Real-World Burden of Adults with Major Depressive Disorder and Insomnia in the US (2019)

Journal of Affective Disorders 323 (2023) 698–706 Contents lists available at ScienceDirect Journal of Affective Disorders...

Journal of Affective Disorders 323 (2023) 698–706 Contents lists available at ScienceDirect Journal of Affective Disorders journal homepage: www.elsevier.com/locate/jad Research paper The real-world burden of adults with major depressive disorder with moderate or severe insomnia symptoms in the United States Kruti Joshi a, M. Janelle Cambron-Mellott b, *, Halley Costantino b, Alanna Pfau a, Manish K. Jha c, d a Janssen Scientific Affairs, LLC, Titusville, NJ, USA b Cerner Enviza, an Oracle Company, Kansas City, MO, USA c Icahn School of Medicine at Mount Sinai, New York, NY, USA d University of Texas Southwestern Medical Center, Dallas, TX, USA A R T I C L E I N F O A B S T R A C T Keywords: Background: Although insomnia is a common core symptom of major depressive disorder (MDD), the burden of Insomnia moderate-to-severe insomnia symptoms in patients with MDD is not well-understood. This study quantified the Depression clinical, patient-centric, and economic burden of adults with MDD with moderate-to-severe insomnia symptoms Major depressive disorder with insomnia (MDDIS) compared to adults with MDD with no-to-mild insomnia symptoms (other-MDD) and adults without symptoms Patient-centric burden MDD. Economic burden Methods: Data from 2019 US National Health and Wellness Survey identified adults self-reporting physician- Clinical burden diagnosed depression, stratified by insomnia status (MDDIS: Insomnia Severity Index [ISI] score ≥15; other- MDD: ISI score