Autoimmunity Fill In Blanks Meds-1 PDF

RA and Lupus Immunosuppressants NSAIDS and Steroids: BOTH Relieve ________________ NSAIDs: what do they do: Avoid in pts with: ______________________________ Ex: ________________ Steroids: Strong _______________________ Ex: _______ Work __________________ Goal: is to use __________________________...

RA and Lupus Immunosuppressants NSAIDS and Steroids: BOTH Relieve ________________ NSAIDs: what do they do: Avoid in pts with: ______________________________ Ex: ________________ Steroids: Strong _______________________ Ex: _______ Work __________________ Goal: is to use ____________________________________________ SE’s: ______________________________________________________ Therefore: not (usually) used for long term therapy Used with caution with those with________&___________ RA causes a decrease in bone density, which can lead to ___________________ The use of steroid medications, such as prednisone, further increases the risk of _____________________ Recommend adequate: ___ -Immunosuppressants: *** Good news: Helps body to stop attacking itself! But Bad news = __________________________________________ high risk for ____________ and **** high risk for _________________ **** DMARDs – disease modifying antirheumatic drugs How are DMARDs similar to NSAIDS?____ Differ?_____ These drugs:___________________________________________________________ ___________________________________________________________________ Two types: Non-biologic DMARD and Biologic DMARD Nonbiologic DMARD: __________________________________ Ex ___________________________________________________ Biologics DMARDS:___________________________________________________ Ex _______________________________________________________ Unlike conventional DMARDS which can take________________________, biologics tend to work__________________________  RA and Lupus Immunosuppressants Nonbiologic DMARDS: -Hydroxychloroquine (Plaquenil) Decreases _______________________ Will see increase energy- but takes ____________________to get to therapeutic level MAJOR adverse Effects__________________________________________ Benefits: _____________________________________________________- Is there a need for osteoporosis medications??? _______ Safe during pregnancy?? ________ -Methotrexate How does is work? _______________________________________________ Mainstay of therapy for RA b/c ___________________________________________ How long does it need to be taken before positive effects seen?__________________ MethOtrexate: NO ________________, NO ________________ NO __________________. No ___________________________ bone marrow suppression = ___________________ = _____________________ Thrombocytopenia = platelets under ___________. Must report bleeding! Includes: _________________________ _________________________ _________________________ _________________________ _________________________ Neutropenia = __________________________ = ________________ No________________ No________________ OK for________________ SO MUST report _________________________ A fetus has quickly replicating cells which could = _____________________ Do NOT __________________________ MUST Be on ___________________________ Need to be off more 3 months before _______________________  RA and Lupus Immunosuppressants Memory trick with MethOtrexate is Meth-NO-trexate! No _____________________________ No _____________________________ No _____________________________ No _____________________________ No _____________________________ Time to see benefits:_____________________________ If no response after 2 months _______________________ Azathioprine (Imuran) and Cyclosporine: Common side effect for Cyclosporine: _________________ Report?________________________ Patient teaching: _____________________(true for 99% of all drugs!) Biologic DMARD: Timeline of effects: ____________________________________________________ Cost: ____________________________ High risk for developing _____________________________________________________ Must have _____________________ to start! And test____________ Must __________________________ once start. Must avoid ______________________________ Stay away from: ________________________ Key Point: REPORT _________________ Report _________________ Pt Education: Must have _____________________ to start! b/c______________________ Contraindication____________________________________ What lab is EXPECTED to be elevated________________ Ex for Lupus:_______________ Ex for RA: TNF inhibitors _____________________________________ _____________________________________________________ Why are TNF inhibitors not given to those with Lupus??______