What removes RNA primers?
Understand the Problem
The question is asking about the process or mechanism by which RNA primers are removed during DNA replication or repair. It is looking for the specific enzyme or process involved in this action.
Answer
RNase H and DNA polymerase I
The RNA primers are removed by RNase H and DNA polymerase I, which have different roles in different conditions and types of organisms. In E. coli, RNase H and DNA polymerase I are primarily responsible for this process.
Answer for screen readers
The RNA primers are removed by RNase H and DNA polymerase I, which have different roles in different conditions and types of organisms. In E. coli, RNase H and DNA polymerase I are primarily responsible for this process.
More Information
In E. coli and other prokaryotes, DNA polymerase I, which has 5' to 3' exonuclease activity, removes the RNA primer and replaces it with DNA. RNase H also helps by degrading the RNA in RNA-DNA hybrids. In eukaryotes, other enzymes such as FEN1 and RNase H2 are also involved in the removal process.
Sources
- The web page with info on - NCBI Bookshelf - ncbi.nlm.nih.gov
- How RNA primer on leading strand is removed during DNA replication - Biology Stack Exchange - biology.stackexchange.com
