Depression & Antidepressants PDF

KSectives Inhibitor reuptake...

KSectives Inhibitor reuptake Deloxetine pain fornuropathic Psychiatric Exagatoman a aid't Kimm T.is NElsssg jjdhyperpyrexia o serotoninsyndromb Depression: serotonin bReuptakeofserotonin Depression + seizure: 8hpm Antidepressants used in patient with epilepsy with/without HTN: Paroxetine (SSRIs) Antidepressants should AVOID in seizure: Bupropion Tseizures I Depression + weight: DOC for depression patient who is obese: Bupropion, Venlafaxine Tseizures DOC for epileptic patient who loss of appetite: Mirtazapine forobese lesssedation # antidepressants act on which area in brain !: Postsynaptic d # anxiolytics with least sedation and withdrawal symptoms: bupropion in SSRI Examples Obese: Bupropionivanlafaxin citalopram (Cipramil Thin: Mirtazapine dapoxetine (Priligy Cardiac ❤: Sertraline orParoxetine SSRI s Seizure: Escitalopram anyone escitalopram (Cipralex SII Anxiety #: SSRIs uoxetine (Prozac or Oxactin uvoxamine (Faverin Insomnia $: Mirtazapine, Paroxetine paroxetine (Seroxat Pregnant %: Sertraline sertraline (Lustral Breastfeeding &: Sertraline, Paroxetine vortioxetine (Brintellix) means Cause cardiac anomalies I CI inpregnancy TCA: for baby Secondary: Protriptyline, Nortriptyline, Desipramine utilit es Tertiary: Doxepin, Amitriptyline, Imipramine, Clomipramine, Trimipramine. # Amitriptyline cause arrhythmia i i MOA-I: Monoamine oxidase inhibitors (MAOIs) # tyramine à cause hypertension crisis A. Non selective (MAO-A, MAO-B inhibitors): Phenelzine, Tranylcypromine, isocratic #irreversible B. Selective MAO-A inhibitors: Moclobemide # reversible C. Selective MAO-B inhibitors: Rasgiline, Selegiline # Tablet Selegilin for Parkinson disease (PD), Transdermal patch for depression Drug switching: - Other anti-depressant à ßMAO-I: 2-weeks washout period Antidepeta qbsbeia.si j - # EXCEPT fluoxetine it is self-taper 4-5 weeks washout period ooiGa mIjIeMAOIS.E ii fluoxetine Bupropion: Not use in seizure, Pregnant Used in case of Sexual dysfunction (SD) developed after SSRIs à DOC of SD caused by SSRIs Use in obese patient with depression (decrease weight) Bupropion Combinationbismia