Anorectic Agents PDF

## Anorectic Agents **Use:** Anorexia, antiobesity **Act on Hypothalamus at satiety centre** - Phentermine - Phenylpropanolamine - Sibutramine - don't use, biz of Cardiac 8/2, risk of abused drug - Fenfluramine - Dexfenfluramine ## NALO **CNS Stimulant Effects:** e.g Amphetamine, Ephedrine...

## Anorectic Agents **Use:** Anorexia, antiobesity **Act on Hypothalamus at satiety centre** - Phentermine - Phenylpropanolamine - Sibutramine - don't use, biz of Cardiac 8/2, risk of abused drug - Fenfluramine - Dexfenfluramine ## NALO **CNS Stimulant Effects:** e.g Amphetamine, Ephedrine - Methylphenidate - DOC ADHD, abused by athletes, - preferred to Modafinil - Ephedrine - abused by athletes - DOC Narcolepsy - CNS Stimulants, fatigue, ↑ cooperative test **Methylphenidate** - Attention Deficit Hyperactive Disorder - to ↑↑ attention CNS, Stimulant (+) - Narcolepsy - Sleep disorder (uncontrollable sleep attacks) - attacks at any situations any when ## B-Agonists **e.g Bronchodilators (B2) Asthma** - Salbutamol likedry - uterine relaxants (tocolytics) (B2) COPD - e.g Ritadrine, Isoxusprines - use to delay labor ## B3-Agonist - e.g mirabegrot **Bladder relaxant** **Use:** Overactive bladder, aulous burnew - Adipose tissue - antiobesity drug (not approved for obesity) ## Imourably Acting S.Mimetis - TCAs - SNRIs - Cocaine - Tyramine - Ephedrine **Sympatholytics** | | directly | indirectly | |---|---|---| | ↓ | | | | VD | | [JMA ax] | | | | | | | # | | | | ↓ | | | | Relieve the wincoutflow obstructs | | | | | | **Miost, Use HTN HE** | | | | |---|---|---| | | Peripheral vascular disease | | | Male Impotence/Erectile dysfunction | | | | | | | | | VD property | | | | | | | | | | | | Relieve Urine Outflow obstructions | | | | | | | | Benign Prostatic Hypertrophy (BPH) Cenlargement of prostate | | **Rise of Constantio or postava H-TH due to wrine Obst.** - **Terazosin** - less risk of hypotension (mayman 1st dose Stat - C) - **Doxazosin** - HTN & fo BPH & Both (Minimal dose to Prevent it at bed time) - **Tamsulosin** - HTN in dyslipidemia (Pts [DO]) - **Si lo dain** - GOPH HE ## 5/e - Hypotension (postural) - Ejaculation failure (sepuls/2) - Retrograde ejection - Floppy eye syndrome (miolris) **Non Selecture** - [2, ß2 both] | | Im Brodrug (Slow) | Rever (Faster & Short) | |---|---|---| | | | | | | Phenoxy tongr benzemine | Phentolamine, Tolosalde | | | | | | | | Phenoxybenzamine (to control BP) | **USE → HTN RX** - Cheese Rith withdrawal y phentolamin (DOC) - Not use PVD * Risk of Hypotension less then 21 | | | | |---|---|---| | | 2,0 | | | 2,0 | THA | | | | TSBP | | | | | | **Elective L-Blockn** | | | | |---|---|---| | | | | | ↓ | | ↓ | | | Pueyosin | Yohimbine/Rocolsaame | ## B Blocker | | Nonselective | Selecttive | |---|---|---| | | | | | | CB+ | Cardio | | | | | | | e.g Propanolol | e.g Atenol | | | | | | | Nadolol | A2 - acebutolol | | | | | | | Sotalol | B2 - Betoxolol | | | | | | | Pindolol | Celi propol | | | | | ## Metoprolol, Ermolal, Nebivol **Adv. of cardioselectivity** - No risk asthmatic pt. & COPD - No risk of suppressios guerncogenesis in (Quart) - Safr in Diabetic pt. - No risk of Coursing dyscipiderria (espagexeris) DMA & dyslipidemic pt - No risk of Coursing uterine obstruction - No risk of glycogenesis in sk. musde → Athletes... **USE of 2-B0** | Cardiac Uses | Non Cardiac Uses | |---|---| | | | | | | | ↓ | | | | | | | | (Heart pts) | | | | | | | | Cardiosecetrine BO MI, angine, HTN | | | | | | | | Heart failure, Arrhythmia | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | VD | | | | | | | | fentotamise | | | | | | | | | | | | deforest | | | | | | | | LA | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | (miotics) |- | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 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