Antimicrobial Therapy
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Antimicrobial Therapy

Test your knowledge of drugs of choice and active drugs for specific pathogens with this RxPrep summary tables quiz. Identify the most effective treatment options for community-associated MRSA, VRE, and carbapenem-resistant Gram-negative rods, among others. Sharpen your understanding of antimicrobial therapy with this comprehensive quiz.

Created by
@FerventWalrus

Questions and Answers

Which antibiotic is recommended for treating Clostridioides difficile infection?

Vancomycin (oral)

Which antibiotic is effective against Atypical Organisms such as Mycoplasma pneumoniae?

Azithromycin

Which antibiotic is suitable for treating infections caused by Pseudomonas aeruginosa?

Piperacillin/Tazobactam

Which antibiotic is a drug of choice for Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin & soft tissue infections (SSTIs)?

<p>Doxycycline</p> Signup and view all the answers

Which antibiotic is recommended for treating Vancomycin-resistant Enterococcus (VRE) infections?

<p>Daptomycin</p> Signup and view all the answers

What is the drug of choice for Acinetobacter baumannii infections?

<p>Linezolid</p> Signup and view all the answers

Which antibiotic is recommended for treating Bacteroides fragilis infections?

<p>Metronidazole</p> Signup and view all the answers

Name three antibiotics recommended for treating Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin & soft tissue infections (SSTIs).

<p>SMX/TMP, Doxycycline, Clindamycin</p> Signup and view all the answers

What is the drug of choice for treating Vancomycin-resistant Enterococcus (VRE) infections?

<p>Daptomycin</p> Signup and view all the answers

Which antibiotic is recommended for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci?

<p>Vancomycin</p> Signup and view all the answers

Name an antibiotic effective against Nosocomial MRSA.

<p>Linezolid</p> Signup and view all the answers

Which antibiotic is recommended for treating Clostridioides difficile infection?

<p>Vancomycin (oral), Fidaxomicin, Metronidazole</p> Signup and view all the answers

What antibiotics are effective against Atypical Organisms such as Mycoplasma pneumoniae?

<p>Azithromycin, clarithromycin</p> Signup and view all the answers

What antibiotics are suitable for treating infections caused by Pseudomonas aeruginosa?

<p>Piperacillin/Tazobactam, Ceftolozane/Tazobactam, Cefepime (high-dose), Aminoglycosides</p> Signup and view all the answers

Match the following antibiotics with their primary usage:

<p>Vancomycin (oral) = Clostridioides difficile Infection Fidaxomicin = Clostridioides difficile Infection Metronidazole = Clostridioides difficile Infection Azithromycin, clarithromycin = Atypical Organisms</p> Signup and view all the answers

Match the following antibiotics with the bacteria they are effective against:

<p>Ampicillin/ Sulbactam = Extended spectrum beta-lactamase producing Gram-negative rods (ESBL GNR) - E. coli, K. pneumoniae, P. mirabilis Ceftolozane/Tazobactam = Pseudomonas aeruginosa Cefepime (high-dose) = Pseudomonas aeruginosa Piperacillin/Tazobactam = Pseudomonas aeruginosa</p> Signup and view all the answers

Match the following antibiotics with the type of infection they are suitable for treating:

<p>Ceftazidime/Avibactam = Cystitis only nitrofurantoin, fosfomycin = Cystitis only Colistimethate polymyxin B = Cystitis only Cystitis only: fosfomycin = Cystitis only</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin & soft tissue infections (SSTIs):

<p>SMX/TMP = Recommended Daptomycin = Not recommended Ceftolozane/Tazobactam = Not recommended Linezolid = Recommended</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Vancomycin-resistant Enterococcus (VRE) infections:

<p>Ceftazidime/Avibactam = Not recommended Daptomycin = Recommended Colistimethate, polymyxin B = Recommended Vancomycin = Not recommended</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Carbapenem-resistant Gram-negative rods (CRE):

<p>Linezolid = Not recommended Ceftazidime/Avibactam = Recommended Tigecycline = Recommended Quinupristin/Dalfopristin = Not recommended</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Acinetobacter baumannii infections:

<p>Rifampin = Recommended Telavancin = Recommended Ceftolozane/Tazobactam = Not recommended Vancomycin = Not recommended</p> Signup and view all the answers

Which antibiotic is recommended for treating Clostridioides difficile infection?

<p>Vancomycin (oral)</p> Signup and view all the answers

Which antibiotic is effective against Atypical Organisms such as Mycoplasma pneumoniae?

