Which of the following medications, used to treat dyslipidemia, primarily acts by inhibiting the absorption of cholesterol in the small intestine?
Understand the Problem
The question is asking to identify which medication, among the options provided, functions mainly by preventing cholesterol absorption in the small intestine. This is a pharmacology question focused on the mechanism of action of different lipid-lowering drugs.
Answer
Ezetimibe
Ezetimibe primarily inhibits cholesterol absorption in the small intestine.
Answer for screen readers
Ezetimibe primarily inhibits cholesterol absorption in the small intestine.
More Information
Ezetimibe inhibits the absorption of cholesterol in the small intestine by blocking thetransport protein Niemann Pick C1 Like 1 (NPC1L1).
Tips
A common mistake is confusing cholesterol absorption inhibitors with other classes of drugs that lower cholesterol, such as statins, which work by a different mechanism (HMG CoA reductase inhibition in the liver).
Sources
- Ezetimibe - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Inhibition of Intestinal Cholesterol Absorption by Ezetimibe in Humans - ahajournals.org
- Cholesterol absorption inhibitors – Knowledge and References - taylorandfrancis.com
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