Antibiotics Part 3 PDF
Document Details
Uploaded by NiceHeliotrope2109
Tags
Summary
This document covers different bacterial groups, infection sites, and the mechanisms of action and resistance of antibiotics. The information includes classification and mechanisms of action, resistance mechanisms, and selection of appropriate antimicrobials. It appears to be part of a larger lecture or course on microbiology.
Full Transcript
Bacterial groups and infection sites Bacterial Meningitis Otitis media RTIs GI: Gram +ve and –ve, and anaerobes e.g....
Bacterial groups and infection sites Bacterial Meningitis Otitis media RTIs GI: Gram +ve and –ve, and anaerobes e.g. Enterobacteriacea - Chlamydia - Gonorrhea - Syphilis Mostly Gram +ve aerobes - Bacterial vaginosis - Cellulitis - Folliculitis - Impetigo Wound Source UTI Mechanisms of action of antibiotics Antibiotics classification and mechanisms of actio n Start Smart then Focus Toolkit Mechanisms of resistance Penetration resistance Efflux pump Hydrolysis Mutation of the binding site Selection of appropriate antimicrobials Selection of appropriate antimicrobials Penicillins Beta-lactamase sensitive: benzylpenicillin (penicillin G), phenoxymethylpenicillin (penicillin V) P+BF: NOT known to be harmful Broad-spectrum (but inactivated by beta- lactamases): amoxicillin and ampicillin Cautions & contraindications: Penicillinase-resistant penicillin: Hypersensitivity (1-10%) and anaphylaxis flucloxacillin. (
