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What is a common cause of vitamin B12 deficiency?
What is a common cause of vitamin B12 deficiency?
What type of anemia can result from vitamin B12 deficiency?
What type of anemia can result from vitamin B12 deficiency?
What is a potential neurological consequence of vitamin B12 deficiency?
What is a potential neurological consequence of vitamin B12 deficiency?
What is a risk factor for developing vitamin B12 deficiency?
What is a risk factor for developing vitamin B12 deficiency?
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What is a characteristic of the anemia caused by vitamin B12 deficiency?
What is a characteristic of the anemia caused by vitamin B12 deficiency?
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What is a potential consequence of untreated vitamin B12 deficiency?
What is a potential consequence of untreated vitamin B12 deficiency?
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What is a mechanism by which vitamin B12 deficiency can occur?
What is a mechanism by which vitamin B12 deficiency can occur?
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What is a symptom of vitamin B12 deficiency?
What is a symptom of vitamin B12 deficiency?
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What is a complication of vitamin B12 deficiency?
What is a complication of vitamin B12 deficiency?
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What is a condition that can increase the risk of vitamin B12 deficiency?
What is a condition that can increase the risk of vitamin B12 deficiency?
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What is Ezetimibe (Zetia) primarily used for?
What is Ezetimibe (Zetia) primarily used for?
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What is the primary mechanism of action of Nitroglycerin?
What is the primary mechanism of action of Nitroglycerin?
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What is Metabolic Syndrome (Syndrome X) associated with?
What is Metabolic Syndrome (Syndrome X) associated with?
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What is the primary indication for Ranolazine (Ranexa)?
What is the primary indication for Ranolazine (Ranexa)?
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What is the effect of Nitroglycerin on veins?
What is the effect of Nitroglycerin on veins?
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How is Nitric oxide produced in vascular smooth muscle?
How is Nitric oxide produced in vascular smooth muscle?
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What is a common combination therapy for chronic angina?
What is a common combination therapy for chronic angina?
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What is the primary action of Ranolazine (Ranexa) in myocardial cells?
What is the primary action of Ranolazine (Ranexa) in myocardial cells?
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What is the main difference between Ezetimibe and statins?
What is the main difference between Ezetimibe and statins?
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What is the primary goal of using Ezetimibe (Zetia) in addition to a statin?
What is the primary goal of using Ezetimibe (Zetia) in addition to a statin?
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What is the main purpose of the medication mentioned in the passage?
What is the main purpose of the medication mentioned in the passage?
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What is a potential side effect of the medication mentioned in the passage?
What is a potential side effect of the medication mentioned in the passage?
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What is not a use of the medication mentioned in the passage?
What is not a use of the medication mentioned in the passage?
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Study Notes
Indications for Ezetimibe (Zetia)
- Used in addition to a statin to lower cholesterol levels
- Indications for use are not specified, but it is used to reduce cholesterol levels
Diagnosis of Metabolic Syndrome (Syndrome X)
- A group of metabolic abnormalities associated with high risk for AASCVD and DM II
- Characteristics include:
- Abdominal obesity
- Insulin resistance
- Hypertension
- Dyslipidemia
- Diagnosis involves identifying at least three of these characteristics
Nitroglycerin
- Acts directly on vascular smooth muscle to promote vasodilation (mostly in veins)
- Nitrate gets taken up by VSM and converted to nitric oxide
Ranolazine (Ranexa)
- Reduces Na and Ca in myocardial cells
- Used for 1st line treatment of chronic angina
- Often combined with nitrates, BBs, CCBs
- Requires EKG and renal function monitoring prior to starting due to the drug affecting the QT wave
- Does not treat acute angina, but rather chronic management
Vitamin B12 Deficiency
- Presenting symptoms include:
- Anemia
- Injury to the nervous system (neurologic damage may never resolve)
- In most cases, vitamin B12 deficiency is the result of impaired absorption
- Causes include:
- Regional enteritis
- Celiac disease
- Antibodies against intrinsic factor
- Bariatric surgery
- Can cause a megaloblastic and macrocytic anemia
- Causes demyelination of neurons, leading to paresthesias and reduced DTRs, later leading to loss of memory, mood changes, hallucinations, and psychosis
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