NM703 Module 2 - Anemia and Immunology PDF
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This document presents information on anemia, discussing various aspects of this medical condition, including its definitions, diagnostic tests, and treatment options within the context of a module, possibly for a medical or healthcare curriculum.
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NM703: Module 2 – Anemia and Immunology Anemia © What is the level of hemoglobin that defines anemia in women? ¨ Below 12g/dL © What is the level of hemoglobin that defines anemia in pregnant women? ¨ Bellow 11g/Dl in the 1st and 3rd trimesters; less than 10.5g/dl in the 2nd trimester © List t...
NM703: Module 2 – Anemia and Immunology Anemia © What is the level of hemoglobin that defines anemia in women? ¨ Below 12g/dL © What is the level of hemoglobin that defines anemia in pregnant women? ¨ Bellow 11g/Dl in the 1st and 3rd trimesters; less than 10.5g/dl in the 2nd trimester © List the normal MCV and the MCV for normocytic anemia, microcytic anemia, and macrocytic anemia. ¨ Normal/Normocytic: 80-100 ¨ Microcytic: 100 © When do we need to order electrophoresis? ¨ To dx thalassemia or If they have any relatives with thalassemia © What are the iron indices? What do they mean? ¨ Serum iron test- this test measures the level of iron in the serum of the blood. ¨ Transferrin test- directly measures the level of transferrin in the blood. o Transferrin is the protein that transports iron throughout the body. o Under normal conditions, transferrin is typically one-third saturated with iron. This means that about 2/3 of its capacity is held in reserve. ¨ Total iron-binding capacity (TIBC)- measures the total amount of iron that can be bound by proteins in the blood. o Transferrin is the primary iron-binding protein and the TIBC is a good indirect measurement of transferrin availability. ¨ Unsaturated iron-binding capacity (UIBC)- this will indicate the portion of transferrin that has not yet been saturated with iron. o UIBC also reflects transferrin levels. ¨ Transferrin saturation- this reflects the percentage of transferrin that is saturated with iron. ¨ Serum ferritin- the amount of stored iron in the body. © Which indices are elevated or decreased for each condition? ¨ *see notes for the anemias* © How do we distinguish between vitamin B12 deficiency and folate deficiency? ¨ Serum methylmalonic acid and total homocysteine o Methylmalonic acid will be elevated in b12 deficiency © Describe the expected labs for iron deficiency anemia. ¨ Ferritin: low ¨ Reticulocyte: low ¨ TIBC: High ¨ MCV: