Complement Pathways PDF

Ok, here are the transcriptions of the images you sent: **Image 1** The image is a diagram illustrating the Lectin Pathway. ### LECTIN PATHWAY #### Components and Steps: 1. A microbe with carbohydrate-containing mannan is shown. 2. Components include C1-like complex, C4, C2, and C3. 3. **Reac...

Ok, here are the transcriptions of the images you sent: **Image 1** The image is a diagram illustrating the Lectin Pathway. ### LECTIN PATHWAY #### Components and Steps: 1. A microbe with carbohydrate-containing mannan is shown. 2. Components include C1-like complex, C4, C2, and C3. 3. **Reactions**: * $C4 \rightarrow C4a + C4b$ * $C2 \rightarrow C2b + C2a$ * $C4b + C2a \rightarrow C4b2a$ (C3-Convertase) * $C3 \rightarrow C3a + C3b$ (C3 convertase) * $C4b2a + C3b \rightarrow C4b2a3b$ (C5-Convertase) * $C5 \rightarrow C5b + C5a$ **Image 2** The image is a diagram illustrating the classical pathway. **Classical Pathway** #### Components and Steps: 1. Antigen-Antibody (AG AB) complex interacting with a microbe. 2. Components include C1qrs, C4, C2, C3, C5, C6, C7, and C8. * **Reactions**: * $C4 \rightarrow C4a + C4b$ * $C2 \rightarrow C2b + C2a$ * $C4b + C2a \rightarrow C4b2a$ (C3-Convertase) * $C3 \rightarrow C3a + C3b$ (C3 convertase) * $C4b2a + C3b \rightarrow C4b2a3b$ (C5-Convertase) * $C5 \rightarrow C5a + C5b$ * $C5b + C6 + C7 \rightarrow C5b67$, which then inserts into the pathogen cell membrane. **Image 3** The image is a diagram illustrating the alternative pathway. ### Alternative Pathway #### Components and Steps: 1. Factors B and D, Properdin. 2. $C3 + H_2O$. * **Reactions**: * $C3 \rightarrow C3(H_2O)$ * $C3(H_2O) + Bb \rightarrow C3(H_2O)Bb$ (Fluid phase C3 convertase) * C3 convertase $C3 \rightarrow C3a + C3b$ * $C3b + Bb \rightarrow C3bBb$ * $C3bBb \xrightarrow{Properdin} C3bBb3b$ (C5-Convertase) * $C5 \rightarrow C5a + C5b$ * $C5b \xrightarrow{C6, C7, C8}, Target Pathogen Membrane$