Module A Past Paper 2011 PDF

# Ehtesham Shamsher Janvier 2011 Module A ## REMARKS IMPORTANTES - These questions have been transcribed after the exam. - They are incomplete for some. - There are almost a hundred questions. - Under no circumstances should they be forwarded by email from the faculty or posted on webshare. - Do n...

# Ehtesham Shamsher Janvier 2011 Module A ## REMARKS IMPORTANTES - These questions have been transcribed after the exam. - They are incomplete for some. - There are almost a hundred questions. - Under no circumstances should they be forwarded by email from the faculty or posted on webshare. - Do not talk to the professors about them. - Keep these questions for yourselves and do not distribute them to everyone. - Do not discuss these questions on the dokeos forums. - Several of these questions will most likely reappear in the next exams for module A. - Good luck! ## Science médicale de base ### Type A 1. eIF2 is reactivated by: a) Phosphorylation of the Threonine residue b) Exchange from GDP into GTP c) It's necessary to synthesize another one 2. Transcription factors: a) Cleave the DNA to allow transcription b) Are synthesized in the nucleus 3. Purified enzyme and substrate in vitro. Which reaction would make sense physiologically? a) Excess enzyme in the cell and secreted substrate 4. Correction on matrix: a) Ribosome that corrects the false triplets b) Exonuclease 5’-> 3’ c) Exonuclease 3’ -> 5’ d) Endonuclease 3’ -> 5’ e) Endonuclease 5’ -> 3’ 5. Which statement is correct: a) There is a greater amount of mRNA compared to other RNAs b) There are more mRNA molecules compared to other RNAs c) mRNAs have a well-defined secondary structure d) There are more genes that encode for other RNAs compared to mRNAs 6. Contributing to the evolution of the genome except: a) Exon shuffling b) Alternative splicing c) Recombinations d) Mutations 7. In case of phenylketonuria, it is necessary to give: a) A lot of phenylalanine b) No phenylalanine c) No tyrosine d) Little tyrosine 8. SDS in electrophoresis: a) Serves to break the covalent bonds of proteins b) Has 13 carbons c) Ends with a sulfate 9. PCR: Total number of DNA copies after 21 cycles if there are 800 initial copies: a) 800 \* 2^21 b) 800 \* 2^21 - 800 \* 2 \* 21 10. Using Array CGH in the following cases: a) Turner Syndrome b) Developmental delay and cardiac malformation c) Cystic fibrosis d) Recurrent miscarriages 11. In a general population, the risk of the disease is 40%; given lambda. Calculate the frequency of the disease in siblings: We must use the formula lambda = frequency siblings / frequency general population 12. Let's say there is an AR disease with a carrier frequency of 1/50. Calculate the incidence of the disease: a) 1/1000 b) 1/2000 c) 1/2500 d) 1/5000 e) 1/10000 13. Question about competitive inhibitor: - Does the Km increase? - Does the Vmax decrease? 14. The Krebs cycle balance counts in particular? - NADH GTP H2O oxaloacetate - NAD GDP acetyl COA citrate - succinate NADH FADH2 15. Regarding triglycerides: Choose the most correct statement a) They are made by saponification b) They are found in the cytoplasm c) They are mainly found in the cytoplasm of adipocytes 16. Question about the RB protein a) Its concentration remains constant throughout the cell cycle 17. The transmembrane domains at the level of integral proteins comprise which group: a) Alcohol b) Acid c) Basic d) Methyl e) Amine 18. The myotatic reflex is activated by: a) Ia sensory fibers b) Contraction of the neuromuscular spindle c) Excitatory interneuron d) Deactivation of the Golgi tendon apparatus 19. An osmotically active solution: a) Does not cross the membrane b) Is charged 20. Regarding the G protein, everything is correct except: a) There are small monomeric subunits. b) The subunits are anchored to lipids c) The Beta/gamma subunit has no signaling role d) Its activation makes DAG and IP3 e) Photons can activate it 21. Activation of phospholipase C beta induces: a) Intracellular ATP increase b) DAG and IP3 increase 22. It's an intra-articular ligament: a) Lateral collateral ligament of the knee b) Anterior talofibular ligament c) Anterior cruciate ligament of the knee d) Medial collateral ligament of the knee 23. Given a radio with 7 carpal bones, epiphysis not fully ossified. Give the patient's age: a) Newborn b) 2 years c) 11 years d) 40 years e) 100 years 24. Are organs in intermediate position (between extra and intra- serous): a) Duodenum b) Ascending-transverse colon 25. Where is bone marrow aspiration performed most often? a) Iliac crest b) Femur 26. Hematopoietic cells (cancer?) from a