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Here is the content of the whiteboard in a structured markdown format: ## Immunoglobulins * **IgG**: crosses placenta & activates complement system * **IgA**: found in secretions, protects mucus membranes * **IgM**: associates with blood typing * **IgB**: found in B lymphocytes * **IgE**...

Here is the content of the whiteboard in a structured markdown format: ## Immunoglobulins * **IgG**: crosses placenta & activates complement system * **IgA**: found in secretions, protects mucus membranes * **IgM**: associates with blood typing * **IgB**: found in B lymphocytes * **IgE**: associates with allergies ## Hypersensitivity Reactions * **Type 1 = IgE mediated reaction (Allergic Reaction)** * 2nd exposure to allergen → IgE antibodies bind to mast cells & basophils → degranulation of mast cells & basophils releases histamines, leukotrines & prostaglandins → vasodilation & edema (Antibody attack) * **Type 2 = antibody-mediated response/autoimmune** * IgE/IgM binds to cell surfaces → cell damage via complement activation, phagocytosis, or cytotoxicity = autoimmune dx * **Type 3 = immune complex-mediated reaction (clogged filters)** * Insoluble antigen-antibody complex deposits in tissues → inflammation & tissue damage via complement activation & recruitment of inflammatory cells = system lupus erythematosus * **Type 4 = delayed hypersensitivity (slow T-cell response)** * "Think TB 2-day skin test" * 24-72 hours slowest reaction