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Tuberculosis Drug Mechanisms

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Questions and Answers

Which drug specifically targets mycobacteria?

Isoniazid (correct)

Streptomycin sulphate

Kanamycin sulphate

Rifampicin

Which drug is associated with hydrazides of isonicotinic acid?

Ethambutol

Ethionamide

Isoniazid (correct)

Rifampicin

Isoniazid has an antivitamin effect primarily against which vitamin?

Vitamin C

Vitamin B₁

Vitamin D

Vitamin B₆ (correct)

What is the mechanism of action of isoniazid?

Disruption of mycolic acid synthesis Signup and view all the answers

Which anti-tuberculosis drug is classified as an aminoglycoside antibiotic?

Streptomycin Signup and view all the answers

What mechanism does streptomycin use to combat mycobacterial infections?

Disruption of protein synthesis at the ribosomal level Signup and view all the answers

Which adverse effect is particularly associated with the use of streptomycin?

Damage to the VIII cranial nerve Signup and view all the answers

What is the mechanism of action of para-aminosalicylic acid (PAS)?

Competitive interaction with para-aminobenzoic acid Signup and view all the answers

What principle of tuberculosis therapy helps in delaying mycobacterium resistance?

Combination therapy using 2 or more drugs with different mechanisms of action Signup and view all the answers

Study Notes

Tuberculosis Drugs

Specific Mycobacterial Action: Isoniazid is a drug that only affects mycobacteria.
Isoniazid & Hydrazide Relationship: Isoniazid is related to hydrazides.
Anti-Vitamin Activity: Isoniazid is an anti-vitamin B complex drug.
Isoniazid Mechanism: Inhibits mycolic acid synthesis.
Streptomycin Mechanism: Disrupts protein synthesis at the ribosome level.
Streptomycin Side Effect: Hearing loss.
PAS Mechanism: Competes with para-aminobenzoic acid (PABA).
Multi-Drug Therapy (MDR): Using multiple drugs to treat tuberculosis can slow the development of drug resistance.

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Description

Explore the mechanisms and actions of drugs used in the treatment of tuberculosis, focusing on Isoniazid, Streptomycin, and PAS. Learn how these medications interact with mycobacterial processes and the importance of multi-drug therapy in preventing resistance.