Digestive System Lecture PDF

PowerPoint® Lecture Slides Prepared by Patty Bostwick-Taylor, Florence-Darlington Technical College CHAPTER 14 The Digestive...

PowerPoint® Lecture Slides Prepared by Patty Bostwick-Taylor, Florence-Darlington Technical College CHAPTER 14 The Digestive System and Body Metabolism © 2012 Pearson Education, Inc.  The Digestive System Functions Ingestion—taking in food Digestion—breaking food down both physically and chemically Absorption—movement of nutrients into the bloodstream Defecation—rids the body of indigestible waste © 2012 Pearson Education, Inc.  Organs of the Digestive System Two main groups of organs Alimentary canal (gastrointestinal or GI tract)—continuous coiled hollow tube These organs ingest, digest, absorb, defecate Accessory digestive organs Includes teeth, tongue, and other large digestive organs © 2012 Pearson Education, Inc.  Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary glands Submandibular gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending Small intestine Jejunum colon Ascending lleum colon Large intestine Cecum Sigmoid colon Rectum Appendix Anus Anal canal © 2012 Pearson Education, Inc. Figure 14.1  Organs of the Alimentary Canal Mouth Pharynx Esophagus Stomach Small intestine Large intestine Anus © 2012 Pearson Education, Inc.  Mouth (Oral Cavity) Anatomy Lips (labia)—protect the anterior opening Cheeks—form the lateral walls Hard palate—forms the anterior roof Soft palate—forms the posterior roof Uvula—fleshy projection of the soft palate © 2012 Pearson Education, Inc.  Mouth (Oral Cavity) Anatomy Vestibule—space between lips externally and teeth and gums internally Oral cavity proper—area contained by the teeth Tongue—attached at hyoid bone and styloid processes of the skull, and by the lingual frenulum to the floor of the mouth Tonsils Palatine—located at posterior end of oral cavity Lingual—located at the base of the tongue © 2012 Pearson Education, Inc.  Nasopharynx Hard palate Soft palate Oral cavity Uvula Lips (labia) Palatine tonsil Vestibule Lingual tonsil Oropharynx Lingual frenulum Epiglottis Tongue Laryngopharynx Hyoid bone Esophagus Trachea (a) © 2012 Pearson Education, Inc. Figure 14.2a  Upper lip Gingivae Hard palate (gums) Soft palate Uvula Palatine tonsil Oropharynx Tongue (b) © 2012 Pearson Education, Inc. Figure 14.2b  Mouth Physiology Mastication (chewing) of food Mixing masticated food with saliva Initiation of swallowing by the tongue Allows for the sense of taste © 2012 Pearson Education, Inc.  Pharynx Anatomy Nasopharynx—not part of the digestive system Oropharynx—posterior to oral cavity Laryngopharynx—below the oropharynx and connected to the esophagus © 2012 Pearson Education, Inc.  Nasopharynx Hard palate Soft palate Oral cavity Uvula Lips (labia) Palatine tonsil Vestibule Lingual tonsil Oropharynx Lingual frenulum Epiglottis Tongue Laryngopharynx Hyoid bone Esophagus Trachea (a) © 2012 Pearson Education, Inc. Figure 14.2a  Pharynx Physiology Serves as a passageway for air and food Food is propelled to the esophagus by two muscle layers Longitudinal inner layer Circular outer layer Food movement is by alternating contractions of the muscle layers (peristalsis) © 2012 Pearson Education, Inc.  Esophagus Anatomy and Physiology Anatomy About 10 inches long Runs from pharynx to stomach through the diaphragm Physiology Conducts food by peristalsis (slow rhythmic squeezing) Passageway for food only (respiratory system branches off after the pharynx) © 2012 Pearson Education, Inc.  Layers of Tissue in the Alimentary Canal Organs Four layers from deep to superficial: Mucosa Submucosa Muscularis externa Serosa © 2012 Pearson Education, Inc.  Layers of Tissue in the Alimentary Canal Organs Mucosa Innermost, moist membrane consisting of Surface epithelium Small amount of connective tissue (lamina propria) Small smooth muscle layer Lines the cavity (known as the lumen) © 2012 Pearson Education, Inc.  Visceral peritoneum Intrinsic nerve plexuses Myenteric nerve plexus Submucosal nerve plexus Submucosal glands Mucosa Surface epithelium Lamina propria Muscle layer Submucosa Muscularis externa Longitudinal muscle layer Circular muscle layer Serosa (visceral peritoneum) Nerve Gland in Artery Lumen Mesenter y mucosa Vein Duct of gland Lymphoid tissue outside alimentary canal © 2012 Pearson Education, Inc. Figure 14.3  Layers of Tissue in the Alimentary Canal Organs Submucosa Just beneath the mucosa Soft connective tissue with blood vessels, nerve endings, mucosa-associated lymphoid tissue, and lymphatics © 2012 Pearson Education, Inc.  Visceral peritoneum Intrinsic nerve plexuses Myenteric nerve plexus Submucosal nerve plexus Submucosal glands Mucosa Surface epithelium Lamina propria Muscle layer Submucosa Muscularis externa Longitudinal muscle layer Circular muscle layer Serosa (visceral peritoneum) Nerve Gland in Artery Lumen Mesenter y mucosa Vein Duct of gland Lymphoid tissue outside alimentary canal © 2012 Pearson Education, Inc. Figure 14.3  Layers of Tissue in the Alimentary Canal Organs Muscularis externa—smooth muscle Inner circular layer Outer longitudinal layer Serosa—outermost layer of the wall contains fluid-producing cells Visceral peritoneum—outermost layer that is continuous with the innermost layer Parietal peritoneum—innermost layer that lines the abdominopelvic cavity © 2012 Pearson Education, Inc.  