HMP Shunt 2024 PDF
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Summary
This document discusses the HMP shunt, focusing on Favism, a genetic deficiency of glucose-6-phosphate dehydrogenase. It covers precipitating factors like certain drugs and fava beans, symptoms, and the mechanism.
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Favism Genetic deficiency of glucose-6-phosphate dehydrogenase (G6PD). Precipitating factors: Certain drugs (premaquine, aspirin or sulfonamides) Fava beans (containing divicine and other oxidants). Symptoms: Asymptomatic: in between attacks. Hemolytic crisis: on ex...
Favism Genetic deficiency of glucose-6-phosphate dehydrogenase (G6PD). Precipitating factors: Certain drugs (premaquine, aspirin or sulfonamides) Fava beans (containing divicine and other oxidants). Symptoms: Asymptomatic: in between attacks. Hemolytic crisis: on exposure to above factors. Mechanism: G6PD deficiency HMP inhibition NADPH Inhibition of glutathione reductase reduced glutathione failure to protect cells from oxidative damage by H2O2 Lysis of red cells hemolytic anemia Regulation of Pentose Phosphate Pathway Allosteric regulation: NADPH is a strong inhibitor of G6PD. Hormonal regulation: Insulin induces synthesis of G6PD (key enzyme of HMP).
