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## Renal System & Conditions PLP PT/OT Board Review by Paul Jimson Sy, PTRP ### Tubuloglomerular Feedback | ↑ NaCl Concentration | ↑ NaCl Concentration | |---|---| | macula densa detects NaCl concentration | Release nitric oxide | | Release Adenosine | AA dilates | | AA Constrict | | ### II. R...

## Renal System & Conditions PLP PT/OT Board Review by Paul Jimson Sy, PTRP ### Tubuloglomerular Feedback | ↑ NaCl Concentration | ↑ NaCl Concentration | |---|---| | macula densa detects NaCl concentration | Release nitric oxide | | Release Adenosine | AA dilates | | AA Constrict | | ### II. Reabsorption - removal of substances or H2O from the luminal fluid into the body #### **PCT** - most reabsorption - H2O, Na (40%) - other substances: amino acid, glucose, electrolytes (Mg, Ca, K) - (+) Na-K ATPase pump #### Loop of Henle | Thin Descending | Thin Ascending | Thick Ascending | |---|---|---| | H2O is permeable d/t | H2O **is not** permeable | medullary Thickening Segment | | Aquaporin-1 channels | Na reabsorption | H2O **is not** permeable | | Most concentrated luminal fluid (laman of renal tubules) | | 2nd most Na reabsorption | | | | Mg must reabsorb | | | | others: Ca, K | #### Early DCT - H2O is not permeable - (+) Ncc - Na-a Cotransporter - Site of activation: PTH (parathyroid hormone) - Stimulates Ca reabsorption #### Late DCT & Collecting Tubules - Principal cells - Na reabsorption - ADH-induced H2O reabsorption - Intercalated cells: reabsorption - Type A: HCO3, K - Type B: Cl, H ### III. Secretion - removal or transfer of substances (esp. wastes) from the body / tubular cells into the luminal fluid **Outcomes:** - Regulate urine output - Excrete metabolic waste **Renal System and Conditions Lecture Handouts** by Paul Jimson Sy, PTRP, for the Premium Learning Program PT/OT Board Exam. Unauthorized reproduction, use or dissemination, uploading or downloading is strictly prohibited and shall be prosecuted to the full extent of the law, including administrative complaints with the Professional Regulatory Board, Philippine Regulation Commission.