<p>Doxycycline</p> Signup and view all the answers

Which antibiotic is recommended for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci?

<p>Cefepime (high-dose)</p> Signup and view all the answers

Which antibiotic is recommended for treating Clostridioides difficile infection?

<p>Vancomycin</p> Signup and view all the answers

What is the drug of choice for Acinetobacter baumannii infections?

<p>Colistimethate</p> Signup and view all the answers

Which antibiotic is effective against Atypical Organisms such as Mycoplasma pneumoniae?

<p>Doxycycline</p> Signup and view all the answers

What antibiotics are suitable for treating infections caused by Pseudomonas aeruginosa?

<p>Ceftolozane/Tazobactam</p> Signup and view all the answers

Which antibiotics are recommended for treating Clostridioides difficile infection?

<p>Vancomycin (oral), Fidaxomicin, Metronidazole</p> Signup and view all the answers

Name three antibiotics effective against Pseudomonas aeruginosa infections.

<p>Piperacillin/Tazobactam, Ceftolozane/Tazobactam, Carbapenems</p> Signup and view all the answers

What antibiotics are suitable for treating Extended Spectrum Beta-lactamase producing Gram-negative rods (ESBL GNR) infections?

<p>Carbapenems, Tigecycline, Ceftolozane/Tazobactam</p> Signup and view all the answers

Which antibiotics are recommended for treating Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin & soft tissue infections (SSTIs)?

<p>SMX/TMP, Doxycycline, Minocycline, Clindamycin, Linezolid</p> Signup and view all the answers

What are the drug options for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci?

<p>Vancomycin, Linezolid, Tedizolid, Ceftazidime/Avibactam, Cefepime, Tigecycline, Ceftazidime, Clindamycin, Moxifloxacin, Daptomycin, Ceftolozane/Tazobactam, Ceftaroline, Carbapenems, Telavancin, Ciprofloxacin, Levofloxacin, Oritavancin, Aztreonam, Dalbavancin, Aminoglycosides, Quinupristin/Dalfopristin, Colistimethate, Polymyxin B, Tigecycline</p> Signup and view all the answers

What antibiotics are recommended for treating Vancomycin-resistant Enterococcus (VRE) infections?

<p>Daptomycin, Linezolid, Pen G, Ampicillin, Carbapenems</p> Signup and view all the answers

Which antibiotics are effective against Acinetobacter baumannii infections?

<p>Vancomycin, Linezolid, Daptomycin, Rifampin, Telavancin, Carbapenems</p> Signup and view all the answers

Match the following antibiotics with the bacteria they are effective against:

<p>Vancomycin (oral) = Clostridioides difficile Ceftolozane/Tazobactam = Pseudomonas aeruginosa Fidaxomicin = Clostridioides difficile Tigecycline = Extended spectrum beta-lactamase producing Gram-negative rods (ESBL GNR)</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Acinetobacter baumannii infections:

<p>Carbapenems = Effective Aminoglycosides = Effective Colistimethate polymyxin B = Effective Quinolones = Ineffective</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Extended Spectrum Beta-lactamase producing Gram-negative rods (ESBL GNR) infections:

<p>Carbapenems = Effective Cefepime (high-dose) = Effective Quinolones = Ineffective Ampicillin/Sulbactam = Ineffective</p> Signup and view all the answers

Is daptomycin recommended for treating Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin & soft tissue infections (SSTIs)?

<p>True</p> Signup and view all the answers

Is nitrofurantoin suitable for treating cystitis caused by Carbapenem-resistant Gram-negative rods (CRE)?

<p>False</p> Signup and view all the answers

Is rifampin recommended for treating Nosocomial MRSA?

<p>True</p> Signup and view all the answers

Is vancomycin recommended for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci?

<p>True</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci:

<p>Vancomycin = Consider using alternative if MIC &gt; 2 Linezolid = Tedizolid Ceftazidime/Avibactam = Cefepime Tigecycline = Ceftazidime</p> Signup and view all the answers

Match the following antibiotics with the bacteria they are effective against:

<p>SMX/TMP = Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) Daptomycin = VRE (E. faecium) Ceftazidime/Avibactam = Carbapenem-resistant Gram-negative rods (CRE) Colistimethate, polymyxin B = Acinetobacter baumannii</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Cystitis only:

<p>Nitrofurantoin = Fosfomycin Doxycycline = Minocycline Clindamycin = Linezolid Tigecycline = Ceftazidime</p> Signup and view all the answers

