MCQs on Drug Metabolism PDF

Multiple Choice Questions (MCQs) 1. What is the primary role of metabolism in drug elimination? a) To increase lipid solubility b) To make drugs more hydrophilic c) To decrease drug activity permanently d) To enhance drug toxicity e) To store drugs in the liver 2. Which of the following describes...

Multiple Choice Questions (MCQs) 1. What is the primary role of metabolism in drug elimination? a) To increase lipid solubility b) To make drugs more hydrophilic c) To decrease drug activity permanently d) To enhance drug toxicity e) To store drugs in the liver 2. Which of the following describes a prodrug? a) A drug that is active upon administration b) A drug that requires metabolism to become active c) A drug that undergoes detoxification in the liver d) A drug that directly binds to receptors without metabolism e) A drug that is eliminated unchanged in the urine 3. Which reaction is NOT part of Phase I metabolism? a) Oxidation b) Reduction c) Hydrolysis d) Glucuronidation e) Dealkylation 4. Which enzyme system is primarily responsible for oxidative biotransformation? a) Esterases b) Cytochrome P450 c) Amylases d) Dehydrogenases e) Proteases 5. Where does the first-pass metabolism primarily occur? a) Kidney b) Liver c) Lungs d) Brain e) Skin 6. Which of the following drugs undergoes significant first-pass metabolism? a) Paracetamol b) Lidocaine c) Amoxicillin d) Aspirin e) Ceftriaxone 7. Phase II metabolism mainly serves to: a) Oxidize drug molecules b) Convert drugs into active metabolites c) Conjugate drugs to increase water solubility d) Reduce drugs into alcohol derivatives e) Facilitate passive diffusion across membranes 8. Which of the following is NOT a Phase II reaction? a) Glucuronidation b) Sulfation c) Acetylation d) Hydroxylation e) Glycine conjugation 9. Which of the following organs is NOT a major site for drug metabolism? a) Liver b) Intestinal mucosa c) Brain d) Kidney e) Lungs 10. Aromatic hydroxylation in drug metabolism primarily results in the formation of: a) Ketones b) Carboxylic acids c) Phenolic metabolites d) Amides e) Alcohols  Correct Answers 1. b) To make drugs more hydrophilic 2. b) A drug that requires metabolism to become active 3. d) Glucuronidation 4. b) Cytochrome P450 5. b) Liver 6. b) Lidocaine 7. c) Conjugate drugs to increase water solubility 8. d) Hydroxylation 9. c) Brain 10. c) Phenolic metabolites