Hematological Disorders Lecture 2 PDF
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Nova Southeastern University
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Summary
This document discusses hematological disorders, focusing on laboratory abnormalities associated with vitamin B12 deficiency, including macrocytic anemia, low reticulocyte count, and low serum vitamin B12 levels. It also touches on serum ferritin, iron binding capacity, and other related topics.
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Serum Ferritin Measure of iron storage Total Iron Binding Capacity (TIBC) Measure of transferrin Binds to iron in the blood Serum Iron Canadian Medical Association Journal Possible Laboratory Abnormalities in B12 Deficiency Macrocytic anemia Normocytic anemia with increased...
Serum Ferritin Measure of iron storage Total Iron Binding Capacity (TIBC) Measure of transferrin Binds to iron in the blood Serum Iron Canadian Medical Association Journal Possible Laboratory Abnormalities in B12 Deficiency Macrocytic anemia Normocytic anemia with increased red cell distribution width if iron deficiency present Low reticulocyte count Leukopenia and/or thrombocytopenia (mild) Hypersegmented neutrophils on blood smear Low serum vitamin B12 level Elevated serum homocysteine and methylmalonic acid Anti-intrinsic factor antibodies if autoimmune pernicious anemia present Pancytopenia (decrease in all types of cells) Courtesy of Understand Hematology Salmon Patch Black Sunbursts Iridescent Spots of Hemosiderin Silver Wiring Courtesy of the National Cancer Institute Courtesy of American Journal of Ophthalmology Courtesy of Mayo Clinic Proceedings
