mendellian 2.docx
Transcript
Chi-squared test is used to predict expected numbers based on hypothesis. Comparison to critical value is made to either accept or reject the hypothesis. Pedigree- presentation of family information First step in studying inheritance. Depicts phenotypes. Predicts family information. Dominant trait=...
Chi-squared test is used to predict expected numbers based on hypothesis. Comparison to critical value is made to either accept or reject the hypothesis. Pedigree- presentation of family information First step in studying inheritance. Depicts phenotypes. Predicts family information. Dominant trait= in every generation, at least one individual will be effected. Recessive trait= can effect individuals when neither parent is affected. Inconclusive pedigrees= arise due to small family, could be autosomal dominant because it effects both males and females but also could be autosomal recessive individuals are carriers. Autosomal dominant= polydactyly and Huntington disease Autosomal recessive= cystic fibrosis and sickle cell anaemia. Sickle cell anaemia Point mutation in alpha chain from glutamate to valine. Can be sex-linked diseased too. X-linked recessive disease= higher chance in males than females X-linked dominant disease Y-linked disease= only effect males.
