Module 5.docx

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- - - +-----------------------+-----------------------+-----------------------+ | | | - - | | | | | | | | | | | | | | | | - What are the | | | | indications for | | | | **Ezetimibe | | | | (Zetia)**? When | | | | would you use one | | | | or the other in | | | | addition to a | | | | statin? | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - - - | | | | | | | | - - How do you | | | | diagnose | | | | metabolic | | | | syndrome | | | | (syndrome X) | | | | -- a bunch of | | | | metabolic | | | | abdnormalitie | | | | s | | | | associated w/ | | | | high risk for | | | | AASCVD & DM | | | | II: | +-----------------------+-----------------------+-----------------------+ +-----------------------+-----------------------+-----------------------+ | | | - - - Nitroglyc | | | | erin | | | | (Organic | | | | Nitrate) -- | | | | acts directly | | | | on vascular | | | | smooth muscle | | | | (VSM) to | | | | promote | | | | vasodilation | | | | (mostly in | | | | veins), | | | | nitrate gets | | | | taken up by | | | | VSM & | | | | converted to | | | | Nitric oxide | | | | | | | | | | | | | | | | - Ranolazine | | | | (Ranexa) -- | | | | reduces Na & Ca | | | | in myocardial | | | | cells, used for | | | | 1^st^ line tx for | | | | chronic angina, | | | | often combined w/ | | | | nitrates, BBs, | | | | CCBs. Need EKG | | | | and renal | | | | function prior to | | | | starting due to | | | | the drug | | | | affecting the QT | | | | wave in the | | | | heart. This does | | | | not treat acute | | | | angina this is | | | | for chronic | | | | management. | | | | | | | | | | | | | | | | - - - - - - | | | | | | | | | | | | - - - | | | | | | | | - - | | | | | | | | | | | | | | | | - - What are | | | | presenting | | | | s/s of | | | | vitamin B12 | | | | deficiency? | | | | Anemia & | | | | injury to the | | | | nervous | | | | system | | | | (neurologic | | | | damage may | | | | never | | | | resolve) | | | | | | | | - In most | | | | cases, | | | | vitamin B12 | | | | deficiency is | | | | the result of | | | | impaired | | | | absorption | | | | resulting | | | | from regional | | | | enteritis, | | | | celiac | | | | disease, | | | | antibodies | | | | against | | | | intrinsic | | | | factor, and | | | | bariatric | | | | surgery and | | | | can cause a | | | | megaloblastic | | | | and | | | | macrocytic | | | | anemia | | | | | | | | - Causes | | | | demyelination | | | | of neurons | | | | causing | | | | paresthesias | | | | and reduced | | | | DTRs, later | | | | leading to | | | | loss of | | | | memory, mood | | | | changes, | | | | hallucination | | | | s, | | | | and psychosis | | | | | | | | - | +-----------------------+-----------------------+-----------------------+ +-----------------------+-----------------------+-----------------------+ | | | - | +-----------------------+-----------------------+-----------------------+