Drugs of Choice/Active Drugs for Specific Pathogens PDF

RxPrep Course Book | RxPrep © 2019, RxPrep © 2020 SUMMARY TABLES DRUGS OF CHOICE /ACTIVE DRUGS FOR SPECIFIC PATHOGENS Community-associated methicillinresistant Staphylococcus aureus (CA MRSA ) skin & soft tissue infections (SSTIs) SMX/ TMP Doxycycline, minocycline Clindamycin* Linezolid VRE (E....

RxPrep Course Book | RxPrep © 2019, RxPrep © 2020 SUMMARY TABLES DRUGS OF CHOICE /ACTIVE DRUGS FOR SPECIFIC PATHOGENS Community-associated methicillinresistant Staphylococcus aureus (CA MRSA ) skin & soft tissue infections (SSTIs) SMX/ TMP Doxycycline, minocycline Clindamycin* Linezolid VRE (E. faecium) Daptomycin Carbapenem-resistant Gram-negative rods (CRE) Linezolid Ceftazidime/Avibactam Quinupristin/ Dalfopristin Colistimethate, polymyxin B Tigecycline Cystitis only: nitrofurantoin, fosfomycin, doxycycline Bacteroides fragilis Metronidazole Beta- lactam /beta-lactamase inhibitor For more severe SSTIs requiring IV treatment or hospitalization (cover MRSA and Streptococci ) Vancomycin (consider using alternative if MIC 2 ) Linezolid, tedizolid Ceftazidime/Avibactam Cefepime Tigecycline Ceftazidime Others (reduced activity): clindamycin, moxifloxacin Daptomycin Ceftolozane/Tazobactam Ceftaroline Carbapenems (except ertapenem) Telavancin Ciprofloxacin, levofloxacin Oritavancin Aztreonam Dalbavancin Aminoglycosides Quinupristin/ Dalfopristin Colistimethate, polymyxin B Tigecycline Acinetobacter baumannii Nosocomial MRSA Vancomycin (consider using alternative if MIC > 2) Linezolid Daptomycin (not in pneumonia) Rifampin (select infections, never used alone) Telavancin VRE (E. faecalis ) Pen G or ampicillin Linezolid Daptomycin Carbapenems C. difficile Infection Vancomycin (oral) Fidaxomicin Metronidazole Atypical Organisms Azithromycin, clarithromycin Carbapenems (except ertapenem) Doxycycline, minocycline Ampicillin/ Sulbactam Quinolones Minocycline HNPEK Beta- lactam / beta- lactamase inhibitor Tigecycline Quinolones SMX/ TMP Amoxicillin (if beta-lactamase negative) . Colistimethate polymyxin B Extended spectrum beta- lactamase producing Gram-negative rods (ESBL GNR) - E. coli , K . pneumoniae , P. mirabilis Carbapenems Tigecycline Ceftolozane/Tazobactam Cystitis only: nitrofurantoin, fosfomycin, Ceftazidime/Avibactam doxycycline . Pseudomonas aeruginosa Piperacillin/Tazobactam Cefotetan cefoxitin Cephalosporins (except 1st generation) Carbapenems SMX/ TMP Aminoglycosides Quinolones Cefepime (high - dose) Aminoglycosides Cystitis only: fosfomycin 'A D-tcst must be performed before using clindamycin. n /n