Neurobiochemistry Test CNS Module PC 2023 PDF

Biochemistry test for CNS module for PC-II, Nov, 2023 Name_________________________________ID:____________________Sign:___________ CHOOSE THE BEST ANSWER FROM THE GIVEN ALTERNATIVES 1. When GABA binds to its GABA-B receptor, it will do the following function A. Close potass...

Biochemistry test for CNS module for PC-II, Nov, 2023 Name_________________________________ID:____________________Sign:___________ CHOOSE THE BEST ANSWER FROM THE GIVEN ALTERNATIVES 1. When GABA binds to its GABA-B receptor, it will do the following function A. Close potassium channel C. open chloride channel B. Open sodium channel D. close calcium channel 2. Identify the WRONG statement about neurons A. Obtain its energy by anaerobic glycolysis B. Synthesize ketone bodies C. Use ATP for de/polarization and nerve impulse transmission D. Utilize ketone bodies as energy source in the feed state. 3. Wernicke korsakoff encephalopathy can be caused by deficiency of one of the following vitamins A. Vitamin-B1 B. vitamin-B3 C. vitamin-B6 D. Vitamin-B12 4. Our neuron does not prefer to use fatty acids as its energy source because of the following reasons, EXCEPT____ A. Delayed metabolic rate of fatty acids oxidation to provide ATP B. Neurons have insufficient enzymes for mitochondrial fatty acids beta-oxidation C. Low susceptibility of neurons to the oxidative damage D. Fatty acids can’t allow our survival when we are under hypoxic environment 5. The major inhibitory neurotransmitter in spinal cord and brain stem is______ A. Gamma-aminobutyric acid C. Glycine B. Glutamate D. Dopamine 6. You know that glucose is the chief source of energy for our brain. Thus, need continuous supply of glucose to brain cells. To do so one of the following glucose transporters is involved. A. GLUT-2 GLUT-3 C. GLUT-4 D. GLUT-5 7. The neurotransmitter that control inflammatory response is__________ A. Serotonin B. histamine C. Nitric oxide D. epinephrine 8. One of the following disorder of nervous system which impair psychomotor and caused by deficiency of UDP- GlcNAc phosphotransferase involved in carbohydrate metabolism is ________ A. Gauchers disease C. Mucolipidoses-II B. Oligosaccharidoses D. Sanfilippo syndrome 9. The over accumulation in one of following minerals is commonly known to decrease nerve impulse transmission/conductance A. Cupper B. calcium C. sodium D. potassium 10. All of the following amino acids are prevented by blood brain barrier from entering to the brain, EXCEPT________ A. Glutamate B. Alanine C. Aspartate D. Isoleucine 11. The abnormal metabolism of lipids in our brain is known to result in different neurologic diseases. One of the following diseases is caused by accumulation of excess sphingomyelin and so result in severe mental retardation. A. Tay saches disease C. Niemann-pick syndrome B. Gauchers disease D. Refsumes disease 12. All of the following neurotransmitters have both inhibitory and excitatory action depending on receptor type they bind, EXCEPT_____ A. norepinephrine B. Acetylcholine C. Dopamine D. Serotonin 13. One of the following vitamins is less likely to have (have no) significance in metabolism of nervous system A. Vitamin-B 6 Vitamin-C C. Vitamin-D D. vitamin-K 14. All of the following are amino acids that can directly act as neurotransmitter, EXCEPT_________ A. Glutamine B. aspartate C. Glutamate D. GABA 15. Identify the CORRECTLY matched between precursors and neurotransmitters (BONUS) A. 2-phosphoglycerate-glycine C. asparagine-nitric oxide B. serotonin-threonine D. oxaloacetate-aspartate Page 1 of 2  Biochemistry test for CNS module for PC-II, Nov, 2023 ANSWER SHEET Name________________________ID:_____________Sign:_______ 1. 9. 2. 10. 3. 11. 4. 12. 5. 13. 6. 14. 7. 15. 8. Page 2 of 2