Visceral peritoneum Intrinsic nerve plexuses Myenteric nerve plexus Submucosal nerve plexus Submucosal glands Mucosa Surface epithelium Lamina propria Muscle layer Submucosa Muscularis externa Longitudinal muscle layer Circular muscle layer Serosa (visceral peritoneum) Nerve Gland in Artery Lumen Mesenter y mucosa Vein Duct of gland Lymphoid tissue outside alimentary canal © 2012 Pearson Education, Inc. Figure 14.3  Diaphragm Falciform ligament Lesser Liver omentum Spleen Gallbladder Pancreas Stomach Duodenum Visceral peritoneum Transverse Greater omentum colon Mesenteries Parietal peritoneum Small intestine Peritoneal cavity Uterus Large intestine Cecum Rectum Anus Urinary bladder (a) (b) © 2012 Pearson Education, Inc. Figure 14.5  Alimentary Canal Nerve Plexuses Two important nerve plexuses serve the alimentary canal Both are part of the autonomic nervous system Submucosal nerve plexus Myenteric nerve plexus Function is to regulate mobility and secretory activity of the GI tract organs © 2012 Pearson Education, Inc.  Stomach Anatomy Located on the left side of the abdominal cavity Food enters at the cardioesophageal sphincter Food empties into the small intestine at the pyloric sphincter (valve) © 2012 Pearson Education, Inc.  Stomach Anatomy Regions of the stomach Cardiac region—near the heart Fundus—expanded portion lateral to the cardiac region Body—midportion Pylorus—funnel-shaped terminal end © 2012 Pearson Education, Inc.  Stomach Anatomy Rugae—internal folds of the mucosa Stomach can stretch and hold 4 L (1 gallon) of food when full External regions Lesser curvature—concave medial surface Greater curvature—convex lateral surface © 2012 Pearson Education, Inc.  Cardioesophageal sphincter Fundus Esophagus Muscularis externa Serosa Longitudinal layer Circular layer Body Oblique layer Lesser Rugae curvature of Pylorus mucosa Greater curvature Duodenum Pyloric Pyloric Sphincter antrum (a) (valve) © 2012 Pearson Education, Inc. Figure 14.4a  Fundus Body Rugae of mucosa (b) Pyloric Pyloric sphincter antrum © 2012 Pearson Education, Inc. Figure 14.4b  Stomach Anatomy Layers of peritoneum attached to the stomach Lesser omentum—attaches the liver to the lesser curvature Greater omentum—attaches the greater curvature to the posterior body wall Embedded fat insulates, cushions, and protects abdominal organs Lymph follicles contain macrophages Muscularis externa has a third layer Oblique layer helps to churn, mix, and pummel the food © 2012 Pearson Education, Inc.  Diaphragm Falciform ligament Liver Spleen Gallbladder Stomach Greater omentum Small intestine Large intestine Cecum (a) © 2012 Pearson Education, Inc. Figure 14.5a  Diaphragm Lesser Liver omentum Pancreas Stomach Duodenum Visceral peritoneum Transverse Greater omentum colon Mesenteries Parietal peritoneum Small intestine Peritoneal cavity Uterus Rectum Anus Urinary bladder (b) © 2012 Pearson Education, Inc. Figure 14.5b  Stomach Physiology Temporary storage tank for food Site of food breakdown Chemical breakdown of protein begins Delivers chyme (processed food) to the small intestine © 2012 Pearson Education, Inc.  Structure of the Stomach Mucosa Mucosa is simple columnar epithelium Mucous neck cells—produce a sticky alkaline mucus Gastric glands—situated in gastric pits and secrete gastric juice Chief cells—produce protein-digesting enzymes (pepsinogens) Parietal cells—produce hydrochloric acid Enteroendocrine cells—produce gastrin © 2012 Pearson Education, Inc.  Gastric pits Surface epithelium Gastric pit Pyloric sphincter Mucous neck cells Parietal cells Gastric gland Gastric glands Chief cells (c) © 2012 Pearson Education, Inc. Figure 14.4c  Pepsinogen Pepsin HCl Parietal cells Chief cells Enteroendocrine cell (d) © 2012 Pearson Education, Inc. Figure 14.4d  Small Intestine The body’s major digestive organ Site of nutrient absorption into the blood Muscular tube extending from the pyloric sphincter to the ileocecal valve Suspended from the posterior abdominal wall by the mesentery © 2012 Pearson Education, Inc.  Subdivisions of the Small Intestine Duodenum Attached to the stomach Curves around the head of the pancreas Jejunum Attaches anteriorly to the duodenum Ileum Extends from jejunum to large intestine © 2012 Pearson Education, Inc.  Chemical Digestion in the Small Intestine Chemical digestion begins in the small intestine Enzymes are produced by Intestinal cells Pancreas Pancreatic ducts carry enzymes to the small intestine Bile, formed by the liver, enters via the bile duct © 2012 Pearson Education, Inc.  Right and left hepatic ducts from liver Cystic duct Common hepatic Bileduct duct and sphincter Accessory pancreatic duct Pancreas Gallbladder Jejunum Duodenal papilla Hepatopancreatic Main pancreatic duct and sphincter ampulla and sphincter Duodenum © 2012 Pearson Education, Inc. Figure 14.6  Small Intestine Anatomy Three structural modifications that increase surface area Microvilli—tiny projections of the plasma membrane (create a brush border appearance) Villi—fingerlike structures formed by the mucosa Circular folds (plicae circulares)—deep folds of mucosa and submucosa © 2012 Pearson Education, Inc.  Blood vessels serving the small intestine Lumen Muscle layers Circular folds Villi (plicae circulares) (a) Small intestine © 2012 Pearson Education, Inc. Figure 14.7a  Absorptive cells Lacteal Villus Blood capillaries Lymphoid tissue Intestinal crypt Muscularis Venule mucosae Lymphatic vessel Submucosa (b) Villi © 2012 Pearson Education, Inc. Figure 14.7b  Microvilli (brush border) (c) Absorptive cells © 2012 Pearson Education, Inc. Figure 14.7c  Large Intestine Larger in diameter, but shorter in length, than the small intestine Extends from the ileocecal valve to the anus Subdivisions: Cecum Appendix Colon Rectum Anal canal © 2012 Pearson Education, Inc.  Large Intestine Anatomy Cecum—saclike first part of the large intestine Appendix Accumulation of lymphatic tissue that sometimes becomes inflamed (appendicitis) Hangs from the cecum © 2012 Pearson Education, Inc.  Left colic (splenic) flexure Transverse Right colic mesocolon (hepatic) flexure Transverse colon Haustrum Descending colon Ascending colon IIeum (cut) Cut edge of mesentery IIeocecal valve Teniae coli Sigmoid colon Cecum Appendix Rectum Alan canal External anal sphincter © 2012 Pearson Education, Inc. Figure 14.8  Large Intestine Anatomy Colon Ascending—travels up right side of abdomen Transverse—travels across the abdominal cavity Descending—travels down the left side Sigmoid—S-shaped region; enters the pelvis Rectum and anus also are located in the pelvis © 2012 Pearson Education, Inc.  Left colic (splenic) flexure Transverse Right colic mesocolon (hepatic) flexure Transverse colon Haustrum Descending colon Ascending colon IIeum (cut) Cut edge of mesentery IIeocecal valve Teniae coli Sigmoid colon Cecum Appendix Rectum Alan canal External anal sphincter © 2012 Pearson Education, Inc. Figure 14.8  Large Intestine Anatomy Anus—opening of the large intestine External anal sphincter—formed by skeletal muscle and under voluntary control Internal involuntary sphincter—formed by smooth muscle These sphincters are normally closed except during defecation © 2012 Pearson Education, Inc.  Left colic (splenic) flexure Transverse Right colic mesocolon (hepatic) flexure Transverse colon Haustrum Descending colon Ascending colon IIeum (cut) Cut edge of mesentery IIeocecal valve Teniae coli Sigmoid colon Cecum Appendix Rectum Alan canal External anal sphincter © 2012 Pearson Education, Inc. Figure 14.8  Large Intestine Anatomy No villi present Goblet cells produce alkaline mucus which lubricates the passage of feces Muscularis externa layer is reduced to three bands of muscle called teniae coli These bands cause the wall to pucker into haustra (pocketlike sacs) © 2012 Pearson Education, Inc.  Accessory Digestive Organs Teeth Salivary glands Pancreas Liver Gallbladder © 2012 Pearson Education, Inc.  Teeth Function is to masticate (chew) food Humans have two sets of teeth Deciduous (baby or “milk”) teeth A baby has 20 teeth by age two First teeth to appear are the lower central incisors © 2012 Pearson Education, Inc.  Teeth Permanent teeth Replace deciduous teeth between the ages of 6 and 12 A full set is 32 teeth, but some people do not have wisdom teeth (third molars) If they do emerge, the wisdom teeth appear between ages of 17 and 25 © 2012 Pearson Education, Inc.  Classification of Teeth Incisors—cutting Canines (eyeteeth)—tearing or piercing Premolars (bicuspids)—grinding Molars—grinding © 2012 Pearson Education, Inc.  Incisors Central (6–8 mo) Lateral (8–10 mo) Canine (eyetooth) (16–20 mo) Molars First molar (10–15 mo) Second molar (about 2 yr) Deciduous (milk) teeth Incisors Central (7 yr) Lateral (8 yr) Canine (eyetooth) (11 yr) Premolars (bicuspids) First premolar (11 yr) Second premolar (12–13 yr) Molars First molar (6–7 yr) Second molar Permanent (12–13 yr) teeth Third molar (wisdom tooth) (17–25 yr) © 2012 Pearson Education, Inc. Figure 14.9  Regions of a Tooth Crown—exposed part Enamel—hardest substance in the body Dentin—found deep to the enamel and forms the bulk of the tooth Pulp cavity—contains connective tissue, blood vessels, and nerve fibers Root canal—where the pulp cavity extends into the root © 2012 Pearson Education, Inc.  Regions of a Tooth Neck Region in contact with the gum Connects crown to root Root Cementum—covers outer surface and attaches the tooth to the periodontal membrane © 2012 Pearson Education, Inc.  Enamel Crown Dentin Pulp cavity Gum Neck (gingiva) Periodontal membrane Bone Root Cement Root canal Blood vessels and nerves in pulp © 2012 Pearson Education, Inc. Figure 14.10  Salivary Glands Three pairs of salivary glands empty secretions into the mouth Parotid glands Found anterior to the ears Submandibular glands Sublingual glands Both submandibular and sublingual glands empty saliva into the floor of the mouth through small ducts © 2012 Pearson Education, Inc.  Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary glands Submandibular gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending Small intestine Jejunum colon Ascending lleum colon Large intestine Cecum Sigmoid colon Rectum Appendix Anus Anal canal © 2012 Pearson Education, Inc. Figure 14.1  Saliva Mixture of mucus and serous fluids Helps to form a food bolus Contains salivary amylase to begin starch digestion Dissolves chemicals so they can be tasted © 2012 Pearson Education, Inc.  Pancreas Found posterior to the parietal peritoneum Its location is retroperitoneal Extends across the abdomen from spleen to duodenum © 2012 Pearson Education, Inc.  Pancreas Produces a wide spectrum of digestive enzymes that break down all categories of food Enzymes are secreted into the duodenum Alkaline fluid introduced with enzymes neutralizes acidic chyme coming from stomach Hormones produced by the pancreas Insulin Glucagon © 2012 Pearson Education, Inc.  Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary glands Submandibular gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending Small intestine Jejunum colon Ascending lleum colon Large intestine Cecum Sigmoid colon Rectum Appendix Anus Anal canal © 2012 Pearson Education, Inc. Figure 14.1  Right and left hepatic ducts from liver Cystic duct Common hepatic Bileduct duct and sphincter Accessory pancreatic duct Pancreas Gallbladder Jejunum Duodenal papilla Hepatopancreatic Main pancreatic duct and sphincter ampulla and sphincter Duodenum © 2012 Pearson Education, Inc. Figure 14.6  Liver Largest gland in the body Located on the right side of the body under the diaphragm Consists of four lobes suspended from the diaphragm and abdominal wall by the falciform ligament Connected to the gallbladder via the common hepatic duct © 2012 Pearson Education, Inc.  Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary glands Submandibular gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending Small intestine Jejunum colon Ascending lleum colon Large intestine Cecum Sigmoid colon Rectum Appendix Anus Anal canal © 2012 Pearson Education, Inc. Figure 14.1  Diaphragm Falciform ligament Lesser Liver omentum Spleen Gallbladder Pancreas Stomach Duodenum Visceral peritoneum Transverse Greater omentum colon Mesenteries Parietal peritoneum Small intestine Peritoneal cavity Uterus Large intestine Cecum Rectum Anus Urinary bladder (a) (b) © 2012 Pearson Education, Inc. Figure 14.5a-b  Bile Produced by cells in the liver Bile leaves the liver through the common hepatic duct Composition is Bile salts Bile pigments (mostly bilirubin from the breakdown of hemoglobin) Cholesterol Phospholipids Electrolytes © 2012 Pearson Education, Inc.  Bile Function—emulsify fats by physically breaking large fat globules into smaller ones © 2012 Pearson Education, Inc.  Gallbladder Sac found in hollow fossa of liver When no digestion is occurring, bile backs up the cystic duct for storage in the gallbladder When digestion of fatty food is occurring, bile is introduced into the duodenum from the gallbladder Gallstones are crystallized cholesterol which can cause blockages © 2012 Pearson Education, Inc.  Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary glands Submandibular gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending Small intestine Jejunum colon Ascending lleum colon Large intestine Cecum Sigmoid colon Rectum Appendix Anus Anal canal © 2012 Pearson Education, Inc. Figure 14.1  Right and left hepatic ducts from liver Cystic duct Common hepatic Bileduct duct and sphincter Accessory pancreatic duct Pancreas Gallbladder Jejunum Duodenal papilla Hepatopancreatic Main pancreatic duct and sphincter ampulla and sphincter Duodenum © 2012 Pearson Education, Inc. Figure 14.6  Functions of the Digestive System Ingestion—placing food into the mouth Propulsion—moving foods from one region of the digestive system to another Peristalsis—alternating waves of contraction and relaxation that squeezes food along the GI tract Segmentation—moving materials back and forth to aid with mixing in the small intestine © 2012 Pearson Education, Inc.  Ingestion Food Mechanical digestion Pharynx Chewing (mouth) Esophagus Churning (stomach) Propulsion Segmentation Swallowing (small intestine) (oropharynx) Chemical Peristalsis digestion (esophagus, stomach, small intestine, large intestine) Stomach Absorption Lymph vessel Small intestine Large Blood intestine vessel Mainly H2O Feces Anus Defecation © 2012 Pearson Education, Inc. Figure 14.11 © 2012 Pearson Education, Inc. Figure 14.12a-b  Functions of the Digestive System Food breakdown as mechanical digestion Examples: Mixing food in the mouth by the tongue Churning food in the stomach Segmentation in the small intestine Mechanical digestion prepares food for further degradation by enzymes © 2012 Pearson Education, Inc.  Functions of the Digestive System Food breakdown as chemical digestion Enzymes break down food molecules into their building blocks Each major food group uses different enzymes Carbohydrates are broken to simple sugars Proteins are broken to amino acids Fats are broken to fatty acids and alcohols © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Figure 14.13 (1 of 3) © 2012 Pearson Education, Inc. Figure 14.13 (2 of 3) © 2012 Pearson Education, Inc. Figure 14.13 (3 of 3)  Functions of the Digestive System Absorption End products of digestion are absorbed in the blood or lymph Food must enter mucosal cells and then into blood or lymph capillaries Defecation Elimination of indigestible substances from the GI tract in the form of feces © 2012 Pearson Education, Inc.  Ingestion Food Mechanical digestion Pharynx Chewing (mouth) Esophagus Churning (stomach) Propulsion Segmentation Swallowing (small intestine) (oropharynx) Chemical Peristalsis digestion (esophagus, stomach, small intestine, large intestine) Stomach Absorption Lymph vessel Small intestine Large Blood intestine vessel Mainly H2O Feces Anus Defecation © 2012 Pearson Education, Inc. Figure 14.11  Control of Digestive Activity Mostly controlled by reflexes via the parasympathetic division Chemical and mechanical receptors are located in organ walls that trigger reflexes © 2012 Pearson Education, Inc.  Control of Digestive Activity Stimuli include Stretch of the organ pH of the contents Presence of breakdown products Reflexes include Activation or inhibition of glandular secretions Smooth muscle activity © 2012 Pearson Education, Inc.  Digestive Activities of the Mouth Mechanical breakdown Food is physically broken down by chewing Chemical digestion Food is mixed with saliva Starch is broken down into maltose by salivary amylase © 2012 Pearson Education, Inc.  Activities of the Pharynx and Esophagus These organs have no digestive function Serve as passageways to the stomach © 2012 Pearson Education, Inc.  Deglutition (Swallowing) Buccal phase Voluntary Occurs in the mouth Food is formed into a bolus The bolus is forced into the pharynx by the tongue © 2012 Pearson Education, Inc.  Deglutition (Swallowing) Pharyngeal-esophageal phase Involuntary transport of the bolus All passageways except to the stomach are blocked Tongue blocks off the mouth Soft palate (uvula) blocks the nasopharynx Epiglottis blocks the larynx © 2012 Pearson Education, Inc.  Deglutition (Swallowing) Pharyngeal-esophogeal phase (continued) Peristalsis moves the bolus toward the stomach The cardioesophageal sphincter is opened when food presses against it © 2012 Pearson Education, Inc.  Bolus of food Tongue Pharynx Epiglottis Upper up esophageal Glottis (lumen) sphincter of larynx Trachea Esophagus (a) Upper esophageal sphincter contracted © 2012 Pearson Education, Inc. Figure 14.14a  Uvula Bolus Epiglottis down Larynx up Esophagus (b) Upper esophageal © 2012 Pearson Education, Inc. sphincter relaxed Figure 14.14b  Bolus (c) Upper esophageal sphincter contracted © 2012 Pearson Education, Inc. Figure 14.14c  Relaxed muscles Cardioesophageal sphincter open (d) Cardioesophageal sphincter relaxed © 2012 Pearson Education, Inc. Figure 14.14d  Food Breakdown in the Stomach Gastric juice is regulated by neural and hormonal factors Presence of food or rising pH causes the release of the hormone gastrin Gastrin causes stomach glands to produce Protein-digesting enzymes Mucus Hydrochloric acid © 2012 Pearson Education, Inc.  Food Breakdown in the Stomach Hydrochloric acid makes the stomach contents very acidic Acidic pH Activates pepsinogen to pepsin for protein digestion Provides a hostile environment for microorganisms © 2012 Pearson Education, Inc.  Digestion and Absorption in the Stomach Protein digestion enzymes Pepsin—an active protein-digesting enzyme Rennin—works on digesting milk protein in infants, not adults Alcohol and aspirin are the only items absorbed in the stomach © 2012 Pearson Education, Inc.  Propulsion in the Stomach Food must first be well mixed Rippling peristalsis occurs in the lower stomach Propulsion Grinding Retropulsion The pylorus meters out chyme into the small intestine (3 mL at a time) The stomach empties in 4–6 hours © 2012 Pearson Education, Inc.  Pyloric Pyloric Pyloric sphincter sphincter sphincter slightly closed closed open 1 Propulsion: Peristaltic 2 Grinding: The most 3 Retropulsion: The pyloric waves move from the vigorous peristalsis and end of the stomach pumps fundus to the pylorus. mixing action occur close small amounts of chyme to the pylorus. into the duodenum, while simultaneously forcing most of its contents backward into the stomach. © 2012 Pearson Education, Inc. Figure 14.15  Digestion in the Small Intestine Enzymes from the brush border function to Break double sugars into simple sugars Complete some protein digestion © 2012 Pearson Education, Inc.  Digestion in the Small Intestine Pancreatic enzymes play the major digestive function Help complete digestion of starch (pancreatic amylase) Carry out about half of all protein digestion Digest fats using lipases from the pancreas Digest nucleic acids using nucleases Alkaline content neutralizes acidic chyme © 2012 Pearson Education, Inc.  Regulation of Pancreatic Juice Secretion Release of pancreatic juice into the duodenum is stimulated by Vagus nerve Local hormones Secretin Cholecystokinin (CCK) Hormones travel the blood to stimulate the pancreas to release enzyme- and bicarbonate-rich product © 2012 Pearson Education, Inc.  Regulation of Pancreatic Juice Secretion Secretin causes the liver to increase bile output CCK causes the gallbladder to release stored bile Bile is necessary for fat absorption and absorption of fat-soluble vitamins (K, D, A) © 2012 Pearson Education, Inc.  5 Stimulation by vagal nerve 4 Secretin causes the liver to fibers causes release of secrete more bile; CCK stimulates pancreatic juice and weak the gallbladder to release stored contractions of the gallbladder. bile and the hepatopancreatic sphincter to relax (allows bile to enter the duodenum). 1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). 2 CCK (red dots) and secretin (blue dots) enter bloodstream. 3 Upon reaching the pancreas, CCK induces secretion of enzyme-rich pancreatic juice; secretin causes secretion of bicarbonate- rich pancreatic juice. © 2012 Pearson Education, Inc. Figure 14.16  1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). © 2012 Pearson Education, Inc. Figure 14.16, step 1  1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). 2 CCK (red dots) and secretin (blue dots) enter bloodstream. © 2012 Pearson Education, Inc. Figure 14.16, step 2  1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). 2 CCK (red dots) and secretin (blue dots) enter bloodstream. 3 Upon reaching the pancreas, CCK induces secretion of enzyme-rich pancreatic juice; secretin causes secretion of bicarbonate- rich pancreatic juice. © 2012 Pearson Education, Inc. Figure 14.16, step 3  4 Secretin causes the liver to secrete more bile; CCK stimulates the gallbladder to release stored bile and the hepatopancreatic sphincter to relax (allows bile to enter the duodenum). 1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). 2 CCK (red dots) and secretin (blue dots) enter bloodstream. 3 Upon reaching the pancreas, CCK induces secretion of enzyme-rich pancreatic juice; secretin causes secretion of bicarbonate- rich pancreatic juice. © 2012 Pearson Education, Inc. Figure 14.16, step 4  5 Stimulation by vagal nerve 4 Secretin causes the liver to fibers causes release of secrete more bile; CCK stimulates pancreatic juice and weak the gallbladder to release stored contractions of the gallbladder. bile and the hepatopancreatic sphincter to relax (allows bile to enter the duodenum). 1 Chyme entering duodenum causes the enteroendocrine cells of the duodenum to release secretin and cholecystokinin (CCK). 2 CCK (red dots) and secretin (blue dots) enter bloodstream. 3 Upon reaching the pancreas, CCK induces secretion of enzyme-rich pancreatic juice; secretin causes secretion of bicarbonate- rich pancreatic juice. © 2012 Pearson Education, Inc. Figure 14.16, step 5  Absorption in the Small Intestine Water is absorbed along the length of the small intestine End products of digestion Most substances are absorbed by active transport through cell membranes Lipids are absorbed by diffusion Substances are transported to the liver by the hepatic portal vein or lymph © 2012 Pearson Education, Inc.  Propulsion in the Small Intestine Peristalsis is the major means of moving food Segmental movements Mix chyme with digestive juices Aid in propelling food © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Figure 14.12b  Food Breakdown and Absorption in the Large Intestine No digestive enzymes are produced Resident bacteria digest remaining nutrients Produce some vitamin K and B Release gases Water and vitamins K and B are absorbed Remaining materials are eliminated via feces © 2012 Pearson Education, Inc.  