MDB 203 - Introduction to General Metabolism Past Paper PDF

# DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### IKEJA-LAGOS #### B.Sc. (Hons.) PHYSIOLOGY 200E HARMA TAN (1ST) SEMESTER 2014/2015 #### SESSION EXAMINATIONS ##### MDB 203: INTRODUCTION TO GENERAL METABOLISM. * **TIME ALLOWED:** 2 HOURS * **DATE:** WEDNESDAY, 2...

# DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### IKEJA-LAGOS #### B.Sc. (Hons.) PHYSIOLOGY 200E HARMA TAN (1ST) SEMESTER 2014/2015 #### SESSION EXAMINATIONS ##### MDB 203: INTRODUCTION TO GENERAL METABOLISM. * **TIME ALLOWED:** 2 HOURS * **DATE:** WEDNESDAY, 29TH JULY, 2015 * **INSTRUCTIONS:** ANSWER ANY THREE QUESTIONS. ALL QUESTIONS CARRY EQUAL MARKS 1. a. Briefly describe using appropriate examples the interphase between catabolism and anabolism in intermediary metabolism. b. What is the significance of ATP in intermediary metabolism? 2. Write concisely on any TWO of the following: a. Mechanism of Enzyme action. b. Laws of Thermodynamics c. Feed back Inhibition 3. a. What are Enzymes b. Briefly explain the attributes of enzymes and the factors affecting their reactions? 4. a. What do you understand by Bioenergetics? b. Briefly describe the following Types of Energy: potential, kinetic and chemical energy. 5. a. Briefly describe Metabolic Pathways using specific examples. b. Briefly differentiate between Cofactors and Active sites of Enzymes # DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### KEJA-LAGOS #### B.SC PHYSIOLOGY 1ST SEMESTER EXAMINATION 2013/2014 SESSION #### INTRODUCTION TO GENERAL METABOLISM (MDB 203) (2 UNITS) * **DATE:** WEDNESDAY, 17TH SEPTEMBER 2014. * **TIME ALLOWED:** 2 HRS. * **INSTRUCTION** ANSWER THREE (3).QUESTIONS ONLY 1. a. Define the first and second laws of thermodynamics b. Define the following terms * Gibbs change in free energy * Entropy * Enthalpy c. i. What are oxidoreductases? ii. Distinguish between oxidases, dehydrogenases and oxygenases 2. a. What is the electron transfer potential of a redox system? b. Describe the relationship between free energy change and redox potential c. Given the following redox potentials in mammalian oxidation systems; * NAD+/NADH $E_o$'=+0.32 V * Pyruvate/lactate $E o$'= -0.19 V * i. Write a net balance equation for the two half reactions and calculate the redox potential (ΔΕ) between the two redox systems. * ii. Calculate the AG (in kJ/mol) for the net spontaneous redox reaction obtained from the two half reactions given that Faraday constant is 23.062 kcal V'mol and 1 cal = 4.187 J. * iii. Which of the two redox systems above will be oxidation and which will be reduction. * iv. Which of the biomolecules will be an oxidizing agent and which will be a reducing agent. # DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### IKEJA-LAGOS #### FIRST SEMESTER EXAMINATIONS 2019/2020 #### B.Sc. Physiology and Pharmacology ##### MDB 205: INTRODUCTION TO CHEMISTRY OF BIOCHEMICALLY IMPORTANT COMPOUNDS * **DATE:** 25/02/2021 * **TIME ALLOWED:** 2hrs. * **INSTRUCTION:** Answer All questions in SECTION A and SECTION B in separate booklet. #### SECTION A 1. a. Define Thermodynamics. b. State the 1st and 2nd laws of Thermodynamics c. Write short notes on the following Thermodynamic quantities. * dG * dH * dS * State the relationship between dG, dH and dS 2. a. Define Metabolism. 3. Write comprehensively on regulation of Metabolic pathways. #### SECTION B 1. a. Explain the term 'Cell' b. Compare and contrast the prokaryotic cell and eukaryotic cell. c. Mention 4 membranous organelles and list metabolic processes that occur in each of them. 2. a. Briefly Describe the anatomy of a mitochondrion and its functions. b. Briefly explain the role of the following complexes in electron transport chain (ETC): * Complex I * Complex II * Complex III * Complex IV # DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### IKEJA-LAGOS #### B.SC PHYSIOLOGY 1ST SEMESTER EXAMINATION 2013/2014 SESSION #### INTRODUCTION TO GENERAL METABOLISM (MOB 203) (2 UFGT.) * **DATE:** WEDNESDAY, 17TH SEPTEMBER 2014 **TIME ALLOWED:** 2 FIRS * **INSTRUCTION:** ANSWER THREE (3) QUESTIONS ONLY 1. a. Define the first and second laws of thermodynamics b. Define the following terms * Gibbs change in free energy * Entropy * Enthalpy c. i. What are oxidoreductases? ii. Distinguish between oxidases, dehydrogenases and oxygenases 2. a. What is the electron transfer potential of a redox system? b. Describe the relationship between free enegy change and redox potential c. Given the following redox potentials in mammalian oxidation systems; * NAD+/NADH $E_o$'= +0.32 V * Pyruvate/lactate $E o$'= -0.19 V * i. Write a net balance equation for the two hali reactions and calculate the redox potential (ΔΕ) between the two redox systems * ii. Calculate the AG (in kJ/mol) for the net spontaneous redox reaction obtained from the two half reactions given that Faraday constant is 23.062 kcal V'mol and 1 cal = 4.187 J. * iii. Which of the two redox systems above will be oxidation and which will be reduction. * iv. Which of the biomolecules will be an oxidizing agent and which will be a reducing agent. # DEPARTMENT OF MEDICAL BIOCHEMISTRY ## LAGOS STATE UNIVERSITY COLLEGE OF MEDICINE ### IKEJA-LAGOS #### B.Sc. (Hons.) PHYSIOLOGY 200 LEVEL HARMATTAN (1ST) SEMESTER 2014/2015 #### SESSION EXAMINATIONS ##### MDB 203: INTRODUCTION TO GENERAL METABOLISM. * **TIME ALLOWED:** 2 HOURS * **DATE:** WEDNESDAY, 29TH JULY, 2015 * **INSTRUCTIONS:** ANSWER ANY THREE QUESTIONS. ALL QUESTIONS CARRY EQUAL MARKS 1. a. Briefly describe using appropriate examples the interphase between catabolism and anabolism in intermediary metabolism. b. What is the significance of ATP in Intermediary metabolism? 2. Write concisely on any TWO of the following: * a. Mechanism of Enzyme action. * b. Laws of Thermodynamics * c. Feed back: Inhibition. 3. a. What are Enzymes b. Briefly explain the attributes of enzymes and the factors affecting their reactions? 4. a. What do you understand by Bioenergetics? b. Briefly describe the following Types of Energy: potential, kinetic and chemical energy. 5. a. Briefly describe Metabolic Pathways using specific examples. b. Briefly differentiate between Cofactors and Active sites of Enzymes.