Match the following antibiotics with their recommended usage for Nosocomial MRSA:

<p>Vancomycin = Consider using alternative if MIC &gt; 2 Linezolid = Daptomycin (not in pneumonia) Rifampin = Telavancin Colistimethate, polymyxin B = Tigecycline</p> Signup and view all the answers

Match the antibiotic with the bacteria it is effective against:

<p>Linezolid = VRE (E. faecium) Daptomycin = Nosocomial MRSA Tigecycline = Acinetobacter baumannii Vancomycin = Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA)</p> Signup and view all the answers

Match the antibiotic with its recommended usage for more severe SSTIs requiring IV treatment or hospitalization, covering MRSA and Streptococci:

<p>Vancomycin = Cover MRSA and Streptococci Linezolid = Cover MRSA and Streptococci Ceftazidime = Cover MRSA and Streptococci Tigecycline = Cover MRSA and Streptococci</p> Signup and view all the answers

Match the antibiotic with the type of infection it is suitable for treating:

<p>SMX/TMP = Community-associated methicillin-resistant Staphylococcus aureus (CA MRSA) skin &amp; soft tissue infections (SSTIs) Doxycycline = Cystitis only Clindamycin = More severe SSTIs requiring IV treatment or hospitalization Nitrofurantoin = Cystitis only</p> Signup and view all the answers

Match the antibiotic with its recommended usage for Vancomycin-resistant Enterococcus (VRE) infections:

<p>Daptomycin = E. faecalis Linezolid = E. faecalis Carbapenems = E. faecalis Pen G or ampicillin = E. faecalis</p> Signup and view all the answers

Vancomycin is recommended for treating Clostridioides difficile infection?

<p>False</p> Signup and view all the answers

Doxycycline is effective against Atypical Organisms such as Mycoplasma pneumoniae?

<p>True</p> Signup and view all the answers

Tigecycline is suitable for treating Cystitis only?

<p>False</p> Signup and view all the answers

Vancomycin is the drug of choice for treating Clostridioides difficile infection

<p>True</p> Signup and view all the answers

Tigecycline is recommended for treating Carbapenem-resistant Gram-negative rods (CRE) infections

<p>True</p> Signup and view all the answers

Azithromycin and clarithromycin are effective against Atypical Organisms such as Mycoplasma pneumoniae

<p>True</p> Signup and view all the answers

Study Notes

Community-Associated Methicillin-Resistant Staphylococcus aureus (CA MRSA)

  • CA MRSA skin and soft tissue infections (SSTIs):
    • Treatment options: SMX/TMP, doxycycline, minocycline, clindamycin*, linezolid
  • More severe SSTIs requiring IV treatment or hospitalization:
    • Cover MRSA and Streptococci with:
      • Vancomycin (consider alternative if MIC > 2)
      • Linezolid, tedizolid
      • Ceftazidime/Avibactam
      • Cefepime
      • Tigecycline

Vancomycin-Resistant Enterococcus (VRE)

  • VRE (E. faecium):
    • Treatment options: daptomycin, carbapenems
  • VRE (E. faecalis):
    • Treatment options: penicillin G or ampicillin, linezolid, daptomycin, carbapenems

Carbapenem-Resistant Gram-Negative Rods (CRE)

  • CRE:
    • Treatment options: linezolid, ceftazidime/Avibactam, quinupristin/dalfopristin, colistimethate, polymyxin B, tigecycline

Bacteroides fragilis

  • Treatment options: metronidazole, beta-lactam/beta-lactamase inhibitor

Extended Spectrum Beta-Lactamase (ESBL) Producing Gram-Negative Rods (ESBL GNR)

  • ESBL GNR (E. coli, K. pneumoniae, P. mirabilis):
    • Treatment options: carbapenems, tigecycline, ceftolozane/Tazobactam
    • Cystitis only: nitrofurantoin, fosfomycin, doxycycline

Pseudomonas aeruginosa

  • Treatment options: piperacillin/Tazobactam, cefotetan, cefoxitin, cephalosporins (except 1st generation), carbapenems, SMX/TMP, aminoglycosides, quinolones, cefepime (high dose)

Clostridium difficile Infection

  • Treatment options: vancomycin (oral), fidaxomicin, metronidazole

Atypical Organisms

  • Treatment options: azithromycin, clarithromycin, carbapenems (except ertapenem), doxycycline, minocycline, ampicillin/sulbactam, quinolones, minocycline, HNPEK, beta-lactam/beta-lactamase inhibitor, tigecycline, quinolones, SMX/TMP

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