Malignant Hyperthermia Slides PDF
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Edge Hill University
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This document details malignant hyperthermia, a life-threatening medical condition affecting skeletal muscle. It explains the process of normal skeletal muscle contraction, including the roles of various ions like sodium and calcium, and the energy source ATP. It's likely a medical course or textbook.
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Buiding SCHEMATA with the Malignant Hyperthermia slides… Buiding SCHEMATA with the Malignant Hyperthermia slides.docx Page 1 of 9 This preview may have altered the layout of this file. You can still download the original file. Building SCHEM...
Buiding SCHEMATA with the Malignant Hyperthermia slides… Buiding SCHEMATA with the Malignant Hyperthermia slides.docx Page 1 of 9 This preview may have altered the layout of this file. You can still download the original file. Building SCHEMATA with Malignant Hyperthermia Slides Malignant Hyperthermia is when the Skeletal muscles contract excessively, producing heat and excessive C02 and tachycardia. It is a life-threatening hyperthermic reaction to GA (Gases and Succinylcholine). Let’s now learn how this all happens!! Normal skeletal muscle contraction Okay so far, we’ve been discussing the pattern before the neurotransmitter reaches partner receptor site and the effect of drugs at the receptor sites. But now we go further to discuss the ions involved after the neurotransmitter has entered the receptor. Think of: Sodium (Na+): The initiator ion which kickstarts Ca++ Calcium (Ca++): Main contraction (Squeeze) ion Adenosine Triphosphate (ATP): eats ions for energy (Just like we eat a biscuit and have to run 2 miles to burn it off (energy burns something!)) So now: Let’s think of normal skeletal muscle contraction 1. Ca++ is a big player in the contraction of skeletal muscle, but it’s not present in the cytoplasm (jelly part of the cell, where mitochondria and other bits float). It’s stored in the sarcoplasmic reticulum (SR) in muscle cells (Remember: It is important to store a picture in your mind to consider fixing it into your memory: I like the one below). Think of it as intracellular (inside the cell) saclike membranes. The tubes are actually thread like and are tubular constructs of muscle cell (Imagine a muscle cell with tubes inside and covering these like a web are sarcoplasmic reticulum) :
