Drug Information PDF

+-----------+-----------+-----------+-----------+-----------+-----------+ | Drug | **Aceprom | **Midazol | **Medetom | **Atipame | **Tiletam | | | azine | am** | idine | zole | ine- | | | (a.k.a | | (a.k.a | (a.k.a | zolazepam | |...

+-----------+-----------+-----------+-----------+-----------+-----------+ | Drug | **Aceprom | **Midazol | **Medetom | **Atipame | **Tiletam | | | azine | am** | idine | zole | ine- | | | (a.k.a | | (a.k.a | (a.k.a | zolazepam | | | ace or | | domitor)\ | antisedan | (a.k.a | | | ACP)\*** | | *** | )\*** | zoletil)\ | | | | | | | *** | +===========+===========+===========+===========+===========+===========+ | drug | Phenothia | Benzodiaz | α~2~- | α~2~- | NMDA | | class | zine | epine | adrenergi | adrenergi | antagonis | | | | | c | c | t- | | | | | agonist | antagonis | benzodiaz | | | | | | t | epine | +-----------+-----------+-----------+-----------+-----------+-----------+ | Mode of | dopamine  | -CNS | blood | Competiti | Injectabl | | action | receptor | depressio | pressure | vely | e | | | antagonis | n | is | inhibits | anaesthet | | | t | results | initially | α~2~- | ic/ | | | in the | in muscle | increased | adrenergi | tranquili | | | CNS | relaxatio | due to | c | ser | | | | n | periphera | receptors | combinati | | | | and | l | , | on | | | | sedation | vasoconst | thereby | | | | | | riction | acting as | | | | | -anxiolyt | and | a | | | | | ic | thereafte | reversal | | | | | | r | agent for | | | | | | drops to | α~2~- | | | | | | normal or | adrenergi | | | | | | slightly | c | | | | | | below | agonist | | | | | | normal | | | | | | | levels. | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | Indicatio | -Sedation | -Premedic | -Sedation | Reversal | -Dissocia | | n | | ation | | of | tive | | | -muscular | for GA | -analgesi | sedation | anaesthet | | | relaxatio | | a | | ic | | | n | -Treatmen | | | | | | | t | | | -Analgesi | | | -reductio | of | | | a | | | n | seizures | | | | | | in | | | | -Protecti | | | spontaneo | | | | ve | | | us | | | | reflexes | | | activity | | | | retained | | | | | | | (eg. | | | | | | | Swallowin | | | | | | | g) | | | | | | | | | | | | | | -Good for | | | | | | | short, | | | | | | | minor | | | | | | | painful | | | | | | | procedure | | | | | | | s | +-----------+-----------+-----------+-----------+-----------+-----------+ | Side | -Hypotens | -Respirat | -Bradycar | -Vomiting | -Ptyalism | | effect | ion | ory | dia | and | (hypersal | | | | depressio | and | diarrhoea | ivation) | | | -Bradycar | n | hypotensi | | | | | dia | | on | -Hypersal | -Respirat | | | | -Can | | ivation | ory | | | -Decrease | cause | -Hypother | | depressio | | | d | excitabil | mia | -Tremours | n | | | tear | ity | | | | | | productio | in cats | -vomiting | -excitati | -Tachycar | | | n | | | on | dia | | | (cats) | | | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | Contraind | -Hepatic, | -Cautious | -Systemic | -Not | -Pancreat | | ications/ | cardiac | use in | disease | recommend | ic | | precautio | disease | sick/ | (cardiac, | ed | disease | | ns/ | | debilitat | respirato | in | | | warnings | -Aggressi | ed | ry, | pregnant | -Renal | | | ve | patients | renal, | or | disease | | | animals | | hepatic) | lactating | | | | | -Hypersen | | animals | -Severe | | | -Dogs | sitivity | -Can make | | cardiac | | | with MDR1 | | aggressio | -Caution | and | | | mutation | | n | in | respirato | | | more | | worse in | elderly | ry | | | profound | | some | or | disease | | | sedation | | animals | debilitat | | | | | | (rare) | ed | -Pregnant | | | -Most | | | animals | animals | | | will | | | | | | | require | | | | | | | lower | | | | | | | anaesthet | | | | | | | ic | | | | | | | doses | | | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | Reversibl | No | no | yes | \- | no | | e? | | | | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | Controlle | yes | yes | yes | yes | yes | | d | | | | | | +-----------+-----------+-----------+-----------+-----------+-----------+