Medicinal Chemistry Chapter 4: Receptors and Drug Targets

Chapter 4. * I % Discuss function of receptors. Discuss types of substrates that bind receptors, and the interactions involved. Receptors proteins which are...

Chapter 4. * I % Discuss function of receptors. Discuss types of substrates that bind receptors, and the interactions involved. Receptors proteins which are make up the drug targets most important in medicine Receptors are used to carry messages across the gap"Communicationoccurs primarily of is Receptors receive messages coming from other cells. Neurotransmitters are one type of substrate that binds receptors on a target cell Hormones. are also another kind of receptor that binds to receptors on target cells throughout the body. Hydrogen bonding , interactions and ionic bonding , covalent bonds hydrophobic occur 2 - Describe important characteristics and functions of the receptor superfamilies and be able to categorize receptors. Ion channel receptors, G-Protein Coupled Receptors, Kinase Receptors, Intracellular Receptors ⑤ ion channel receptors: these receptors respond milliseconds channel receptors are & in Ion. made up of proteins that transverse the cell membrane and provide a hydrophilic tunnel. channels for specific Fon are specific ions (Nat , Ca2+, Cl- , K+ ) The · protein subunits that. make up an ion channel are glycoproteins xg-protein Coupled receptors: some of the most important drug targets in medicinal chemistry binds. Receptor messenger leading a to an induced bound that fit They. are membrane proteins activate G-proteins. It is single protein with a 7 transmembrane sections. * kinase receptors : receptors that activate C-protein - that do not enzymes require a. Bifunctional receptor/enzyme-Activated by hormones. * Intracellular receptors : receptors that resideinsideac Single as prote site g