Systemic Lupus Erythematosus PDF

Systemic Lupus Erythematosus What is SLE? An autoimmune disease in which organs and cells undergo damage initially mediated by tissue binding autoantibodies and immune complexes. 90% are women in childbearing age. 5.5-6.5x more prevalent in women than men...

Systemic Lupus Erythematosus What is SLE? An autoimmune disease in which organs and cells undergo damage initially mediated by tissue binding autoantibodies and immune complexes. 90% are women in childbearing age. 5.5-6.5x more prevalent in women than men Harrison’s Principles of Internal Medicine, 21st Edition Predisposing Factors Genetics Genetic variants, DNA breaks, mutations, defects 44% contribution of genetic hereditability Environmental exposure UV light, smoking, silica, EBV infection, hormones, obesity, less than 7hrs of sleep, PTSD, Drugs (procainamide, hydralazine, INH, minocycline, TNF inhibitors) Harrison’s Principles of Internal Medicine, 21st Edition and Firestein & Kelleys Textbook of Rheumatology, 12th ed.  Genetic and Pathophysiology Environment Abnormal Autoantibody Immune Complex responses formation Deposition into the different organs Activation of Inflammatory pathways Harrison’s Principles of Internal Medicine, 21st Edition and Firestein & Kelleys Textbook of Rheumatology, End Organ Damage 12th ed. Atherosclerosis Nephritis Arthritis Serositis CNS cerebritis Carditis Leukopenia Clinical Criteria 2012 Systemic Lupus International Collaborating Clinics 2019 EULAR/ACR Classification  2012 Systemic Lupus International Collaborating Clinics Harrison’s Principles of Internal Medicine, 21st Edition 2012 Systemic Lupus International Collaborating Clinics Antiphospholipid, AntiDsDNA, Anti Smith Low serum complements and positive Coombs  2019 EULAR/ACR Classification Harrison’s Principles of Internal Medicine, 21st Edition  Clinical Manifestations Harrison’s Principles of Internal Medicine, 21st Edition Harrison’s Principles of Internal Medicine, 21st Edition Management There is no cure for SLE and complete and sustained remissions are rare Systemic Lupus Erythematosus Disease Activity Score – 2K – score to determine low level disease activity Harrison’s Principles of Internal Medicine, 21st Edition Firestein & Kelleys Textbook of Rheumatology, 12th ed. Firestein & Kelleys Textbook of Rheumatology, 12th ed. Thank You.