Food Breakdown and Absorption in the Large Intestine Feces contains Undigested food residues Mucus Bacteria Water © 2012 Pearson Education, Inc.  Propulsion in the Large Intestine Sluggish peristalsis Mass movements Slow, powerful movements Occur three to four times per day Presence of feces in the rectum causes a defecation reflex Internal anal sphincter is relaxed Defecation occurs with relaxation of the voluntary (external) anal sphincter © 2012 Pearson Education, Inc.  Nutrition Nutrient—substance used by the body for growth, maintenance, and repair Major nutrients Carbohydrates Lipids Proteins Water Minor nutrients Vitamins Minerals © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Figure 14.17  Dietary Sources of Major Nutrients Carbohydrates Most are derived from plants Exceptions: lactose from milk and small amounts of glycogens from meats Lipids Saturated fats from animal products Unsaturated fats from nuts, seeds, and vegetable oils Cholesterol from egg yolk, meats, and milk products © 2012 Pearson Education, Inc.  Dietary Sources of Major Nutrients Proteins Complete proteins—contain all essential amino acids Most are from animal products Essential amino acids are ones that our bodies cannot make We must obtain essential amino acids through our diet Legumes and beans also have proteins, but are incomplete © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Figure 14.18  Dietary Sources of Major Nutrients Vitamins Most vitamins are used as coenzymes Found in all major food groups © 2012 Pearson Education, Inc.  Dietary Sources of Major Nutrients Minerals Play many roles in the body Most mineral-rich foods are vegetables, legumes, milk, and some meats © 2012 Pearson Education, Inc.  Metabolism Chemical reactions necessary to maintain life Catabolism—substances are broken down to simpler substances; energy is released Anabolism—larger molecules are built from smaller ones © 2012 Pearson Education, Inc.  Carbohydrate Metabolism Carbohydrates are the body’s preferred source to produce cellular energy (ATP) Glucose (blood sugar) Major breakdown product of carbohydrate digestion Fuel used to make ATP © 2012 Pearson Education, Inc.  Cellular Respiration Oxygen-using events take place within the cell to create ATP from ADP Carbon leaves cells as carbon dioxide (CO2) Hydrogen atoms are combined with oxygen to form water Energy produced by these reactions adds a phosphorus to ADP to produce ATP ATP can be broken down to release energy for cellular use © 2012 Pearson Education, Inc. © 2012 Pearson Education, Inc. Figure 14.19  Metabolic Pathways Involved in Cellular Respiration Glycolysis—energizes a glucose molecule so it can be split into two pyruvic acid molecules and yield ATP © 2012 Pearson Education, Inc.  Chemical energy (high-energy electrons) CO2 Chemical energy CO2 Electron transport Glycolysis chain and oxidative Pyruvic Krebs phosphorylation Glucose cycle H2O acid Mitochondrion Cytosol Mitochondrial of cell cristae Via oxidative phosphorylation Via substrate-level phosphorylation 2 2 28 ATP ATP ATP 1 During glycolysis, each 2 The pyruvic acid enters 3 Energy-rich electrons picked up by glucose molecule is the mitochondrion where coenzymes are transferred to the electron broken down into two Krebs cycle enzymes transport chain, built into the cristae molecules of pyruvic acid remove more hydrogen membrane. The electron transport chain as hydrogen atoms atoms and decompose it to carries out oxidative phosphorylation, containing high-energy CO2. During glycolysis and which accounts for most of the ATP electrons are removed. the Krebs cycle, small generated by cellular respiration, and amounts of ATP are formed. finally unites the removed hydrogen with oxygen to form water. © 2012 Pearson Education, Inc. Figure 14.20  Chemical energy (high-energy electrons) Glycolysis Pyruvic Glucose acid Mitochondrion Cytosol Mitochondrial of cell cristae Via substrate-level phosphorylation 2 ATP 1 During glycolysis, each glucose molecule is broken down into two molecules of pyruvic acid as hydrogen atoms containing high-energy electrons are removed. © 2012 Pearson Education, Inc. Figure 14.20, step 1  Metabolic Pathways Involved in Cellular Respiration Krebs cycle Produces virtually all the carbon dioxide and water resulting from cell respiration Yields a small amount of ATP © 2012 Pearson Education, Inc.  Chemical energy (high-energy electrons) CO2 Chemical energy CO2 Glycolysis Pyruvic Krebs Glucose acid cycle Mitochondrion Cytosol Mitochondrial of cell cristae Via substrate-level phosphorylation 2 2 ATP ATP 1 During glycolysis, each 2 The pyruvic acid enters glucose molecule is the mitochondrion where broken down into two Krebs cycle enzymes molecules of pyruvic acid remove more hydrogen as hydrogen atoms atoms and decompose it to containing high-energy CO2. During glycolysis and electrons are removed. the Krebs cycle, small amounts of ATP are formed. © 2012 Pearson Education, Inc. Figure 14.20, step 2  Metabolic Pathways Involved in Cellular Respiration Electron transport chain Hydrogen atoms removed during glycolysis and the Krebs cycle are delivered to protein carriers Hydrogen is split into hydrogen ions and electrons in the mitochondria Electrons give off energy in a series of steps to enable the production of ATP © 2012 Pearson Education, Inc.  