Summary

This document appears to be a set of lecture slides or notes covering introductory biology. It delves into fundamental concepts such as the properties of life, biological organization, two types of reasoning in science, and the structure of macromolecules. It also discusses concepts such as evolution and natural selection, and the central dogma of molecular biology, including DNA replication, transcription, and translation.

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Properties of Life All living organisms share eight (8) key characteristics or functions: Order sensitivity or response to the environment reproduction adaptation growth and development regulation/homeostasis energy processing evolution. All molecules, FIGURE 1.15 inc...

Properties of Life All living organisms share eight (8) key characteristics or functions: Order sensitivity or response to the environment reproduction adaptation growth and development regulation/homeostasis energy processing evolution. All molecules, FIGURE 1.15 including this DNA molecule, are composed of atoms. The Order observed in living things begins with: ATOMS = > MOLECULES => MACROMOLECULES (e.g. Proteins, Lipids, DNA, RNA, carbohydrates). Macromolecules build => The biological levels of organization of living things are shown. From a single organelle to the entire biosphere, living organisms are parts of a highly structured hierarchy. FIGURE 1.7 Scientists use two types of reasoning, inductive and deductive reasoning, to advance scientific knowledge. As is the case in this example, the conclusion from inductive reasoning can often become the premise for deductive reasoning. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. Implications / Deductions Laws of the Observations Real World of the Real World Inferences / Inductions Descriptive vs. Inferential Statistics FIGURE 20.2 FIGURE 20.3 The root of a phylogenetic tree indicates that an ancestral lineage gave rise to all organisms on the tree. A branch point indicates where two lineages diverged. A lineage that evolved early and remains unbranched is a basal taxon. When two lineages stem from the same branch point, they are sister taxa. A branch with more than two lineages is a polytomy. FIGURE 20.4 This ladder-like phylogenetic tree of vertebrates is rooted by an organism that lacked a vertebral column. At each branch point, organisms with different characters are placed in different groups based on the characteristics they share. BIOLOGY 2e Chapters 2 &BIOLOGY forMacromolecules 3 Chemicals and AP® COURSES Chapter # Chapter Title PowerPoint Image Slideshow FIGURE 2.13 The polarity of water. The polarity of water is due to the differing electronegativities of hydrogen and oxygen. As a consequence, hydrogen bonds are formed when the slightly negative oxygen on one water molecule is attracted to the slightly positive hydrogen of another water molecule. (credit: Rao, A., Fletcher, S., Ryan, K., Tag, A. and Hawkins, A. Department of Biology, Texas A&M University) This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 2.28 Hydrogen bonds connect two strands of DNA together to create the double-helix structure. FIGURE 3.2 DEHYDRATION Reaction In the dehydration synthesis reaction depicted above, two molecules of glucose are linked together to form the dissacharide maltose. In the process, a water molecule is formed. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.3 HYDROLYSIS Reaction In the hydrolysis reaction shown here, the disaccharide maltose is broken down to form two glucose monomers with addition of water. Note that this reaction is the reverse of the synthesis reaction shown in Figure 3.2. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.22 – AMINO ACIDS (MONOMERS USED TO MAKE PROTEINS. Amino acids have a central asymmetric carbon to which an amino group, a carboxyl group, a hydrogen atom, and a side chain (R group) are attached. FIGURE 3.23 There are 20 common amino acids found in proteins, each with a different R group (variant group) that determines its chemical nature. FIGURE 3.24 Peptide bond formation is a dehydration synthesis reaction. The carboxyl group of one amino acid is linked to the amino group of the incoming amino acid. In the process, it releases a water molecule. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.30 This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.31 A nucleotide is made up of three components: a nitrogenous base, a pentose sugar, and one or more phosphate groups. Carbon residues in the pentose are numbered 1′ through 5′ (the prime distinguishes these residues from those in the base, which are numbered without using a prime notation). The base is attached to the 1′ position of the ribose, and the phosphate is attached to the 5′ position. When a polynucleotide is formed, the 5′ phosphate of the incoming nucleotide attaches to the 3′ hydroxyl group at the end of the growing chain. Two types of pentose are found in nucleotides, deoxyribose (found in DNA) and ribose (found in RNA). Deoxyribose is similar in structure to ribose, but it has an H instead of an OH at the 2′ position. Bases can be divided into two categories: purines and pyrimidines. Purines have a double ring structure, and pyrimidines have a single ring. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.32 Native DNA is an antiparallel double helix. The phosphate backbone (indicated by the curvy lines) is on the outside, and the bases are on the inside. Each base from one strand interacts via hydrogen bonding with a base from the opposing strand. (credit: Jerome Walker/Dennis Myts) This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 3.33 In a double stranded DNA molecule, the two strands run antiparallel to one another so that one strand runs 5′ to 3′ and the other 3′ to 5′. The phosphate backbone is located on the outside, and the bases are in the middle. Adenine forms hydrogen bonds (or base pairs) with thymine, and guanine base pairs with cytosine. