Glycogenolysis PDF
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This document explains the process of glycogenolysis, the breakdown of glycogen into glucose. It details the enzymes involved and the steps involved in the process. The article discusses Glycogen phosphorylase in the process.
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Glycogenolysis - breaking down stored glycogen stores into glucose Firstly, glucogen is cleaved by the addition of orthophosphate (Pi), catalysed by Glycogen Phosphorylase Glycogen (n) +Pi ? Glucose 1-phosphate + Glycogen (n-1) Secondly, Glycogen 1-phosphorylase attacks the a-1,4 linakages until it...
Glycogenolysis - breaking down stored glycogen stores into glucose Firstly, glucogen is cleaved by the addition of orthophosphate (Pi), catalysed by Glycogen Phosphorylase Glycogen (n) +Pi ? Glucose 1-phosphate + Glycogen (n-1) Secondly, Glycogen 1-phosphorylase attacks the a-1,4 linakages until it reaches the a-1,6 linkages as it cannot prrocessess them. Debranching enzymes tranfers 3 glucosyl residues from the a-1,6 linkage to the a-1,4 linkage (main chain). The final molecule on the a-1,6 linkage is removed via hydrolysis using a-1,6 glucosidase Lastly, the glucose 1-phosphate is converted into glucose 6-phosphate by phosphoglucomutase. Glucose 6-phosphate can be directly metabolised. The phosphate from serine is transferred onto glucose 1-phosphate to make glucose 1,6-bisphosphate. The position 1 phosphate is then removed to give the final product of glucose 6-phosphate