Chemical energy (high-energy electrons) CO2 Chemical energy CO2 Electron transport Glycolysis chain and oxidative Pyruvic Krebs phosphorylation Glucose cycle H2O acid Mitochondrion Cytosol Mitochondrial of cell cristae Via oxidative phosphorylation Via substrate-level phosphorylation 2 2 28 ATP ATP ATP 1 During glycolysis, each 2 The pyruvic acid enters 3 Energy-rich electrons picked up by glucose molecule is the mitochondrion where coenzymes are transferred to the electron broken down into two Krebs cycle enzymes transport chain, built into the cristae molecules of pyruvic acid remove more hydrogen membrane. The electron transport chain as hydrogen atoms atoms and decompose it to carries out oxidative phosphorylation, containing high-energy CO2. During glycolysis and which accounts for most of the ATP electrons are removed. the Krebs cycle, small generated by cellular respiration, and amounts of ATP are formed. finally unites the removed hydrogen with oxygen to form water. © 2012 Pearson Education, Inc. Figure 14.20, step 3  NADH NAD+ + H+ Energy released as heat and light Ene r avai gy relea 2e– lable se for m d and n akin o g AT w P of th P e ele rotein c ctro a n tra rriers nspo rt chai n e– Electron flow O2 (a) (b) © 2012 Pearson Education, Inc. Figure 14.21a-b  Metabolism of Carbohydrates Hyperglycemia—excessively high levels of glucose in the blood Excess glucose is stored in body cells as glycogen If blood glucose levels are still too high, excesses are converted to fat © 2012 Pearson Education, Inc.  (a) Carbohydrates: polysaccharides, disaccharides; composed of simple sugars (monosaccharides) ATP Glycogen and fat Polysaccharides Cellular uses broken down for ATP formation GI digestion to To Excess stored as simple sugars capillary glycogen or fat Broken down to glucose Monosaccharides and released to blood © 2012 Pearson Education, Inc. Figure 14.22a  Metabolism of Carbohydrates Hypoglycemia—low levels of glucose in the blood Liver breaks down stored glycogen and releases glucose into the blood © 2012 Pearson Education, Inc.  Fat Metabolism Handled mostly by the liver Uses some fats to make ATP Synthesizes lipoproteins, thromboplastin, and cholesterol Releases breakdown products to the blood Body cells remove fat and cholesterol to build membranes and steroid hormones © 2012 Pearson Education, Inc.  Use of Fats for ATP Synthesis Fats must first be broken down to acetic acid Within mitochondria, acetic acid is completely oxidized to produce water, carbon dioxide, and ATP © 2012 Pearson Education, Inc.  (d) ATP formation (fueling the metabolic furnace): all categories of food can be oxidized to provide energy molecules Carbon (ATP) dioxide Cellular Monosaccharides metabolic “furnace”: Water Krebs cycle Fatty acids and electron transport Amino acids chain ATP (amine first removed and combined with CO2 by the liver to form urea) © 2012 Pearson Education, Inc. Figure 14.22d  Fat Metabolism Acidosis (ketoacidosis) results from incomplete fat oxidation in which acetoacetic acid and acetone accumulate in the blood Breath has a fruity odor Common with “No carbohydrate” diets Uncontrolled diabetes mellitus Starvation © 2012 Pearson Education, Inc.  (b) Fats: composed of 1 glycerol molecule and 3 fatty acids; triglycerides Cellular ATP Fats are the Metabolized uses primary fuels Lipid (fat) by liver to in many cells Fatty acetic acid, etc. acids GI digestion to fatty acids and glycerol Insulation and fat Fats build myelin cushions to protect sheaths and cell body organs membranes Glycerol © 2012 Pearson Education, Inc. Figure 14.22b  Protein Metabolism Proteins are conserved by body cells because they are used for most cellular structures Ingested proteins are broken down to amino acids © 2012 Pearson Education, Inc.  Protein Metabolism Cells remove amino acids to build proteins Synthesized proteins are actively transported across cell membranes Amino acids are used to make ATP only when proteins are overabundant or there is a shortage of other sources © 2012 Pearson Education, Inc.  Production of ATP from Protein Amine groups are removed from proteins as ammonia The rest of the protein molecule enters the Krebs cycle in mitochondria The liver converts harmful ammonia to urea which can be eliminated in urine © 2012 Pearson Education, Inc.  (c) Proteins: polymers of amino acids ATP formation if inadequate ATP glucose and fats or if essential Protein Normally amino acids are lacking infrequent Functional proteins GI digestion to (enzymes, antibodies, amino acids Cellular hemoglobin, etc.) uses Structural proteins Amino (connective tissue fibers, acids muscle proteins, etc.) © 2012 Pearson Education, Inc. Figure 14.22c  Role of the Liver in Metabolism Several roles in digestion Manufactures bile Detoxifies drugs and alcohol Degrades hormones Produces cholesterol, blood proteins (albumin and clotting proteins) Plays a central role in metabolism Can regenerate if part of it is damaged or removed © 2012 Pearson Education, Inc.  Metabolic Functions of the Liver Glycogenesis—“glycogen formation” Glucose molecules are converted to glycogen Glycogen molecules are stored in the liver Glycogenolysis—“glucose splitting” Glucose is released from the liver after conversion from glycogen Gluconeogenesis—“formation of new sugar” Glucose is produced from fats and proteins © 2012 Pearson Education, Inc.  Glycogenesis: Glucose converted to glycogen and stored IMB ALA Stimulus: NC Rising blood E glucose level HOMEOSTATIC BLOOD SUGAR Stimulus: IMB Falling blood ALA NC glucose level E Glycogenolysis: Stored glycogen converted to glucose Gluconeogenesis: Amino acids and fats © 2012 Pearson Education, Inc. converted to glucose Figure 14.23  Metabolic Functions of the Liver Fats and fatty acids are picked up by the liver Some are oxidized to provide energy for liver cells The rest are broken down into simpler compounds and released into the blood © 2012 Pearson Education, Inc.  Cholesterol Metabolism Cholesterol is not used to make ATP Functions of cholesterol Serves as a structural basis of steroid hormones and vitamin D Is a major building block of plasma membranes Most cholesterol is produced in the liver (85 percent) and is not from diet (15 percent) © 2012 Pearson Education, Inc.  