Glycogenolysis + regulation

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Questions and Answers

What is the enzyme responsible for adding orthophosphate to cleave glycogen?

  • Glycogen Phosphorylase (correct)
  • Glycogen 1-phosphorylase
  • Phosphoglucomutase
  • Debranching enzyme

Which enzyme is involved in attacking the a-1,4 linkages during glycogenolysis?

  • Glycogen 1-phosphorylase (correct)
  • Phosphoglucomutase
  • Glycogen Phosphorylase
  • Debranching enzyme

What is the role of debranching enzymes in glycogenolysis?

  • Cleaving glycogen with orthophosphate
  • Converting glucose 1-phosphate to glucose 6-phosphate
  • Transferring glucose residues from a-1,6 to a-1,4 linkages (correct)
  • Attacking a-1,4 linkages

What is the final product formed after the removal of the glucose molecule from the a-1,6 linkage?

<p>Glucose 1-phosphate (A)</p> Signup and view all the answers

Which enzyme is responsible for converting glucose 1-phosphate into glucose 6-phosphate?

<p>Phosphoglucomutase (A)</p> Signup and view all the answers

Explain the role of Glycogen Phosphorylase in glycogenolysis.

<p>Catalyzes the cleavage of glucose from glycogen by adding orthophosphate.</p> Signup and view all the answers

What is the function of Glycogen 1-Phosphorylase in glycogenolysis?

<p>Attacks the a-1,4 linkages in glycogen until it reaches the a-1,6 linkages.</p> Signup and view all the answers

Describe the mechanism of action of debranching enzymes in glycogenolysis.

<p>Transfers 3 glucosyl residues from the a-1,6 linkage to the a-1,4 linkage and hydrolyzes the final glucose molecule.</p> Signup and view all the answers

How does phosphoglucomutase participate in glycogenolysis?

<p>Converts glucose 1-phosphate into glucose 6-phosphate.</p> Signup and view all the answers

Explain the significance of glucose 6-phosphate in glycogenolysis.

<p>Can be directly metabolized and is an essential intermediate in glucose metabolism.</p> Signup and view all the answers

What enzyme in the liver is responsible for converting glucose 6-phosphate into glucose when needed by the body?

<p>Glucose 6-phosphatase</p> Signup and view all the answers

How is Glycogen broken down in muscles for anaerobic glycolysis?

<p>Glycogen phosphorylase</p> Signup and view all the answers

What activates phosphorylase b in muscles and inhibits phosphorylase a?

<p>AMP activates phosphorylase b, while ATP inhibits it.</p> Signup and view all the answers

Which hormone triggers the conversion of phosphorylase from its inactive form (b) to the active form (a)?

<p>Adrenaline/Epinephrine and glucagon</p> Signup and view all the answers

What is the role of Ca2+ in the regulation of glycogen breakdown in muscles?

<p>Ca2+ activates phosphorylase a, stimulating glycogen breakdown.</p> Signup and view all the answers

How is the signal for glycogen breakdown turned off in muscles?

<p>By dephosphorylating phosphorylase a to b.</p> Signup and view all the answers

What triggers the conversion of phosphorylase b to a in muscles?

<p>High Ca2+ levels (A)</p> Signup and view all the answers

Which subunit of phosphorylase kinase acts as the Ca2+ sensor?

<p>Delta (D)</p> Signup and view all the answers

What inhibits phosphorylase a in muscles?

<p>Low ATP (C)</p> Signup and view all the answers

Which hormone triggers the conversion of phosphorylase b to a?

<p>Epinephrine (C)</p> Signup and view all the answers

What role does protein phosphatase 1 play in glycogen breakdown regulation?

<p>Converts phosphorylase a to b (B)</p> Signup and view all the answers

In muscles, what activates phosphorylase kinase besides Ca2+?

<p>AMP (A)</p> Signup and view all the answers

What is the main factor that turns on phosphorylase b to a in muscles?

<p>Low ATP and High AMP levels (C)</p> Signup and view all the answers

What activates phosphorylase kinase by binding to the GPCR?

<p>Cyclic AMP (cAMP) (A)</p> Signup and view all the answers

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Related Documents

Glycogenolysis PDF
Glycogenolysis Regulation PDF

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