Chapter 24 Metabolism and Nutrition PDF

CHAPTER 24 Metabolism and Nutrition 24.1 – Overview of Metabolic Reactions Catabolic – breaking down molecules (food) to release energy Anabolic – producing larger molecules by using the energy from catabolism If net energy change is positive, we store energy (glycogen, fat) If net energy is negativ...

CHAPTER 24 Metabolism and Nutrition 24.1 – Overview of Metabolic Reactions Catabolic – breaking down molecules (food) to release energy Anabolic – producing larger molecules by using the energy from catabolism If net energy change is positive, we store energy (glycogen, fat) If net energy is negative, we use stored energy 24.1 – Catabolic Reactions Energy is released from the chemical bonds 40% of energy goes toward ATP, the energy currency of the body 60% of energy is given off as heat ATP – Adenine, ribose, and a phosphate group. Result is ADP and P Carbohydrates break down to glucose which is the most common fuel for ATP Glucose is used for fuel, stored as glycogen, or converted into fat Fat is stored and triglycerides are used for energy in beta oxidation Protein breaks down into AA which can build other proteins or be used for energy 24.1 – Anabolic Reactions Monosaccharides form polysaccharides Fatty acids form triglycerides Amino acids form proteins Nucleotides form nucleic acids 24.1 – Hormone Regulation Cortisol, glucagon, and epinephrine are catabolic Growth hormone, IGF, insulin, testosterone, and estrogen are anabolic 24.1 – Oxidation-Reduction reaction Redox reaction – electron passes between molecules, the donor is oxidized and the recipient is reduced Often a series of reactions to combine ADP and P These reactions are catalyzed by enzymes that remove the hydrogen atom 24.2 – Carbohydrate Metabolism Glycolysis – cells take up glucose in response to insulin Glycolysis uses 2 ATP to form 4 ATP, 2 NADH molecules, and 2 pyruvate molecules Pyruvate continues on to the Krebs cycle if O2 is present NADH will produce more ATP later in the mitochondria Anaerobic – pyruvate is converted to lactic acid which generates 1 ATP and lets glycolysis continue Aerobic – pyruvate enters the Krebs cycle, electrons are passed to the electron transport chain, and more ATP is produced 24.2 – Krebs Cycle/Citric Acid Cycle/ Tricarboxylic Cycle Pyruvate moves into matrix of the mitochondria and is metabolized by enzymes Pyruvate becomes acetyl CoA (a double carbon + Coenzyme A) Acetyl CoA combines with oxaloacetate to form citric acid Citric acid breaks down through the cycle until it becomes oxaloacetate again 3 high energy molecules are created – ATP, NADH, and FADH2 NADH and FADH2 pass electrons to the electron transport chain for more ATP, they are known as electron donors Each citric acid molecule produces 1 ATP, 1 FADH2, and 3 NADH 24.2 – Electron Transport Chain (ETC) NADH and FADH2 are transferred through protein complexes NADH → NAD+ and H+ and 2e As molecules are oxidized and reduced energy is released to pump H+ out of the matrix H+ now forms a gradient and finds ATP synthase to move back into the matrix causing the complex to rotate and push ADP together with inorganic P 2e- and 2H+ and ½ O2 → H2O Electrons are transferred to O2 which is why we need O2 to live End result is 38 ATP produced from glycolysis, Krebs cycle, and ETC 24.2 - Gluconeogenesis Making glucose in the liver from pyruvate, lactate, glycerol, alanine, or glutamine Happens due to low glucose (fasting, starving, dieting)