drainage type vena cava cause metastases in: a) Liver b) Lungs c) Heart d) Brain 27. Genetic counseling: a) Is mandatory before any human genetic analysis b) Should be performed with a pedigree c) Addresses the risks of recurrence and/or transmission d) Should be non-directive 28. The extraembryonic coelom is: a) Delineated by endometrium b) Delineated by trophoblast c) Obliterated by enlargement of the amniotic cavity 29. Morula compaction: a) Occurs after cavitation b) Requires blastomere migration c) Requires adhesion proteins 30. The 2nd division during female gamete formation takes place: a) After fertilization b) After ovulation 31. A breakdown of junctions causing the loss of proteins in the intestinal epithelium is due to: a) Tight junctions b) Desmosomes c) Tight junctions 32. A patient's urine has a high concentration of hydroxyproline. This suggests a significant degradation of: a) Collagen b) Elastin c) Proteoglycan 33. The cut is: a) Columnar epithelium b) B-stratified c) Stratified d) Simple 34. You can see in this cut: a) Cardiac muscle b) Smooth muscle c) Connective tissue Type K' 35. About bacteria: a) They are eukaryotic cells b) They have a rigid cell wall c) They have mitochondria 36. Regarding sequencing: a) Using nucleotides with a 3'OH 37. Give the polarity of the epithelial cell: a) Cytoskeleton b) Basal lamina c) Tight junctions d) Desmosomes 38. The inferior strait in women is delimited by: a) Pubic symphysis b) Promontory c) Terminal line 39. Intervertebral discs are: a) Synarthrosis b) Diarthrosis c) Syndesmosis d) Synchondrosis 40. Question about conditional specification (regulatory type) 41. Is present at the end of the second week: a) Primitive yolk sac 42. Teratogenic agents: 43. At the neuromuscular junction: a) Calcium is required b) Depolarization is necessary c) There is presynaptic vesicular transport of glutamate d) There are only ionotropic receptors # Physique générale (Certaines questions ressemblent aux TDs !) ## Type A 48. An object is thrown at an angle of 45° to the ground. Find the graph that shows the object's speed (see the white 2011 QCM => it's the same type!) 49. Thermodynamics: A graph where: a) Internal energy decreases b) Temperature increases c) It's an isothermal compression 50. Find the induced voltage when a coil enters a magnetic field. The vectors A and B are parallel. 51. A car takes a first turn (with a constant speed during this turn). Then, the same car takes a second turn where it accelerates. Find the correct diagram that gives the acceleration and angular acceleration vectors. 52. Give the direction of the torque, angular momentum and precession velocity vectors (like the example using the gyroscope). 53. Roger Federer hits a 60 [g] ball with a force of 1500 [N]. The ball is in contact with the racket for 2 [ms]. Calculate the ball's speed! 54. A 1 [g] positively charged particle is located between the plates of a capacitor at point A. At point A, its potential energy is ***[J]. What is the particle's speed at point B? # Type K' 55. An electromagnetic wave propagating in vacuum enters a dielectric with constant epsilon = 2. It can be stated that: a) Photon energy depends on the speed of the wave b) The wave frequency in the dielectric is the same as in vacuum c) The speed of the electromagnetic wave in the dielectric is lower than in vacuum d) The wavelength in the dielectric is shorter than that in vacuum 56. A person throws a wooden ball. The static and kinetic friction coefficients are given. Several statements concerning the friction force (like the exercises seen in class): 57. A question about dipoles, obviously! It's the same as in TDs 6. 58. The relative humidity is given at a temperature of 21 [°C]. At night, the temperature drops. a) Relative humidity increased b) There is more water in the form of vapor 59. An electron is in front of a capacitor plate (at point A), the plate being positively charged to 0 [V]. a) The force on the electron is directed following the X axis. b) The potential at point A is negative. c) The potential energy of the electron is positive at point A d) If we move the electron away from the plate, its potential energy increases. # Chimie organique (Bien revoir les TDs et les exemples donnés aux cours ! ) ## Type A 60. Given 5 aldoses represented by the Fischer projection. Say which one is achiral after a reduction by NaBH4. 61. Given a large molecule. Give its functional groups (lactone, alcohol, etc.). 62. Which one of these reactions is not possible? The reaction producing a cycle with a SP carbon! Indeed, a carbon cannot be SP if it is in a cycle. SP = angle between carbon atoms of 180°. However, in a cycle it's not possible. 