Which factor has the shortest half-life among the clotting factors synthesized by the liver?

Understand the Problem

The question is asking for information regarding the half-lives of various clotting factors that are synthesized by the liver, specifically seeking to identify which one has the shortest half-life.

Answer

Factor VII

The clotting factor synthesized by the liver that has the shortest half-life is Factor VII.

Answer for screen readers

The clotting factor synthesized by the liver that has the shortest half-life is Factor VII.

More Information

Factor VII is known to have the shortest half-life among the hepatically synthethized clotting factors, generally ranging from about 2 to 6 hours. This short half-life makes it a sensitive indicator in liver function tests, such as the prothrombin time (PT), which is often one of the first tests to indicate liver impairment.

Tips

A common mistake is confusing the shortest half-life with the shortest activity period in the coagulation cascade. Make sure to differentiate between half-life and functional role.

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