Antibiotic Synthesis and Drug Roles PDF
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Temple University
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Summary
This document details the synthesis of cell walls and the roles of specific drugs in antibiotics. It outlines the similarities and differences between various types of beta-lactam antibiotics and their application in treating different bacterial infections. It also describes the mechanism of action for different antibiotics and their impact.
Full Transcript
## **Synthesis of Cell Wall** 1. Producing the monomer 2. Structures add up to make polymer 3. Linkage 4. Cross linkage ## **Specific Drug Role in Antibiotics** * **Fosfomycin**: inhibit monomer * **Vancomycin and teicoplanin**: prevent bacteria wall from getting longer * **Beta Lactam**: preven...
## **Synthesis of Cell Wall** 1. Producing the monomer 2. Structures add up to make polymer 3. Linkage 4. Cross linkage ## **Specific Drug Role in Antibiotics** * **Fosfomycin**: inhibit monomer * **Vancomycin and teicoplanin**: prevent bacteria wall from getting longer * **Beta Lactam**: prevents cross linking of cell wall ## **Beta Lactam Similarities and Differences** ### **Similarities** * Mechanism of Action * Good tissue penetration * Pharmacodynamics * Renal Elimination * Short Half Lives * Bactericidal * **Adverse Effects**: Nausea, hypersensitivity, diarrhea ### **Differences** * Absorption * Hydrophilicity * Types of PBP targeted * Stability against degradation ## **Aminopenicillin** * Ampicillin, amoxicillin * Susceptible to beta lactamases, main uses in URI, ulcer disease ## **Beta Lactamase** * This destroys the drug, targets beta lactams ## **Natural Penicillin Routes** * Penicillin G- IV only * Penicillin V- PO only * Penicillin G Benzathine - IM only ## **Antistaphylococcal Penicillin** * Not well absorbed * Widely available * Resistant to penicillin * Need to use nafcillin, oxacillin, dicloxacillin
