Lecture 6: Blood Components PDF

Blood is liquid CT which circulates in CVS.toplam volume is 6L.It consist of C & ECSorICS>it is considered the basic S which is called plasma.it gives B liquid Ppty.Cs are called shaped element of B.It include RCB,WBC,P is straw Y in C.45%C,55%P.Fu:transport DF to Tissue,mebolites & En, wasteM to ki...

Blood is liquid CT which circulates in CVS.toplam volume is 6L.It consist of C & ECSorICS>it is considered the basic S which is called plasma.it gives B liquid Ppty.Cs are called shaped element of B.It include RCB,WBC,P is straw Y in C.45%C,55%P.Fu:transport DF to Tissue,mebolites & En, wasteM to kidney,O& CO2 to Tiss & organs,H from SE plac to target organ.homeostasis of B temp,B PH.Protection fro ForeignS.Serum:has clotting ability,Fbgen to Fbrin when exp to air,Y sticky L is S.Best Method to see C in BisBsmear RCB:carry O & CO2 b/w lungs & Tiss.lifespan is 100- 120Ds. Need inc when at high altitude/B needs more O & decr in anemia.Hemoglobin:gives B red C.it binds to O & carry to Tiss.it has iron containing hem grop,4 globin Ppchains A,B, D,G.HG hbA>2A & 2B,HG hbA2> 2A & 2D,HG hbF>2A & 2G defects in Hgchains cause sickle cell disease.WBC:Body Df. Inc in WBC is leukocytosis.dec in WBC is leukopenia.can be pass from B to tiss.they are divided by presense of gran ules.Agranulocytes do not have granules in CP while GC have granules in CP.Nucleus of AGC consist of single piece. N of GC have serval pieces.GC lack ability of dividing.Neutr ophil:most common GC & WBC60-70%.also called poly morphs because of multi-nuclei.have 3 type of G specific, azurophilic,tertiary Granules.motile cells enter the damge tiss first and play a role in inflammation & wound healing. Eosinophil:1-3%WBC,nuclei is bilobed,have specific G.they work in allergic & parasitic disease.Basophil:0.5WBC, involed in inflammation & preventing B clotting.lymphoCs are functional unit of immune or lymphatic sys.they take part in defence sys.3 type>T-L80% have long life span,B-L responsible for producing circulating antibodies,Nkill C programmed to kill certain C with viruse.Moncyte:largest WBC in B.From B marrow they travel to B for 3 days then go to B tiss where they differeniate into phagocytes of different type.when they encounter harmfull substances they become activate & turn into macrophages.Platlets:L span is 10Ds.they are small,M-bounded.glycocalyx layer At outermost m of P allow them to adhere to each other and go to bleeding area.4 zones>peripheral zone:outermo Structural zone:consist of network that supports the PM includes MT,AF etc.Organelle zone:cover the center of platelet having MC,peroxiosomes.Membrane zone:2 chan nels,open canalicular sys>recesses of PM towards CP & dense tubular sys>storage area for calcium ion.A plug or a thrombus is formed at injury site to stop bleeding,also hav En to repair injury & enable blood clotting.Hematopoiesis: is process by which mature BC are develop from precursor C & organ which produce BC are called hemopoietic organ BC are produced from mesoderm,from liver & spleen,B Marrow at later stage.All BC are developed from 1 cell in BM called pluripotent stem cells.