Drugs Used in Mood Disorders Part 6.docx

\#\#\# \*\*Slide 49: Bupropion Pharmacokinetics\*\* 1\. \*\*What is the primary enzyme responsible for the metabolism of bupropion?\*\* \- A. CYP3A4 \- B. CYP2D6 \- C. MAO-B \- D. CYP1A2 \*\*Answer:\*\* B. CYP2D6【67:0†source】 2\. \*\*Bupropion is contraindicated in patients with a history o...

\#\#\# \*\*Slide 49: Bupropion Pharmacokinetics\*\* 1\. \*\*What is the primary enzyme responsible for the metabolism of bupropion?\*\* \- A. CYP3A4 \- B. CYP2D6 \- C. MAO-B \- D. CYP1A2 \*\*Answer:\*\* B. CYP2D6【67:0†source】 2\. \*\*Bupropion is contraindicated in patients with a history of which condition?\*\* \- A. Hypertension \- B. Anxiety \- C. Seizure disorder \- D. Obesity \*\*Answer:\*\* C. Seizure disorder【67:0†source】 3\. \*\*In addition to its use in depression, bupropion is approved for which of the following conditions?\*\* \- A. Alcohol dependence \- B. Smoking cessation \- C. Migraine prevention \- D. ADHD \*\*Answer:\*\* B. Smoking cessation【67:0†source】 \-\-- \#\#\# \*\*Slide 50: New Medication: Dextromethorphan/Bupropion ER (Auvelity)\*\* 1\. \*\*What is the mechanism of action of dextromethorphan in Auvelity?\*\* \- A. NMDA receptor antagonist \- B. Serotonin reuptake inhibitor \- C. GABA receptor agonist \- D. Alpha-2 adrenergic antagonist \*\*Answer:\*\* A. NMDA receptor antagonist【67:0†source】 2\. \*\*What is a potential adverse reaction when combining dextromethorphan with other serotonergic medications?\*\* \- A. Serotonin syndrome \- B. Hypertensive crisis \- C. Bradycardia \- D. Respiratory depression \*\*Answer:\*\* A. Serotonin syndrome【67:0†source】 3\. \*\*How soon can symptom improvement begin after starting Auvelity for depression?\*\* \- A. 2 weeks \- B. 4 weeks \- C. 1 week \- D. 6 weeks \*\*Answer:\*\* C. 1 week【67:0†source】 \-\-- \#\#\# \*\*Slide 51: Trazodone (Desyrel)\*\* 1\. \*\*What receptor does trazodone antagonize that contributes to its sedative effects?\*\* \- A. Histamine H1 receptor \- B. Alpha-2 adrenergic receptor \- C. Serotonin 5-HT2A receptor \- D. GABA-A receptor \*\*Answer:\*\* A. Histamine H1 receptor【67:0†source】 2\. \*\*At low doses, trazodone is commonly used to treat which condition?\*\* \- A. Depression \- B. Anxiety \- C. Insomnia \- D. Bipolar disorder \*\*Answer:\*\* C. Insomnia【67:0†source】 3\. \*\*What is a rare but serious side effect associated with trazodone?\*\* \- A. Serotonin syndrome \- B. Priapism \- C. Hepatotoxicity \- D. Weight gain \*\*Answer:\*\* B. Priapism【67:0†source】 \-\-- \#\#\# \*\*Slide 52: Nefazodone\*\* 1\. \*\*Nefazodone is chemically related to which other antidepressant?\*\* \- A. Mirtazapine \- B. Trazodone \- C. Bupropion \- D. Sertraline \*\*Answer:\*\* B. Trazodone【67:0†source】 2\. \*\*What is a serious risk associated with nefazodone that has limited its use?\*\* \- A. Hepatotoxicity \- B. Seizures \- C. Hypertension \- D. Sexual dysfunction \*\*Answer:\*\* A. Hepatotoxicity【67:0†source】 3\. \*\*Nefazodone inhibits which enzyme, leading to significant drug interactions?\*\* \- A. CYP2D6 \- B. CYP3A4 \- C. MAO-B \- D. CYP1A2 \*\*Answer:\*\* B. CYP3A4【67:0†source】 \-\-- \#\#\# \*\*Slide 53: Mirtazapine (Remeron)\*\* 1\. \*\*What is the mechanism of action of mirtazapine?\*\* \- A. Serotonin reuptake inhibitor \- B. Alpha-2 adrenergic receptor antagonist \- C. Dopamine reuptake inhibitor \- D. GABA receptor agonist \*\*Answer:\*\* B. Alpha-2 adrenergic receptor antagonist【67:0†source】 2\. \*\*Which of the following is a common side effect of mirtazapine?\*\* \- A. Weight loss \- B. Hypertension \- C. Weight gain \- D. Sexual dysfunction \*\*Answer:\*\* C. Weight gain【67:0†source】 3\. \*\*Mirtazapine is less likely to cause which side effect compared to SSRIs?\*\* \- A. Sedation \- B. Sexual dysfunction \- C. Weight gain \- D. Dry mouth \*\*Answer:\*\* B. Sexual dysfunction【67:0†source】 \-\-- \#\#\# \*\*Slide 54: Vortioxetine (Trintellix)\*\* 1\. \*\*What is the primary mechanism of action of vortioxetine?\*\* \- A. Dopamine reuptake inhibitor \- B. Serotonin transporter (SERT) inhibitor \- C. NMDA receptor antagonist \- D. Alpha-2 adrenergic agonist \*\*Answer:\*\* B. Serotonin transporter (SERT) inhibitor【67:0†source】 2\. \*\*Which of the following receptors does vortioxetine partially agonize?\*\* \- A. 5-HT1A \- B. NMDA \- C. GABA-A \- D. Alpha-1 adrenergic \*\*Answer:\*\* A. 5-HT1A【67:0†source】 3\. \*\*Which of the following is a common side effect of vortioxetine?\*\* \- A. Diarrhea \- B. Nausea \- C. Bradycardia \- D. Weight gain \*\*Answer:\*\* B. Nausea【67:0†source】 \-\-- \#\#\# \*\*Slide 55: Vilazodone (Viibryd)\*\* 1\. \*\*Vilazodone acts as a partial agonist at which receptor?\*\* \- A. 5-HT1A receptor \- B. NMDA receptor \- C. Alpha-2 adrenergic receptor \- D. GABA-B receptor \*\*Answer:\*\* A. 5-HT1A receptor【67:0†source】 2\. \*\*What is a significant adverse effect associated with vilazodone that requires monitoring?\*\* \- A. Long QT syndrome \- B. Hypertensive crisis \- C. Weight gain \- D. Hepatotoxicity \*\*Answer:\*\* A. Long QT syndrome【67:0†source】 3\. \*\*Vilazodone's mechanism enhances serotonergic activity by inhibiting which transporter?\*\* \- A. SERT (Serotonin transporter) \- B. DAT (Dopamine transporter) \- C. NET (Norepinephrine transporter) \- D. GAT (GABA transporter) \*\*Answer:\*\* A. SERT (Serotonin transporter)【67:0†source】