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# SECTION V. ANTIBIOTICS FOR TUBERCULOSIS **001. Select a drug that acts only on mycobacteria:** a) + Isoniazid b) Streptomycin sulphate c) Rifampicin d) Kanamycin sulphate **002. Identify the drug that is related to hydrazides of isonicotinic acid:** a) Rifampicin b) + Isoniazid c) Ethambutol d...

# SECTION V. ANTIBIOTICS FOR TUBERCULOSIS **001. Select a drug that acts only on mycobacteria:** a) + Isoniazid b) Streptomycin sulphate c) Rifampicin d) Kanamycin sulphate **002. Identify the drug that is related to hydrazides of isonicotinic acid:** a) Rifampicin b) + Isoniazid c) Ethambutol d) Ethionamide **003. Isoniazid exhibits antivitamin activity against:** a) Vitamin B₁ b) + Vitamin B₆ c) Vitamin C d) Vitamin D **004. Indicate the mechanism of action of isoniazid:** a) Inhibition of protein synthesis b) + Disruption of mycolic acid synthesis c) Inhibition of RNA synthesis d) Inhibition of ATP synthesis **005. Which of the listed anti-tuberculosis drugs belongs to aminoglycoside antibiotics?** a) Isoniazid b) + Streptomycin c) Rifampicin d) Ethambutol **006. Indicate the mechanism of action of streptomycin:** a) Inhibition of cell wall synthesis b) + Disruption of protein synthesis at the ribosomal level c) Inhibition of nucleic acid synthesis d) Disruption of cytoplasmic membrane permeability **007. Indicate the adverse effect characteristic of streptomycin:** a) Cardiotoxicity b) Dyspeptic symptoms c) Alteration in perception of yellow and green colours d) + Damage to the VIII cranial nerve **008. Indicate the mechanism of action of PAS:** a) Inhibition of mycolic acid synthesis b) + Competitive interaction with para-aminobenzoic acid c) Inhibition of DNA-dependent RNA polymerase d) Inhibition of DNA gyrase **009. What principle of tuberculosis therapy allows delaying the development of mycobacterium resistance to chemotherapeutic agents?** a) Monotherapy with an increased dose of the drug b) + Combination therapy using 2 or more drugs with different mechanisms of action c) Prolonging the treatment duration d) Combination therapy using 2 or more drugs with similar mechanisms of action