Tables PDF - Mutations in Driver Genes

Table 1. Frequency of mutations of driver genes of different classes in all tumor samples Oncogenes Tumor suppressor genes Kinases Phosphatases Transcription factors 89.4 90.5 61.8...

Table 1. Frequency of mutations of driver genes of different classes in all tumor samples Oncogenes Tumor suppressor genes Kinases Phosphatases Transcription factors 89.4 90.5 61.8 19.3 72.2 Table 2. Frequency of altered genes encoding transcription factors, kinases, phosphatases, oncogenes, and tumor suppressor genes in the most common cancers Colorecta Lung Breast Prostate Stomach Liver Thyroid Cervix Bladder l cancer Oncogenes 98.3 92.9 98.2 86.3 96.7 92.6 93.3 97.9 93.3 Tumor suppressor 98.85 95.1 99.3 93.7 99.5 97.3 50.9 95.2 94.2 genes Kinases 87.3 68.4 79.4 55.6 75.2 58 73.3 71.9 79.2 Phosphatases 35.45 11.5 31.5 31.8 41.1 16.6 3.5 11.6 19.9 Transcription 92.3 79.2 94.6 72.3 92.6 81.4 21.4 76.7 86.9 factors Table 3. Frequency of mutations in certain genes in different types of cancer Lung Breast Colorectum Prostate Stomach Liver Thyroid Cervix uteri Bladder CDK4 0.34 0.09 1.18 0.41 1.21 0.17 0 2.06 1.06 CDK6 1.82 0.26 1.33 4.23 4.24 0.17 0 3.74 1.41 TP53 72.19 36.12 56.24 11.48 50.53 32.94 0.47 29.68 46.21 KRAS 13.15 0.91 35.06 0.82 8.93 1.34 0.93 14.75 4.76 RB1 24.48 3.42 4 3.83 7.72 5.18 0.47 8.35 17.99