Pharmacology Made Easy: Medication Information Table (PDF)
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Uploaded by DignifiedRadon
Royal Holloway, University of London
2023
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Summary
This document is a medication information table that provides details on methotrexate, a Conventional Synthetic Nonbiologic (Traditional) DMARDs. It includes information on the therapeutic use, adverse drug reactions, interventions, administration, client instructions, contraindications, precautions, an drug interactions.
Full Transcript
Pharmacology Made Easy Medication Information Table Conventional Synthetic Nonbiologic (Traditional) DMARDs – methotrexate Category Information THERAPEUTIC USE...
Pharmacology Made Easy Medication Information Table Conventional Synthetic Nonbiologic (Traditional) DMARDs – methotrexate Category Information THERAPEUTIC USE Decrease joint inflammation and subsequently joint damage. ADVERSE DRUG Bone marrow suppression (decreased platelets, red and white blood cells) REACTIONS Increased risk of infection Liver damage Gastrointestinal ulceration Pulmonary fibrosis Dizziness and headache Nausea and vomiting INTERVENTIONS Monitor for decreased platelets, red and white blood cell counts. Monitor for manifestations of infection. Monitor liver function tests and observe for jaundice. Monitor for gastrointestinal bleeding (with methotrexate). Monitor for respiratory distress and decreased oxygenation. Monitor for abdominal pain, diarrhea, nausea, and vomiting. ADMINISTRATION Give methotrexate once a week via route prescribed (oral, subcutaneous, or intramuscular). Folic acid supplement may be prescribed to decrease risk of toxicity. CLIENT INSTRUCTIONS Report abnormal bleeding, bruising, or petechiae (pinpoint areas of blood under the skin). Report ulcerations of the mouth or tongue. Report manifestations of infection immediately. Avoid ingesting alcohol. Report yellowing of the skin and eyes immediately. Report blood in vomitus or stools. Report difficulty breathing or shortness of breath. Drink adequate amounts (2 L) of water daily to ensure excretion of medication. Follow advice of health care provider regarding contraception for clients of child-bearing age. Avoid breastfeeding while on this medication. Copyright ©2023 Assessment Technologies Institute, L.L.C. All rights reserved. This resource is copyright protected material of ATI and is provided for use solely under license by ATI. Copying, distributing, or posting this material on the internet or social media is strictly prohibited. Posting on institution LMS requires ATI’s prior written permission. PAGE 1 www.atitesting.com ©2023 Assessment Technologies Institute, L.L.C. Pharmacology Made Easy: Medication Information Table Conventional Synthetic Nonbiologic (Traditional) DMARDs – methotrexate Category Information CONTRAINDICATIONS Teratogenic (methotrexate) Liver insufficiency or hepatitis Renal insufficiency PRECAUTIONS Peptic ulcer or ulcerative colitis Active bacterial or viral infections INTERACTIONS Concurrent use of methotrexate and digoxin may reduce digoxin level. Concurrent use of methotrexate and NSAIDs, salicylates, and sulfonamides may cause toxicity. NSAIDs can be administered during the initial period until methotrexate has exhibited its therapeutic effect. Then they must be discontinued. Caffeine may reduce the effectiveness of methotrexate. Concurrent use of warfarin may increase the risk for bleeding. Alcohol use may increase risk of hepatotoxicity. PAGE 2 www.atitesting.com ©2023 Assessment Technologies Institute, L.L.C.
