Linezolid Antibiotic PDF
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Uploaded by FairDiction8624
University of Karachi
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Summary
This document discusses linezolid, an antibiotic, its mechanism of action, and resistance mechanisms. It also includes information on adverse effects, drug interactions, and dosing.
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Which is an essential component of bacterial translation process B/c of its unique MOA cross resistance b/w Linzolid and other class Of antibiotics is unlikely Many Streptococci, including penicillin-susceptible...
Which is an essential component of bacterial translation process B/c of its unique MOA cross resistance b/w Linzolid and other class Of antibiotics is unlikely Many Streptococci, including penicillin-susceptible & S.Pyrogene VRE.Fascecium - Gram positive rods e.g Corynebacteria & L. Monocytogene - Pneumonia caused by MSSA and MRSA Caused by MSSA and MRSA, S.Pyrogene, S.Agalactiae Enterococci & Staphylococci OR Bacteriocidal against most strain of Streptococci - Anemia - Neutropenia When drug administer longer than 2 weeks Lzd metabolize by oxidative metabolism Neither inducer nor inhibitor of CYTP450 enzyme b/c metabolize by oxidative metabolism Peak serum conc. 18mcg/ml Due to inhibition of Mitochondrial Protein Synthesis Mechanisms of Microbials Resistance Inactivation of drug by microbial enzy... (pepdidyl transferase) Decreased accumulation of drug by microbes Reduced affinity of target molecules for the drug
