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# Factors affecting wound healing ## Oxygenation * Oxygen is essential for wound healing * It prevents infection, induces angiogenesis, enhances collagen synthesis, and re-epithelialization * Due to vascular disruption and high oxygen consumption by metabolically active cells, the microenvironment...

# Factors affecting wound healing ## Oxygenation * Oxygen is essential for wound healing * It prevents infection, induces angiogenesis, enhances collagen synthesis, and re-epithelialization * Due to vascular disruption and high oxygen consumption by metabolically active cells, the microenvironment of the early wound is depleted of oxygen and is quite hypoxic. * If oxygenation is not restored, healing is impaired * Sometimes the use of hyperbaric oxygen therapy improves healing in a room called a hyperbaric oxygen chamber. * Exposing a wound to 100% oxygen may speed healing. ## Infection | Contamination | Colonization | Infection | |---|---|---| | Presence of non-replicating micro-organism without causing any type of infection | Presence of replicating micro-organism in the wound without wound damage. | Presence of replicating micro-organism in the wound with injury of tissues (requires AB). |