Atropine Sulfate Drug Profile PDF

GENERIC NAME atropine sulfate CLASSES • Anticholinergic • Parasympathetic blocker • Antidote STANDARD SUPPLIES • Prefilled syringe • Vial MECHANISMS OF ACTION • Blocks the action of acetylcholine • Increases the heart rate • Reverses the symptoms of cholinergic poisoning INDICATIONS • Hemodynamical...

GENERIC NAME atropine sulfate CLASSES • Anticholinergic • Parasympathetic blocker • Antidote STANDARD SUPPLIES • Prefilled syringe • Vial MECHANISMS OF ACTION • Blocks the action of acetylcholine • Increases the heart rate • Reverses the symptoms of cholinergic poisoning INDICATIONS • Hemodynamically significant bradycardia • Organophosphate poisoning • Carbamate poisoning • Nerve agent exposure CONTRAINDICATIONS • Known hypersensitivity to the drug • Tachycardia • Hypothermia-induced hemodynamically significant bradycardia ADVERSE REACTIONS/SIDE EFFECTS • Tachycardia • Palpitations • Flushed, hot, dry skin • Dizziness • Drowsiness • Confusion • Anxiety • Headache • Dilated pupils • Blurred vision • Dry mouth • Nausea • Vomiting ATROPINE SULFATE 1 ROUTES OF ADMINISTRATION • IV • IO • ET ONSET OF ACTION • Immediate ADULT DOSAGES • Hemodynamically significant bradycardia: 1.0 mg • May repeat the dosage every 3 to 5 minutes to maximum dosage 3.0 mg • Organophosphate poisoning/carbamate poisoning/nerve agent exposure: 1.0 to 4.0 mg • May double the dosage every 5 minutes • ET: 2.0 to 2.5 mg diluted in 10 mL normal saline PEDIATRIC DOSAGES • Hemodynamically significant bradycardia: 0.02 mg/kg • May repeat the dosage every 3 to 5 minutes to maximum dosage 1.0 mg in children and 2.0 mg in adolescents • Organophosphate poisoning/carbamate poisoning/nerve agent exposure: 0.03 to 0.05 mg/kg every 10 to 20 minutes SPECIAL CONSIDERATION • Consider transcutaneous pacing for bradydysrhythmias refractory to administration of the drug ATROPINE SULFATE 2