerebr | | | | | | | | | al | | | | | | | | | oedema | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Opioid | Naloxo | Mu | - Bl | Opioid | Very | | | | antago | ne | opioid | ocks | overdo | quick | | | | nist | | recept | th | se | onset | | | | | | or | e | | | | | | | | | ef | | Short | | | | | | | fects | | acting | | | | | | | of | | , | | | | | | | op | | need | | | | | | | ioids, | | repeat | | | | | | | by | | dosing | | | | | | | bl | | | | | | | | | ocking | | | | | | | | | op | | | | | | | | | ioid | | | | | | | | | re | | | | | | | | | ceptor | | | | | | | | | s | | | | | | | | | | | | | | | | | | - Pr | | | | | | | | | events | | | | | | | | | G | | | | | | | | | pr | | | | | | | | | otein | | | | | | | | | co | | | | | | | | | upling | | | | | | | | | sw | | | | | | | | | itch | | | | | | | | | (G | | | | | | | | | i/o | | | | | | | | | to | | | | | | | | | Gs | | | | | | | | | ) | | | | | | | | | of | | | | | | | | | th | | | | | | | | | e | | | | | | | | | mu | | | | | | | | | op | | | | | | | | | ioid | | | | | | | | | re | | | | | | | | | ceptor | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Sodium | GABA | - Bl | Preven | First- | | | | eizure | Valpro | agonis | ocks | ting | line | | | | | ate | t | vo | seizur | anti-s | | | | | | | ltage | es, | eizure | | | | | (Epili | | de | epilep | meds | | | | | m) | | pendan | sy, | | | | | | | | t | mania | | | | | | | | Na | | | | | | | | | ch | | | | | | | | | annels | | | | | | | | | | | | | | | | | | - ↑G | | | | | | | | | ABA | | | | | | | | | in | | | | | | | | | th | | | | | | | | | e | | | | | | | | | br | | | | | | | | | ain | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Phenob | GABA | - Re | Epilep | Rarely | | | | eizure | arbita | agonis | duces | sy, | used | | | | | l | t | th | sedati | | | | | | (barbi | | e | on | | | | | | tal) | | sp | | | | | | | | | read | | | | | | | | | of | | | | | | | | | se | | | | | | | | | izure | | | | | | | | | ac | | | | | | | | | tivity | | | | | | | | | fr | | | | | | | | | om | | | | | | | | | a | | | | | | | | | fo | | | | | | | | | cal | | | | | | | | | se | | | | | | | | | izure | | | | | | | | | | | | | | | | | | - Sl | | | | | | | | | ows | | | | | | | | | ac | | | | | | | | | tivity | | | | | | | | | of | | | | | | | | | th | | | | | | | | | e | | | | | | | | | br | | | | | | | | | ain | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Phenyt | Na | - Co | Tonic- | | | | | eizure | oin | channe | ntrol | clonic | | | | | | (Dilan | l | of | seizur | | | | | | tin) | modula | to | e | | | | | | | tor | nic-cl | manage | | | | | | | | onic | ment, | | | | | | | | se | preven | | | | | | | | izures | t | | | | | | | | | seizur | | | | | | | | - Re | es | | | | | | | | duces | during | | | | | | | | in | or | | | | | | | | flux | after | | | | | | | | of | neuros | | | | | | | | Na | urgery | | | | | | | | io | | | | | | | | | ns | | | | | | | | | th | | | | | | | | | rough | | | | | | | | | me | | | | | | | | | mbrane | | | | | | | | | s | | | | | | | | | st | | | | | | | | | abiliz | | | | | | | | | ing | | | | | | | | | th | | | | | | | | | e | | | | | | | | | th | | | | | | | | | reshol | | | | | | | | | d | | | | | | | | | ag | | | | | | | | | ainst | | | | | | | | | ex | | | | | | | | | citabi | | | | | | | | | lity | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Carbam | Na | - ↓ | Long | Adjunc | | | | eizure | azepin | channe | ne | term | t | | | | | e | l | rve | treatm | treatm | | | | | | modula | im | ent | ent | | | | | | tor | pulses | of | for | | | | | | | th | Seizur | schizo | | | | | | | at | es | phreni | | | | | | | ca | | a | | | | | | | use | Nerve | and | | | | | | | se | pain | bipola | | | | | | | izures | | r | | | | | | | an | | | | | | | | | d | | S/E | | | | | | | pa | | ↓Na, | | | | | | | in | | aplast | | | | | | | | | ic | | | | | | | | | anaemi | | | | | | | | | a | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Gabape | GABA | - Bl | Seizur | Potent | | | | eizure | ntin | neurot | ocks | es | ial | | | | | | ransmi | si | | for | | | | | | tter | gnals | Nerve | drug | | | | | | | fr | pain | abuse | | | | | | | om | | and | | | | | | | ne | | depend | | | | | | | rves | | ence. | | | | | | | to | | | | | | | | | th | | Can ↑ | | | | | | | e | | risk | | | | | | | br | | of | | | | | | | ain, | | suicid | | | | | | | me | | al | | | | | | | chanis | | though | | | | | | | m | | ts/beh | | | | | | | un | | aviour | | | | | | | known | | s | | | | | | | | | | | | | | | | | | CNS | | | | | | | | | depres | | | | | | | | | sant | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-s | Lamotr | Na | - in | Seizur | Does | | | | eizure | igine | channe | hibit | es | not | | | | | | l | vo | | treat | | | | | | modula | ltage | Nerve | acute | | | | | | tor | ga | pain | depres | | | | | | | ted | | sion, | | | | | | | so | Mania | can | | | | | | | dium | | cause | | | | | | | ch | bipola | worsen | | | | | | | annels | r | ing | | | | | | | an | | depres | | | | | | | d | | sion. | | | | | | | re | | | | | | | | | duce | | Abrupt | | | | | | | th | | cessat | | | | | | | e | | ion | | | | | | | re | | can | | | | | | | lease | | cause | | | | | | | of | | reboun | | | | | | | gl | | d | | | | | | | utamat | | seizur | | | | | | | e, | | es | | | | | | | an | | | | | | | | | ex | | | | | | | | | citato | | | | | | | | | ry | | | | | | | | | am | | | | | | | | | ino | | | | | | | | | ac | | | | | | | | | id | | | | | | | | | im | | | | | | | | | plicat | | | | | | | | | ed | | | | | | | | | in | | | | | | | | | th | | | | | | | | | e | | | | | | | | | pa | | | | | | | | | thophy | | | | | | | | | siolog | | | | | | | | | y | | | | | | | | | of | | | | | | | | | ep | | | | | | | | | ilepsy | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Dopami | Sineme | Dopami | - me | Parkin | Drug | | | | ne | t | ne | taboli | son's | intera | | | | precur | -- | agonis | c | | ctions | | | | sor | levodo | t | pr | | - MAO | | | | | pa | | ecurso | | inhibi | | | | | | | r | | tors, | | | | | | | of | | maxalo | | | | | | | do | | n, | | | | | | | pamine | | halope | | | | | | | , | | ridol, | | | | | | | cr | | stemet | | | | | | | osses | | il | | | | | | | bl | | | | | | | | | ood | | | | | | | | | br | | | | | | | | | ain | | | | | | | | | ba | | | | | | | | | rrier | | | | | | | | | an | | | | | | | | | d | | | | | | | | | co | | | | | | | | | nverts | | | | | | | | | to | | | | | | | | | do | | | | | | | | | pamine | | | | | | | | | in | | | | | | | | | th | | | | | | | | | e | | | | | | | | | br | | | | | | | | | ain | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Decarb | Carbid | | - in | Parkin | Drug | | | | oxylas | opa | | hibits | son's | intera | | | | e | | | pe | | ctions | | | | inhibi | | | ripher | | - MAO | | | | tor | | | al | | inhibi | | | | | | | co | | tors, | | | | | | | nversi | | maxalo | | | | | | | on | | n, | | | | | | | of | | halope | | | | | | | le | | ridol, | | | | | | | vodopa | | stemet | | | | | | | to | | il | | | | | | | do | | | | | | | | | pamine | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Sedati | Midazo | GABA A | - in | Seizur | CNS | | | | ve | lam | recept | tensif | e | depres | | | | | | or | y | | sant | | | | | | | th | Anaest | | | | | | | | e | hesia | | | | | | | | ph | | | | | | | | | ysiolo | | | | | | | | | gical | | | | | | | | | in | | | | | | | | | hibito | | | | | | | | | ry | | | | | | | | | me | | | | | | | | | chanis | | | | | | | | | ms | | | | | | | | | me | | | | | | | | | diated | | | | | | | | | by | | | | | | | | | GA | | | | | | | | | BA | | | | | | | | | | | | | | | | | | - sh | | | | | | | | | ort | | | | | | | | | ac | | | | | | | | | ting | | | | | | | | | ce | | | | | | | | | ntral | | | | | | | | | ne | | | | | | | | | rvous | | | | | | | | | sy | | | | | | | | | stem | | | | | | | | | de | | | | | | | | | pressa | | | | | | | | | nt  | | | | | | | | | | | | | | | | | | - he | | | | | | | | | lps | | | | | | | | | ↓ | | | | | | | | | th | | | | | | | | | e | | | | | | | | | ab | | | | | | | | | normal | | | | | | | | | an | | | | | | | | | d | | | | | | | | | ex | | | | | | | | | cessiv | | | | | | | | | e | | | | | | | | | ac | | | | | | | | | tivity | | | | | | | | | of | | | | | | | | | th | | | | | | | | | e | | | | | | | | | ne | | | | | | | | | rve | | | | | | | | | ce | | | | | | | | | lls | | | | | | | | | an | | | | | | | | | d | | | | | | | | | ca | | | | | | | | | lms | | | | | | | | | th | | | | | | | | | e | | | | | | | | | br | | | | | | | | | ain. | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | **WEEK | **GIT* | Histam | Raniti | H2 | - In | preven | | | 6** | * | ine | dine | recept | hibit | t | | | | | 2 | | or | H2 | gastri | | | | | blocke | Famoti | antago | re | c | | | | | rs | dine | nist | ceptor | ulcer, | | | | | | | | bl | stop | | | | | | | | ocks | produc | | | | | | | | pr | tion | | | | | | | | oducti | of | | | | | | | | on | gastri | | | | | | | | of | c | | | | | | | | ga | acids, | | | | | | | | stric | heartb | | | | | | | | ac | urn, | | | | | | | | id | dyspep | | | | | | | | | sia | | | | | | | | | (indig | | | | | | | | | estion | | | | | | | | | ), | | | | | | | | | hypera | | | | | | | | | cidity | | | | | | | | | , | | | | | | | | | gastri | | | | | | | | | c | | | | | | | | | and | | | | | | | | | duoden | | | | | | | | | al | | | | | | | | | ulcer | | | | | | | | | preven | | | | | | | | | tion | | | | | | | | | and | | | | | | | | | treatm | | | | | | | | | ent, | | | | | | | | | gastro | | | | | | | | | oesoph | | | | | | | | | ageal | | | | | | | | | reflux | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Anti-d | Lopera | Opioid | - Ac | Diarrh | Not | | | | iarrhe | mide | recept | tivate | oea | recomm | | | | al | | or | s | | ended | | | | | | agonis | op | | for | | | | | | t | ioid | | primar | | | | | | | re | | y | | | | | | | ceptor | | treatm | | | | | | | s | | ent | | | | | | | in | | of | | | | | | | gu | | infect | | | | | | | t | | ions | | | | | | | wa | | of GIT | | | | | | | ll | | | | | | | | | | | | | | | | | | - Re | | | | | | | | | duces | | | | | | | | | se | | | | | | | | | cretio | | | | | | | | | ns | | | | | | | | | an | | | | | | | | | d | | | | | | | | | in | | | | | | | | | hibits | | | | | | | | | mo | | | | | | | | | vement | | | | | | | | | in | | | | | | | | | gu | | | | | | | | | t | | | | | | | | | | | | | | | | | | - Al | | | | | | | | | lowing | | | | | | | | | re | | | | | | | | | absorp | | | | | | | | | tion | | | | | | | | | of | | | | | | | | | wa | | | | | | | | | ter | | | | | | | | | fr | | | | | | | | | om | | | | | | | | | st | | | | | | | | | ool | | | | | | | | | ba | | | | | | | | | ck | | | | | | | | | in | | | | | | | | | to | | | | | | | | | bo | | | | | | | | | dy | | | | | | | | | | | | | | | | | | - Re | | | | | | | | | duces | | | | | | | | | st | | | | | | | | | ool | | | | | | | | | fr | | | | | | | | | equenc | | | | | | | | | y | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Proton | Pantop | Protei | - Ca | GI | | | | | pump | razole | n | uses | lesion | | | | | inhibi | | pump | po | s, | | | | | tors | | inhibi | tent | gastro | | | | | | | tor | an | oesoph | | | | | | | | d | ageal | | | | | | | | lo | reflux | | | | | | | | ng-las | , | | | | | | | | ting | duoden | | | | | | | | su | al | | | | | | | | ppress | and | | | | | | | | ion | gastri | | | | | | | | of | c | | | | | | | | ga | ulcers | | | | | | | | stric | | | | | | | | | ac | | | | | | | | | id | | | | | | | | | se | | | | | | | | | cretio | | | | | | | | | ns | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Laxati | Lactul | | - Ma | Manage | Pathop | | | | ve | ose | | nage | ment | hysiol | | | | | | | en | of | ogy | | | | | | | cephal | hepati | of | | | | | | | opathy | c | enceph | | | | | | | à | enceph | alopat | | | | | | | pr | alopat | hy: | | | | | | | event | hy, | | | | | | | | am | stool | Ammoni | | | | | | | monia | soften | a | | | | | | | ab | er | (intes | | | | | | | sorpti | | tinal | | | | | | | on | | protei | | | | | | | in | | n | | | | | | | co | | digest | | | | | | | lon | | ion) | | | | | | | | | passes | | | | | | | - Re | | liver | | | | | | | absorb | | and | | | | | | | wa | | goes | | | | | | | ter | | to | | | | | | | ba | | brain | | | | | | | ck | | | | | | | | | in | | | | | | | | | to | | | | | | | | | st | | | | | | | | | ool | | | | | | | | | to | | | | | | | | | ma | | | | | | | | | ke | | | | | | | | | it | | | | | | | | | so | | | | | | | | | fter | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | **WEEK | **Endo | Insuli | Actrap | Insuli | - Lo | Hyperg | Short | | 8** | crine* | n | id | n | wers | lycaem | acting | | | * | | | recept | BG | ia | insuli | | | | | Novora | or | L | T1DM | n | | | | | pid | | by | and | | | | | | | | bi | T2DM | Peak | | | | | | | nding | | effect | | | | | | | in | | s | | | | | | | sulin | | 1.5-3. | | | | | | | re | | 5hrs | | | | | | | ceptor | | | | | | | | | s | | | | | | | | | to | | | | | | | | | ↑ | | | | | | | | | gl | | | | | | | | | ucose | | | | | | | | | up | | | | | | | | | take | | | | | | | | | an | | | | | | | | | d | | | | | | | | | in | | | | | | | | | hibit | | | | | | | | | he | | | | | | | | | patic | | | | | | | | | gl | | | | | | | | | ucose | | | | | | | | | ou | | | | | | | | | tput | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Insuli | Solost | Insuli | - re | Hyperg | Man-ma | | | | n | ar | n | gulati | lycaem | de | | | | | | recept | on | ia | insuli | | | | | Optisu | or | of | T1DM | n | | | | | lin | | gl | and | | | | | | | | ucose | T2DM | Long | | | | | | | me | | acting | | | | | | | taboli | | insuli | | | | | | | sm. | | n | | | | | | | ↓ | | | | | | | | | BG | | | | | | | | | L | | | | | | | | | by | | | | | | | | | st | | | | | | | | | imulat | | | | | | | | | ing | | | | | | | | | pe | | | | | | | | | ripher | | | | | | | | | al | | | | | | | | | gl | | | | | | | | | ucose | | | | | | | | | up | | | | | | | | | take, | | | | | | | | | es | | | | | | | | | p | | | | | | | | | by | | | | | | | | | sk | | | | | | | | | eletal | | | | | | | | | mu | | | | | | | | | scle | | | | | | | | | an | | | | | | | | | d | | | | | | | | | fa | | | | | | | | | t, | | | | | | | | | an | | | | | | | | | d | | | | | | | | | by | | | | | | | | | in | | | | | | | | | hibiti | | | | | | | | | ng | | | | | | | | | he | | | | | | | | | patic | | | | | | | | | gl | | | | | | | | | ucose | | | | | | | | | pr | | | | | | | | | oducti | | | | | | | | | on. | | | | | | | | | In | | | | | | | | | sulin | | | | | | | | | in | | | | | | | | | hibits | | | | | | | | | li | | | | | | | | | polysi | | | | | | | | | s | | | | | | | | | in | | | | | | | | | th | | | | | | | | | e | | | | | | | | | ad | | | | | | | | | ipocyt | | | | | | | | | e, | | | | | | | | | in | | | | | | | | | hibits | | | | | | | | | pr | | | | | | | | | oteoly | | | | | | | | | sis | | | | | | | | | an | | | | | | | | | d | | | | | | | | | en | | | | | | | | | hances | | | | | | | | | pr | | | | | | | | | otein | | | | | | | | | sy | | | | | | | | | nthesi | | | | | | | | | s. | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Biguan | Metfor | Antidi | - Re | T2DM | Only | | | | ide | min | abetic | duces | -- | oral | | | | | | agent | gl | first- | agent | | | | | | / | ucose | line | that | | | | | | anti-h | pr | treatm | can be | | | | | | ypergl | oducti | ent | used | | | | | | ycaemi | on | | in | | | | | | c | in | | combin | | | | | | drug | li | | ation | | | | | | | ver | | with | | | | | | | | | insuli | | | | | | | - ↑ | | n | | | | | | | in | | | | | | | | | sulin | | | | | | | | | re | | | | | | | | | ceptor | | | | | | | | | s | | | | | | | | | in | | | | | | | | | mu | | | | | | | | | scle | | | | | | | | | | | | | | | | | | - de | | | | | | | | | lay | | | | | | | | | ab | | | | | | | | | sorpti | | | | | | | | | on | | | | | | | | | of | | | | | | | | | gl | | | | | | | | | ucose | | | | | | | | | in | | | | | | | | | GI | | | | | | | | | T | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Sulfon | Glipiz | Pancre | - Ac | Adjunc | second | | | | ylurea | ide | atic | ts | t | -line | | | | s | | beta | on | to | diabet | | | | | | cells | pa | diet | ic | | | | | | | ncreat | and | contro | | | | | | | ic | exerci | l | | | | | | | be | se, | | | | | | | | ta | contro | | | | | | | | ce | l | | | | | | | | lls | hyperg | | | | | | | | to | lycaem | | | | | | | | in | ia | | | | | | | | c | | | | | | | | | se | | | | | | | | | cretio | | | | | | | | | n | | | | | | | | | of | | | | | | | | | in | | | | | | | | | sulin | | | | | | | | | an | | | | | | | | | d | | | | | | | | | in | | | | | | | | | c | | | | | | | | | th | | | | | | | | | e | | | | | | | | | re | | | | | | | | | sponse | | | | | | | | | of | | | | | | | | | in | | | | | | | | | sulin | | | | | | | | | at | | | | | | | | | th | | | | | | | | | e | | | | | | | | | ta | | | | | | | | | rget | | | | | | | | | ti | | | | | | | | | ssues | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | SGLT2 | Dapagl | GLT2 | - ↓ | Glycae | Precau | | | | | iflozi | inhibi | gl | mic | tion | | | | | ne | tor | ucose | contro | - | | | | | | | re | l | monito | | | | | | | absorp | T2DM | r | | | | | | | tion | | renal | | | | | | | in | | functi | | | | | | | ki | | on | | | | | | | dney | | | | | | | | | à | | | | | | | | | ↑ | | | | | | | | | ur | | | | | | | | | ine | | | | | | | | | ex | | | | | | | | | cretio | | | | | | | | | n | | | | | | | | | | | | | | | | | | - In | | | | | | | | | hibiti | | | | | | | | | ng | | | | | | | | | th | | | | | | | | | e | | | | | | | | | GL | | | | | | | | | T2 | | | | | | | | | re | | | | | | | | | ceptor | | | | | | | | | ca | | | | | | | | | uses | | | | | | | | | gl | | | | | | | | | ycosur | | | | | | | | | ia | | | | | | | | | an | | | | | | | | | d | | | | | | | | | os | | | | | | | | | motic | | | | | | | | | di | | | | | | | | | uresis | | | | | | | | | | | | | | | | | | - Re | | | | | | | | | duces | | | | | | | | | hy | | | | | | | | | pergly | | | | | | | | | caemia | | | | | | | | | , | | | | | | | | | we | | | | | | | | | ight | | | | | | | | | an | | | | | | | | | d | | | | | | | | | fl | | | | | | | | | uid | | | | | | | | | lo | | | | | | | | | ad | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | **WEEK | **Rena | Diuret | Frusem | NKCC | Frusem | Treatm | Loop | | 7** | l** | ics | ide | antago | ide | ent | diuret | | | | | | nist | | of | ics | | | | | Hydroc | | - Lo | HTN, | work | | | | | hlorot | | op | oedema | in | | | | | hiazid | | di | tous | loop | | | | | e | | uretic | condit | of | | | | | | | | ions | Henle, | | | | | Spiron | | - Pr | (CCF)) | intens | | | | | olacto | | events | , | e | | | | | ne | | Na | chroni | and | | | | | | | re | c | rapid | | | | | | | absorp | renal | diures | | | | | | | tion | failur | is | | | | | | | in | e | | | | | | | | lo | | counte | | | | | | | op | | ract | | | | | | | of | | the | | | | | | | He | | effect | | | | | | | nle | | s | | | | | | | | | of K | | | | | | | Hydroc | | loss | | | | | | | hlorot | | | | | | | | | hiazid | | | | | | | | | e | | | | | | | | | | | | | | | | | | - K | | | | | | | | | de | | | | | | | | | pletin | | | | | | | | | g | | | | | | | | | di | | | | | | | | | uretic | | | | | | | | | | | | | | | | | | - Ac | | | | | | | | | ts | | | | | | | | | in | | | | | | | | | DC | | | | | | | | | T | | | | | | | | | pr | | | | | | | | | eventi | | | | | | | | | ng | | | | | | | | | re | | | | | | | | | absorp | | | | | | | | | tion | | | | | | | | | of | | | | | | | | | Na | | | | | | | | | | | | | | | | | | Spiron | | | | | | | | | olacto | | | | | | | | | ne | | | | | | | | | | | | | | | | | | - K | | | | | | | | | sp | | | | | | | | | aring | | | | | | | | | di | | | | | | | | | uretic | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Hormon | Erythr | Growth | - St | Anemia | Given | | | | e | opoiet | factor | imulat | relate | 1-3/we | | | | | in | | es | d | ek | | | | | | | pr | to CRF | | | | | | | | oducti | requir | | | | | | | | on | ing | | | | | | | | RB | haemod | | | | | | | | C | ialysi | | | | | | | | | s, | | | | | | | | | cancer | | | | | | | | | treatm | | | | | | | | | ent | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Vitami | Vitami | | - In | Vitami | Can | | | | n | n | | crease | n | cause | | | | | D | | ab | D and | hyperc | | | | | | | sorpti | calciu | alcemi | | | | | | | on | m | a | | | | | | | of | defici | | | | | | | | ca | ency | | | | | | | | lcium, | | | | | | | | | Mg | | | | | | | | | S04, | | | | | | | | | ph | | | | | | | | | osphat | | | | | | | | | e | | | | | | | | | in | | | | | | | | | th | | | | | | | | | e | | | | | | | | | GI | | | | | | | | | T | | | | | | | | | | | | | | | | | | - Fa | | | | | | | | | t | | | | | | | | | so | | | | | | | | | luble | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Colloi | Albumi | | - Co | Fluid | Blood | | | | d | n | | ntains | resusc | produc | | | | | | | la | itatio | t, | | | | | | | rge | n, | derive | | | | | | | mo | shock, | d | | | | | | | lecule | rehydr | from | | | | | | | s | ation, | plasma | | | | | | | th | restor | | | | | | | | at | ation | Comes | | | | | | | do | of | in 4%, | | | | | | | n't | protei | 5%, | | | | | | | pa | n | 20% | | | | | | | ss | levels | | | | | | | | th | in the | Stays | | | | | | | rough | blood | in the | | | | | | | se | | intrav | | | | | | | miperm | | ascula | | | | | | | eable | | r | | | | | | | me | | space | | | | | | | mbrane | | longer | | | | | | | s | | than | | | | | | | | | crysta | | | | | | | - ↑ | | lloids | | | | | | | hy | | | | | | | | | drosta | | | | | | | | | tic | | | | | | | | | pr | | | | | | | | | essure | | | | | | | | | | | | | | | | | | - Ex | | | | | | | | | erts | | | | | | | | | an | | | | | | | | | os | | | | | | | | | motic | | | | | | | | | pu | | | | | | | | | ll | | | | | | | | | of | | | | | | | | | fl | | | | | | | | | uids | | | | | | | | | fr | | | | | | | | | om | | | | | | | | | in | | | | | | | | | tersti | | | | | | | | | tial | | | | | | | | | an | | | | | | | | | d | | | | | | | | | ex | | | | | | | | | tracel | | | | | | | | | lular | | | | | | | | | sp | | | | | | | | | aces | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | **Week | | Electr | Potass | | - As | Potass | Hyperk | | 9** | | olytes | ium | | sists | ium | alaemi | | | | | | | wi | defici | a | | | | | | | th | ency | lowers | | | | | | | mu | | the | | | | | | | scle | | cell-r | | | | | | | an | | esting | | | | | | | d | | potent | | | | | | | ne | | ial, | | | | | | | rve | | preven | | | | | | | fu | | ting | | | | | | | nction | | repola | | | | | | | , | | risati | | | | | | | ma | | on, | | | | | | | intena | | leadin | | | | | | | nce | | g | | | | | | | of | | to | | | | | | | no | | muscle | | | | | | | rmal | | paraly | | | | | | | ca | | sis | | | | | | | rdiac | | | | | | | | | el | | | | | | | | | ectrop | | | | | | | | | hysiol | | | | | | | | | ogy, | | | | | | | | | he | | | | | | | | | lps | | | | | | | | | mo | | | | | | | | | ve | | | | | | | | | nu | | | | | | | | | trient | | | | | | | | | s | | | | | | | | | in | | | | | | | | | to | | | | | | | | | ce | | | | | | | | | lls | | | | | | | | | an | | | | | | | | | d | | | | | | | | | wa | | | | | | | | | ste | | | | | | | | | pr | | | | | | | | | oducts | | | | | | | | | ou | | | | | | | | | t | | | | | | | | | of | | | | | | | | | th | | | | | | | | | e | | | | | | | | | ce | | | | | | | | | ll | | | +--------+--------+--------+--------+--------+--------+--------+--------+ | | | Crysta | NS | | - Sa | Fluid | | | | | lloid | 0.9% | | me | resusc | | | | | | | | os | itatio | | | | | | CSL | | molari | n, | | | | | | | | ty | shock, | | | | | | Dex5% | | as | rehydr | | | | | | | | bl | ation | | | | | | | | ood, | | | | | | | | | he | | | | | | | | | nce | | | | | | | | | no | | | | | | | | | fl | | | | | | | | | uid | | | | | | | | | sh | | | | | | | | | ifts | | | | | | | | | | | | | | | | | |