Introduction to Autonomic Pharmacology OPTM2021 PDF

Dr. Arlene Villarroel Stuart OPTM2021 1  Autonomic Nervous System  Cholinergic Agonists  Cholinergic Antagonists  Adrenergic Agonists  Adrenergic Antagonists 2  Neurotransmitter  Effector organ ...

Dr. Arlene Villarroel Stuart OPTM2021 1  Autonomic Nervous System  Cholinergic Agonists  Cholinergic Antagonists  Adrenergic Agonists  Adrenergic Antagonists 2  Neurotransmitter  Effector organ  Parasympathetic  Sympathetic  Somatic 3  Autonomic Nervous System Peripheral Central Nervous Nervous System System Efferent Afferent Brain and Division Division Spinal Cord 4  Efferent Division Autonomic Somatic System System Parasympathetic Sympathetic 5 6  Transmission of electrical impulses  Drugs – Autonomic drugs 7  Preganglionic - Acetylcholine (Ach)  Postganglionic - Noradrenaline 8 9  Acetylcholine + Enzyme -> Acetate + Choline  Noradrenaline: Absorption (Uptake I and Uptake II) 10 11 Cholinergic – Postganglionic fibres + effector cells  Nicotinic – sympathetic and parasympathetic (motor end plate skeletal muscle)  Muscarinic – ACh receptors on membrane of parasympathetic effector cells e.g. smooth muscle/glands 12 13 14  Antimuscarinic Agents  Ganglionic blockers  Neuromuscular blockers 15 16  Adrenergic – for sympathetic catecholamines (adrenoceptors) include:  Alpha-1 receptors – postsynaptic (smooth muscle)  Alpha-2 – presynaptic, at peripheral adrenergic nerve terminals  Beta-1 - heart  Beta-2 – smooth muscle  Dopamine – renal blood flow 17 18 19 20 21 22 23 24  Action  Therapeutic Uses  Pharmacokinetics  Adverse Effects 25 26