63. Given a molecule (not in chair conformation) Say whether there is 1 or 2 substituents in axial or equatorial position. 64. Example of type TD 2 ex. 9 Attention, it wasn't the same molecule! 65. Given the D-galactosidase, draw its Haworth projection. 66. Given a large molecule. All carbons marked are in absolute R configuration except: 67. What is the transition state preceding the reaction intermediate: It’s the TD 5 exercise ex.2b. 68. Which molecule is the most basic: a) -COO' (the carboxyl group in its deprotonated form) b) -OH c) -NH2 d) Cycle-NH2 e) Amide 69. Number of stereoisomers of a molecule # Type K' 70. Which ones are mesomers: there were three tautomers and only one mesomer, I think. 71. Big molecule with two amide functions. What products can we get if we use a base, heat and water. It's an exercise that was done in class!!! 72. About the hybridization of carbons? # Chimie générale (Questions difficiles ! Beaucoup de données inutiles dans l'énoncé) ## Type A 73. Everything is correct about hemoglobin and myoglobin except: a) Number of hemes compared to myoglobin b) Efficiency of the protonated/deprotonated form c) Myoglobin's higher saturation for the same pressure 74. It's a homogeneous mixture: a) Bronze b) Sodium chloride c) Glucose d) Diamond e) Sand 75. Calculate delta(=d) G of the combustion of ethanol(=CH3CH2OH) (given dS, dH, R = 8.3, T = 298 [K], Gibbs formulas) # Type K' 76. Calculate the density of air in our lungs. Given: 80% N2 and 20% O2 in the air we breathe. 77. There is a 0.01 [M] HCl solution of 100 [mL], 100 [mL] of Cl- at 0.01 [M] is added. Calculate the pH of the new solution obtained. 78. KOH solution, NH4NO3 is added, calculate the pH. (Given volumes, molarities, pKa of H2O, KOH and HNO3) 79. Complexation reaction: (Ca2+) + [Prot] -> [Ca2+Prot] Given Beta 2, Ksp and the Ca2+ concentration for which the receptor is saturated. What Ca2+ concentration is needed for half-saturation of the receptor? 80. Regarding copper: a) It is a cold metal b) It is inert 81. Oxidation-reduction reactions are useful in medicine because: (choose the most accurate statement) a) The oxidant is reduced. b) Knowing the E value of a reaction makes it possible to predict its spontaneity. # Type K' 82. Regarding electrolysis a) The anode is negative 83. Regarding photosynthesis which produces glucose + O2? a) Endergonic reaction? b) Exergonic reaction? c) Water production? # PSS (Certaines questions identiques retombent chaque année...) ## Type A 84. Which one is a real disease? a) Chest pain b) Weight at birth below 2 standard deviations c) Myocardial infarction d) Cholesterol above 2 deciles (?) of the mean 85. The evolution of human behavior over the last 4000 years is due to? a) Improvement in jurisprudence b) Improvement in medicine c) Acquisition of a culture d) Language gene 86. A man goes to the doctor, because he has been in pain for 2 months, he thinks it's because of his new job. What factors are influenced by culture? a) Exam requested by the doctor b) Patient's representation of the disease c) Doctor's naming of the disease d) All of these answers are right 87. Human sciences are useful in all these cases except: a) Giving treatment b) Establishing a diagnosis c) Interpreting laboratory results 88. In Western Europe, the doctor-patient relationship **** (I don't remember the exact question ...), a) Influenced by the media b) Disappearance of medical symbolism 89. The apostolic function: It's sufficient to know its definition and that's it! 90. Regarding the definition of norm and disease: a) A disease is defined by a laboratory test result more than 1 standard deviation below the population mean b) A disease is easier to diagnose if its symptoms handicap the patient. c) A treatment to correct a risk factor is necessarily beneficial for patients d) When a screening test is positive, the person is certainly sick e) It's rare for the distribution of the value of a characteristic in the population to resemble a normal distribution 91. A question about ethics 92. According to WHO, health is defined as: a) Physical well-being b) Mental well-being c) All of these elements # Type K' 93. Regarding mirror neurons: a) Are only found in humans b) Are in the pre-motor cortex c) Are active when we see a gesture d) Allow for quick information integration 94. Regarding primordial, primary and secondary emotions: a) They are measurable 95. Regarding the doctor-patient relationship a) Patients' emotions and beliefs are measurable 96. Naturopaths: a) Are part of the popular sector