Kidd Blood Group System PDF

Kidd Blood Group System Kidd Blood Group System Symbols: Jka, Jkb Antibodies are clinically significant IgG 37°C AHG phase Treating antigens on rbcs with enzymes enhances the agglutination with antibodies Kidd System cont… Jka – Kidd a Jkb- Kidd b Kidd antibodies are often...

Kidd Blood Group System Kidd Blood Group System Symbols: Jka, Jkb Antibodies are clinically significant IgG 37°C AHG phase Treating antigens on rbcs with enzymes enhances the agglutination with antibodies Kidd System cont… Jka – Kidd a Jkb- Kidd b Kidd antibodies are often linked to extravascular hemolysis in delayed hemolytic transfusion reactions Kidd antigens develop early on fetal rbcs Not extremely immunogenic Genetics of Kidd system Located on chromosome 18 1 locus: alleles are Jka, Jkb, Jk Jka and Jkb are codominant Jk is a silent allele, common in Polynesian, Filipino, and Chinese populations: Jk(a-b-) phenotype Kidd Antibodies Clinically significant React weakly in vitro but can cause severe transfusion reactions in vivo Associated with delayed hemolytic transfusion reactions and extravascular hemolysis Capable of activation and binding of complement causing intravascular hemolysis as well Kidd Antibodies cont… IgG Observed in IAT Dosage Bind complement Produced in response to transfusion or pregnancy Usually appear in combination with other antibodies from other systems Detection of these antibodies is enhanced with enzymes, LISS, PEG Antibodies do not store well, ab concentration decreases quickly in vivo