Patho Exam #3 PDF

Patho Exam #3  Patho Exam 3~ Huntington's Disease Neurod...

Patho Exam #3  Patho Exam 3~ Huntington's Disease Neurodegenerative Ne Diseases , *inimation Clinical findings associated with Huntington’s and why do they occur? t aui Amyotrophic Lateral Sclerosis CABAisinhibitorstator Pharmacologic management choices for ALS: · dopamine everything will be opposite direct pathway ne Substantia Nigra pars compacta e amin Glu tam Dop Coretx ate Striatum (caudate,putamen) Glutamate Gaba mitochondrial damage promotes , neuronal survival GPi + Substantia - ONLY INTERVENTION W/PROVEN SURVIVAL pars reticulate BENEFIT !!! a Thalamus Gab · Edaravone -> exact MOA is unknown , but (motor nuclei) known to be a scavenger fantastic free-radical Indirect pathway - By destabilizing free radicals & damage to ROS, reduces oxidative neurons EXCELLENT adjunctive therapy w/ Substantia Nigra - ine Glutamate viluzole !!! Should NEVER be used pam pars compacta Do alone ! Coretx Striatum (caudate,putamen) Glutamate Gaba Parkinson's Disease GPe Gaba Subthalamic nuclei Dopamine Thalamus (motor nuclei) Gab a GPi + Substantia Pharmacologic management pars reticulate choices for Parkinson's - natrophe Clinical Phenotypes associated with Parkinson's: nat  Seizures Infectious causes of seizures Status Epilepticus & Management men Prescribed drugs that lower seizure threshold & promote seizure development 3 Alcohol Withdrawal.in l S regimens but selea IsoniazidecommonyinTantibiotic , · > decreased GABA - - Isoniazid-induced pyridoxine deficiency accumulation glutamate production, increased glutamate of neurons'seizure toxicity results in hyperexcitation aa apniinapain severenause , which is Clozapine (sother antipsychotics) + D2 antagonist and · utilized in the management of schizophrenia glutamatergic transmission, restis canincrease · - -CLASSICALLY causes arganulocytes (decreased WBC count which specifically affects granulocyte - based wBC's) and seizures !!