Cholesterol Transport Cholesterol and fatty acids cannot freely circulate in the bloodstream They are transported by lipoproteins (lipid-protein complexes) Low-density lipoproteins (LDLs) transport to body cells Rated “bad lipoproteins” since they can lead to artherosclerosis High-density lipoproteins (HDLs) transport from body cells to the liver © 2012 Pearson Education, Inc.  Body Energy Balance Energy intake = total energy output (heat + work + energy storage) Energy intake is the energy liberated during food oxidation Energy produced during glycolysis, Krebs cycle and the electron transport chain Energy output Energy we lose as heat (60 percent) Energy stored as fat or glycogen © 2012 Pearson Education, Inc.  Regulation of Food Intake Body weight is usually relatively stable Energy intake and output remain about equal Mechanisms that may regulate food intake Levels of nutrients in the blood Hormones Body temperature Psychological factors © 2012 Pearson Education, Inc.  Metabolic Rate and Body Heat Production Basic metabolic rate (BMR)—amount of heat produced by the body per unit of time at rest Average BMR is about 60 to 72 kcal/hour Kilocalorie (kcal) is the unit of measure for the energy value of foods and the amount of energy used by the body © 2012 Pearson Education, Inc.  Metabolic Rate and Body Heat Production Factors that influence BMR Surface area—a small body usually has a higher BMR Gender—males tend to have higher BMRs Age—children and adolescents have higher BMRs The amount of thyroxine produced is the most important control factor More thyroxine means a higher metabolic rate © 2012 Pearson Education, Inc.  Total Metabolic Rate (TMR) TMR = Total amount of kilocalories the body must consume to fuel ongoing activities TMR increases with an increase in body activity TMR must equal calories consumed to maintain homeostasis and maintain a constant weight © 2012 Pearson Education, Inc.  Body Temperature Regulation Most energy is released as foods are oxidized Most energy escapes as heat © 2012 Pearson Education, Inc.  Body Temperature Regulation The body has a narrow range of homeostatic temperature Must remain between 35.6°C to 37.8°C (96°F to 100°F) The body’s thermostat is in the hypothalamus Initiates heat-loss or heat-promoting mechanisms © 2012 Pearson Education, Inc.  Body Temperature Regulation Heat-promoting mechanisms Vasoconstriction of blood vessels Blood is rerouted to deeper, more vital body organs Shivering—contraction of muscles produces heat © 2012 Pearson Education, Inc.  Body Temperature Regulation Heat-loss mechanisms Heat loss from the skin via radiation and evaporation Skin blood vessels and capillaries are flushed with warm blood Evaporation of perspiration cools the skin © 2012 Pearson Education, Inc.  Skin blood vessels dilate: Capillaries become flushed with warm blood; heat radiates from skin surface Activates heat-loss center in hypothalamus Sweat glands activated: Body temperature Secrete perspiration, which decreases: Blood Blood warmer is vaporized by body heat, temperature than hypothalamic helping to cool the body declines and set point hypothalamus heat-loss center “shuts off” Stimulus: Increased body IMB ALA temperature NC E (e.g., when exercising or the HOMEOSTASIS = normal body temperature climate is hot) (35.6°C–37.8°C) Stimulus: Decreased body temperature IMB (e.g., due to cold ALA NC environmental E temperatures) Skin blood vessels constrict: Blood is diverted from skin Blood cooler than capillaries and withdrawn to hypothalamic set Body temperature deeper tissues; minimizes point increases: Blood overall heat loss from temperature rises skin surface and hypothalamus heat-promoting center “shuts off” Activates heat- promoting center in hypothalamus Skeletal muscles activated when more heat must be generated; © 2012 Pearson Education, Inc. shivering begins Figure 14.24  Stimulus: Increased body IMB ALA temperature NC E (e.g., when exercising or the HOMEOSTASIS = normal body temperature climate is hot) (35.6°C–37.8°C) IMB ALA NCE © 2012 Pearson Education, Inc. Figure 14.24, step 1  Activates heat-loss center in hypothalamus Blood warmer than hypothalamic set point Stimulus: Increased body IMB ALA temperature NC E (e.g., when exercising or the HOMEOSTASIS = normal body temperature climate is hot) (35.6°C–37.8°C) IMB ALA © 2012 Pearson Education, Inc. NCE Figure 14.24, step 2  Skin blood vessels dilate: Capillaries become flushed with warm blood; heat radiates from skin surface Activates heat-loss center in hypothalamus Sweat glands activated: Secrete perspiration, which Blood warmer is vaporized by body heat, than hypothalamic helping to cool the body set point Stimulus: Increased body IMB ALA temperature NC E (e.g., when exercising or the HOMEOSTASIS = normal body temperature climate is hot) (35.6°C–37.8°C) IMB ALA © 2012 Pearson Education, Inc. NCE Figure 14.24, step 3  Skin blood vessels dilate: Capillaries become flushed with warm blood; heat radiates from skin surface Activates heat-loss center in hypothalamus Sweat glands activated: Body temperature Secrete perspiration, which decreases: Blood Blood warmer is vaporized by body heat, temperature than hypothalamic helping to cool the body declines and set point hypothalamus heat-loss center “shuts off” Stimulus: Increased body IMB ALA temperature NC E (e.g., when exercising or the HOMEOSTASIS = normal body temperature climate is hot) (35.6°C–37.8°C) IMB ALA © 2012 Pearson Education, Inc. N CE Figure 14.24, step 4  Skin blood vessels dilate: Capillaries become flushed with warm blood; heat radiates from skin surface Activates heat-loss center in hypothalamus Sweat glands activated: Body temperature Secrete perspiration, which decreases: Blood Blood warmer is vaporized by body heat, temperature than hypothalamic helping to cool the body declines and set point hypothalamus heat-loss center