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. On the Origin of Species – Charles Darwin A struggle for existence inevitably follows from the high rate at which all organic beings tend to increase. Every being, which during its natural lifetime produces several eggs or seeds, must suffer destruction during some period of its life, and during some season or occasional year, otherwise, on the principle of geometric increase, its numbers would quickly become so inordinately great that no country could support the product. Hence, as more individuals are produced than can possibly survive, there must in every case be a struggle for existence…It is the doctrine of Malthus applied with manifold force to the whole animal and vegetable kingdoms…There is no exception to the rule that every organic being naturally increases at so high a rate, that if not destroyed, the earth would soon be covered by the progeny of a single pair. …Owing to this struggle for life, any variation, however slight and from whatever cause proceeding, if it be in any degree profitable to an individual of any species…will tend to the preservation of that individual, and will be inherited by its offspring. The offspring, also, will thus have a better chance of surviving, for, of the many individuals of any species which are periodically born, but a small number can survive. I have called this principle, by which slight variation, if useful, is preserved, by the term Natural Selection. [Darwin 1859, 61–62] Evolution is the change in the genetic composition of a population over time. Evolution by natural selection occurs when (1) heritable variations leads to (2) differential reproductive success. Natural selection acts on individuals in a population but only populations evolve. FIGURE 18.7 Evidence of Evolution The similar construction of these appendages indicates that these organisms share a common ancestor. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. Evolution leads to new species. But what is a species? Evolution within a population = microevolution. Origin of new species = macroevolution. Table 27.1 Figure 27.8 (a) Formation of autopolyploid (b) Formation of allopolyploid Diploid parent (2n) Diploid parents (2n  6 and 2n  4) of two different species Nondisjunction during meiosis Meiosis Meiosis Diploid gametes (2n) Haploid gametes (n) Fertilization Self-fertilization Hybrid offspring (effectively n) Sterile; two sets of chromosomes Tetraploid offspring (4n) do not synapse and separate normally during meiosis Error in mitosis prior to meiosis: chromosome number doubles Polyploidy and Sympatric Allopolyploid offspring (effectively 2n  10) Speciation Now each chromosome has a homolog and meiosis can take place to form gametes for the next generation FIGURE 19.8 Different types of natural selection can impact the distribution of phenotypes within a population. In (a) stabilizing selection, an average phenotype is favored. In (b) directional selection, a change in the environment shifts the spectrum of phenotypes observed. In (c) diversifying selection, two or more extreme phenotypes are selected for, while the average phenotype is selected against. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. Lecture 4: DNA and the Central Dogma of Biology Instructions on DNA are transcribed onto messenger RNA. Ribosomes are able to read the genetic information inscribed on a strand of messenger RNA and use this information to string amino acids together into a protein. Central Dogma! Translation of RNA bases to amino acids FIGURE 15.7 TRANSCRIPTION IN PROKARYOTES Transcription Bubble Non-Template Strand Template Strand Messenger RNA is a copy of protein-coding information in the coding strand of DNA, with the substitution of U in the RNA for T in the coding sequence. However, new RNA nucleotides base pair with the nucleotides of the template strand. RNA is synthesized in its 5'-3' direction, using the enzyme RNA polymerase. As the template is read, the DNA unwinds ahead of the polymerase and then rewinds behind it. This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 15.11 (credit: Rao, A., Ryan, K. Fletcher, S. and Tag, A. Department of Biology, Texas A&M University) This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 15.16B (credit: Rao, A., Ryan, K. Fletcher, S. and Tag, A. Department of Biology, Texas A&M University) This OpenStax ancillary resource is © Rice University under a CC-BY 4.0 International license; it may be reproduced or modified but must be attributed to OpenStax, Rice University and any changes must be noted. Any images credited to other sources are similarly available for reproduction, but must be attributed to their sources. FIGURE 15.18 Translation begins when an initiator tRNA anticodon recognizes a start codon on mRNA bound to a small ribosomal subunit. The large ribosomal subunit joins the small subunit, and a second tRNA is recruited. As the mRNA moves relative to the ribosome, successive tRNAs move through the ribosome and the polypeptide chain is formed. Entry of a release factor into the A site terminates translation and the components dissociate. (credit: Rao, A., Ryan, K. Fletcher, S. and Tag, A. Department of Biology, Texas A&M University)

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