haem+cells+presentation1.pdf

Key cells: red cells, white cell and platelets…and how we examine them Dr Richard Gooding Haematology consultant Aim To appreciate the rich diversity of the function of each of the major types of blood cell and how their function is related to their structure and physi...

Key cells: red cells, white cell and platelets…and how we examine them Dr Richard Gooding Haematology consultant Aim To appreciate the rich diversity of the function of each of the major types of blood cell and how their function is related to their structure and physiology Learning outcomes To be able to describe the developmental sequence of erythroid cells and the derivation of the red cell indices To describe the morphology and function of the various types of white cells Loading… To describe the morphology and function of platelets To explain the basic principle of haematology analysers Haematology family tree Early red cells (BM) overtime chromatin Condenses · these cells shouldn't be in peripheral blood. Loading… Normal red cells (PB) · Purple dots = platelets Myeloid differentiation (red and white) eosinophils or -or Basophils Y Neutrophils (PB) Loading… Eosinophils (PB) bilobed E o Basophils (PB) Monocytes (PB)  Lymphocytes small microcytic? Lymphoid-active-chromati - s lymphocyte  leukaemia-lots of · chronic lymphocytic slide mature lymphocytes (fragile)break on formation of smear cells  CD markers - cluster of differentiation clusters ·to differentiate of cells from eachother · All cells have receptors with potential to be target LABELLING Platelets (PB) & Megakaryocytes (BM) Loading…  Platelet functions · Early clot formation Testing Haematology analysers · counts number of times laser affected by material =number of cells · sample-blood from patient put in coagulant to prevent clotting Bone marrow test Seine, Sternum - , hins (Pelvis) Bone marrow morphology & other tests Other tests Bone marrow: Surface markers Karyotype analysis Molecular genetics/mutation testing Other cells Platelet function Learning outcomes To be able to describe the developmental sequence of erythroid cells and the derivation of the red cell indices To describe the morphology and function of the various types of white cells To describe the morphology and function of platelets To explain the basic principle of haematology analysers