Methylketone bis Guanidin PDF

° H O I O I O + 3 I2 OH-...

° H O I O I O + 3 I2 OH- + - H I I H O R - 3 HI R R H I I R CH3 R R R R OH OH OH O O Cl CH3 Cl H3C (OH-) Cl CH3 Cl H + CH3 Cl OH Cl O – 1 R R O R R H3C O R CN NO 2 R H3C N 2 R O O O O O O  4- 3- (NC) 5Fe CH3 + H+ (NC) 5Fe CH3 N N – O O - H+ OH O rot violett  – – O O – – O N+ O N+ O 2N O O 1 – R CH 2 N+ Ox. N+ C R + NO 2 – O – O O H 2 1 C R R CH 2 C R 1 R C O O O O R H 3C HO O O N CH3 H3C H 3C O H H H CH3 O OH H N H N CH3 CH3 O O Hydromorphon Oxycodon Methadon F N O X OH X = Cl: Haloperidol X = Br: Bromperidol O O CH3 CH3 CH3 H H3C HO H3C O O O O OH H HO O HO O H OH Digitoxin  NO 2 H (OH-) H O H3C CH3 N O O N H O  – – N N + N N O OH - O (OH ) O O OH R R R H OH N N H N N OH O H5C6 C6H5 CH3 N N O OH + N N+ N N 2 Cl- CH3 H N N H5C6 H3CO OCH 3 C6H5 H H O Tetrazolblau Prednison  O O H3C H3C H H O H O H , HCl , 2 H2O H N H N CH3 CH3 HO HO Codein Codeinhydrochlorid-Dihydrat O O H3C H3C H H O H , H3PO4 , ½ H2O O H , H3PO4 , 1½ H2O H N H N CH3 CH3 HO HO Codeinphosphat-Hemihydrat Codeinphosphat-Sesquihydrat  H + + + + R NH2 N O R N N R N N O - H2O H H C H2 H2 N - H+ R CH2 C NH2 NaNO2 / HCl C N+ H2 R C R C C + - N2 R CH2 H2 H2 H2 + H2O C OH + R C -H H2 NH2 Amantadin  R NaNO2 / HCl R + N NH2 N N N NH2 N-(1-Naphthyl)ethylendiamin- 2-Naphthol NH dihydrochlorid ( -Naphthol) OH · 2 HCl (Bratton-Marshall-Reagenz)  O O O O O O H2N H2N Cl S S S S COOH N NH O O O N CH3 Cl N Cl N H H H Diazoxid Hydrochlorothiazid Furosemid NP: Essigsäure C6H5 H O H O N N CH3 N N N C6H5 O 2N N H9C4 N + H Cl O - O Phenylbutazon Benzidin-Umlagerung! Nitrazepam Chlordiazepoxid NP: Methylamin, Glycin-N-oxid Arzneistoff Verunreinigung CH3 H CH3 N N CH3 NH2 O CH3 CH3 CH3 Lidocain NO 2 OH O NO 2 N H H2N Cl Cl Niclosamid Cl N CH3 CH3 CH3 NH2 N H2N O COOH Methaqualon  – H CH3 2 2 N H CH3 R Zn / HOAc R 2 O CH3 R N N N N NH2 1 1 - H2O N N CH3 R O R 1 R 1 1 R HNO2 O R N N N 2 2 R R  1 R 2 N R N C O H 1 N C R + N R 2 O H H R N + + - S C S 2 R NH2 C S R NH3 S – – – – – – ≡ H2O (H+), + R-NH2, H5C2O OC 2H5 O O N O - 2 C2H5OH - H2O R H CH3 N (H+) O CH3 + H+ N CH3 N CH3 R R N+ N - H2O HO CH3 CH3  H R O O O N R + NH2 O R H H - H2O N SO 3Na SO 3Na - NaHSO3 HN SO 3Na H R O OH HO N NH2 H2O - RCHO SO 3Na SO 3Na O O O H O O O + R NH2 - NaHSO3 SO 3Na N N R H R O O O O 1 + R NH 2 R - NaHSO3 SO 3Na 1 N 2 R R – – O H C6H11 H O O + H2N-OH N C6H11 R N C6H11 R R + N C N O C N OH + O C OH H11C6 N C6H11 N C6H11 H H O O H R N C6H11 R O C N C6H11 N C6H11 O C N C6H11 H  ³ ² O O (Ni2+) R R + H2N OH N OH OH - H2O H – ≡ –  Cl COOH O N CH3 O O CH3 N S N H3C H H CH3 O Benzylpenicillin HOOC Indometacin OH H + H + C - H2O O O – O H + C O R NH + R NH2 - H+ O O – – – – – ³ 1 R H x3 N Fe3+ O O O O H2N-OH (HCl) O 2 OH 3+ R 1 O Fe NH R 1 O - R2OH R N H 1 R O O N 1 H R –  O O OH O CH3 O O H2N CH3 Benzocain Acetylsalicylsäure ³ –  I HO COOH COOH I O HO H CH3 NH2 NH2 H2N HO HO I HO COOH I Levodopa Methyldopa Levothyroxin  R O O O O COOH OH - H2O H2N N R O N OH + H2O - H2O - CO2 R O O O O O OH H O O O O O H2O NH2 - RCHO - H2O - H+ N N O O OH – OH O O N+ O Mit Prolin: – O O O ² R O H2N Cu NH2 O R O  – – R H2N COOH O 2N F + COOH - HF O 2N NH R NO 2 NO 2 HO H R O H2N H N N O 2N O 2N + COOH - HCl O 2N O O R Cl R O HO O R O - R N N + O 2N H N - H2O O - H+ O O O - O COOH COOH HO HO H CH3 H2N H2N HO HO Levodopa Methyldopa  – H2N HN H2O O O Ox. COOH COOH COOH H R R - NH3 R - CO2 R ²  – – – – – ³ R O O x3 N OH OH Fe3+ O HN O + Cl - HCl N O Fe 3+ O N R R R O O N R OH NO 2 O H Cl N H Cl OH Chloramphenicol  O CH3 N N O O N H2N S N H2N S N H H O O Sulfamethoxazol Sulfadiazin O O O O H2N H2N S S S COOH NH O O O Cl N Cl N H H Furosemid Hydrochlorothiazid O H H N N S O O O Cl N H Glibenclamid O CH3  ² ² ² O O OH S O (H+) R NH + R S NH2 - H2O O O O  O H2N S NH2 O Sulfanilamid Br O O H 2 Br2 H H2N S N H2N S N O R - 2 HBr O R Br – N N O N N H2N S N H H2N O  + H2N + H+ H2N H2N H2N + NH NH2 NH2 NH2 + H2N -H H2N H2N+ H2N  – – H2N N H2N OCl- Cl NH OH- Cl N C NH2 NH2 NH2 - OH- N R N R N - H2O R N - Cl- R OH O O H2N H2O NH OCl- OH- R N O N - H2O N H NH N R R – N O N O H H Br NH NH - NH N OBr R R R R N N N - OH - N N N - HBr H H H H H H N N N N R R OBr- R R N N N N N N H H H H  CH3 OH HN NH2 OH HN NH NH H2N N O CH3 O OH N H2N N N HO O OH N NH2 H H CH3 O CHO Guanethidin Metformin N OH CH3 OH H2N NH2 Streptomycin Cl NH2 NH2 H H N N N CH3 N N N N N N H NH2 NH2 CH3 NH2 NH2 Cl Cl Chlorhexidin Proguanil