Pharmacokinetics MCQ PDF - 2nd Year Dental, ZU

# General Pharmacology ## 2nd Year Dental, ZU ### Pharmacokinetics #### Lec 1 and 2 ##### MCQ ###### On Pharmacokinetiks ###### Pharmacology ## General Pharmacology MCQ 1. What is the primary focus of pharmacokinetics? - a Mechanism of drug action - b Drug absorption, distribution, met...

# General Pharmacology ## 2nd Year Dental, ZU ### Pharmacokinetics #### Lec 1 and 2 ##### MCQ ###### On Pharmacokinetiks ###### Pharmacology ## General Pharmacology MCQ 1. What is the primary focus of pharmacokinetics? - a Mechanism of drug action - b Drug absorption, distribution, metabolism, and excretion - c Drug interactions with targets - d Therapeutic effects of drugs **Answer: b** 2. Which of the following processes describes the passage of a drug from the site of administration to systemic circulation? - a Metabolism - b Excretion - c Absorption - d Distribution **Answer: c** 3. What is the main mechanism for drug absorption across biological membranes? - a Active transport - b Endocytosis - c Passive diffusion - d Exocytosis **Answer: c** 4. Which of the following requires energy for drug movement across a membrane? - a Passive diffusion - b Facilitated diffusion - c Endocytosis - d Active transport **Answer: d** 5. Which route of drug administration has the fastest absorption rate? - a Oral - b Subcutaneous - c Intravenous - d Topical **Answer: c** 6. Which factor increases drug absorption? - a High ionization - b High lipid solubility - c Low pH for weak bases - d Low pH for weak acids **Answer: b** 7. What role does metabolism play in pharmacokinetics? - a Converts drugs into active forms - b Breaks down drugs into metabolites - c Distributes drugs throughout the body - d Eliminates drugs from the body **Answer: b** 8. Which factor related to patients affects drug absorption? - a Ionization - b Route of administration - c Drug solubility - d Pharmaceutical preparation **Answer: b** 9. What is the effect of calcium on the absorption of tetracyclines? - a Increases absorption - b Decreases absorption - c No effect - d Metabolizes the drug **Answer: b** 10. What is the term for the pH at which drug ionization is equal to its unionized form? - a Solubility constant - b Acid constant - c Dissociation constant (pka) - d Equilibrium constant **Answer: c** 11. Which of the following is a factor related to the drug affecting its absorption? - a Systemic circulation - b Vascularity - c Nature of the compound - d Pathological conditions **Answer: c** 12. Which type of transport involves the movement of substances from high to low concentration without energy? - a Active transport - b Facilitated diffusion - c Passive diffusion - d Endocytosis **Answer: c** 13. Which drug administration route is least suitable during shock? - a Intramuscular - b Oral - c Subcutaneous - d Inhalation **Answer: b** 14. What happens to weak acids in an alkaline solution? - a They become more lipid-soluble - b They become more water-soluble - c They remain unchanged - d They become more ionized **Answer: d** 15. Which absorption mechanism involves the drug binding to a cell membrane and being enveloped? - a Passive diffusion - b Active transport - c Endocytosis - d Facilitated diffusion **Answer: c** 16. Which factor decreases the absorption of local anesthetics when co-administered? - a Coadministration of adrenaline - b Coadministration of calcium - c Coadministration of vitamin B12 - d Coadministration of ferrous iron **Answer: a** 17. Which drug form is absorbed most efficiently? - a Suspension - b Tablet - c Solution - d Capsule **Answer: c** 18. What does high lipid solubility indicate about a drug's absorption? - a Decreased absorption - b No effect - c Increased absorption - d Unchanged metabolism **Answer: c** 19. What is the effect of a higher pka value on a weak acid? - a Stronger acid - b Weaker acid - c No change in acidity - d More ionized form **Answer: b** 20. Which process involves the movement of lipid-soluble drugs across cell membranes? - a Passive diffusion - b Active transport - c Endocytosis - d Facilitated diffusion **Answer: a** 21. What is bioavailability? - a The speed at which a drug is absorbed. - b The percentage of the drug that reaches systemic circulation. - c The method of drug administration. - d The time it takes for a drug to be metabolized. **Answer: b** 22. Which route of administration has 100% bioavailability? - a Oral - b Sublingual - c Intravenous - d Intramuscular **Answer: c** 23. What is the "first pass effect"? - a The drug's initial distribution in the body. - b The drug's first interaction with plasma proteins. - c The drug's metabolism before reaching systemic circulation. - d The drug's excretion through the kidneys. **Answer: c** 24. Which drug is affected by the hepatic first pass effect? - a Insulin - b Propranolol - c Estrogen - d Paracetamol **Answer: b** 25. What happens to drugs bound to plasma proteins? - a They are immediately active and diffusible. - b They are inactive and cannot be metabolized or excreted. - c They are transformed into toxic metabolites. - d They pass through the blood-brain barrier. **Answer: b** 26. Which factor affects drug distribution in the body? - a Plasma protein binding - b Route of administration - c Bioavailability - d First pass metabolism **Answer: a** 27. What is the main organ responsible for drug metabolism? - a Kidneys - b Lungs - c Liver - d Intestines **Answer: c** 28. What is the consequence of enzyme induction? - a Reduced drug interactions - b Failure of drug action - c Increased absorption rate - d Shortened half-life **Answer: b** 29. What is the primary site for drug excretion? - a Lungs - b Bile - c Kidneys - d Skin **Answer: c** 30. What does elimination half-life (t1/2) determine? - a The method of drug administration - b The dosage interval - c The route of absorption - d The bioavailability of the drug **Answer: b** 31. Which drug form is active and diffusible? - a Ionized - b Bound - c Free - d Inactive **Answer: c** 32. What is the importance of biotransformation? - a To increase drug lipophilicity - b To convert unionized drugs to water-soluble metabolites - c To enhance drug absorption - d To improve plasma protein binding **Answer: b** 33. Which barrier prevents certain drugs from passing into the brain? - a Placental barrier - b Blood-brain barrier - c Intestinal wall - d Hepatic barrier **Answer: b** 34. Which drug can cause teratogenicity if it crosses the placental barrier? - a Aspirin - b Penicillin - c Alcohol - d Insulin **Answer: c** 35. What is the consequence of enzyme inhibition on drug action? - a Reduced toxicity - b Increased drug interactions - c Shortened half-life - d Decreased pharmacological effects **Answer: b** 36. Where does drug absorption primarily occur? - a Liver - b Stomach - c Small intestine - d Kidneys **Answer: c** 37. Which drug is known for intestinal first pass effect? - a Nitroglycerin - b Propranolol - c Estrogens - d Insulin **Answer: c** 38. What happens to a prodrug during metabolism? - a It becomes inactive - b It becomes an active drug - c It becomes toxic - d It is excreted unchanged **Answer: b** 39. What effect does inflammation have on the blood-brain barrier? - a Decreases permeability - b Has no effect - c Increases permeability - d Destroys the barrier **Answer: c** 40. What is the consequence of drug binding to tissues? - a It becomes more toxic - b It is readily excreted - c It accumulates in specific organs - d It loses its pharmacological action **Answer: c**